Search Results

You are looking at 1 - 3 of 3 items for :

  • Abstract: Bone x
  • Abstract: Mineral x
  • Abstract: Calcium x
  • Abstract: Hypoparathyroidism x
  • Abstract: Skeleton x
  • Hormones and Cancer x
Clear All Modify Search
Anna Gorbacheva Endocrinology Research Center, Moscow, Russian Federation

Search for other papers by Anna Gorbacheva in
Google Scholar
PubMed
Close
,
Anna Eremkina Endocrinology Research Center, Moscow, Russian Federation

Search for other papers by Anna Eremkina in
Google Scholar
PubMed
Close
,
Daria Goliusova Endocrinology Research Center, Moscow, Russian Federation

Search for other papers by Daria Goliusova in
Google Scholar
PubMed
Close
,
Julia Krupinova Endocrinology Research Center, Moscow, Russian Federation

Search for other papers by Julia Krupinova in
Google Scholar
PubMed
Close
, and
Natalia Mokrysheva Endocrinology Research Center, Moscow, Russian Federation

Search for other papers by Natalia Mokrysheva in
Google Scholar
PubMed
Close

Multiple endocrine neoplasia type 1 (MEN1) is the most common cause of hereditary primary hyperparathyroidism (PHPT). Bone disorders are considered one of the key symptoms in PHPT present with the significant reduction in bone mineral density and low-energy fractures. Previously, these bone disorders were believed to be caused solely by the increase in the level of parathyroid hormone and its subsequent effect on bone resorption. The current paradigm, however, states that the mutations in the menin gene, which cause the development of MEN1, can also affect the metabolism of the cells of the osteoid lineage. This review analyzes both the proven and the potential intracellular mechanisms through which menin can affect bone metabolism.

Open access
Matteo Scopel Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

Search for other papers by Matteo Scopel in
Google Scholar
PubMed
Close
,
Eugenio De Carlo Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

Search for other papers by Eugenio De Carlo in
Google Scholar
PubMed
Close
,
Francesca Bergamo Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Search for other papers by Francesca Bergamo in
Google Scholar
PubMed
Close
,
Sabina Murgioni Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Search for other papers by Sabina Murgioni in
Google Scholar
PubMed
Close
,
Riccardo Carandina Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy

Search for other papers by Riccardo Carandina in
Google Scholar
PubMed
Close
,
Anna Rita Cervino Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

Search for other papers by Anna Rita Cervino in
Google Scholar
PubMed
Close
,
Marta Burei Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

Search for other papers by Marta Burei in
Google Scholar
PubMed
Close
,
Federica Vianello Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

Search for other papers by Federica Vianello in
Google Scholar
PubMed
Close
,
Vittorina Zagonel Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Search for other papers by Vittorina Zagonel in
Google Scholar
PubMed
Close
,
Matteo Fassan Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

Search for other papers by Matteo Fassan in
Google Scholar
PubMed
Close
, and
Roberto Vettor Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

Search for other papers by Roberto Vettor in
Google Scholar
PubMed
Close

We considered 351 patients affected by neuroendocrine tumors (NETs), followed at the University Hospital of Padua and at the Veneto Oncological Institute. Of these, 72 (20.5%) suffered from bone metastases. The sample was divided according to the timing of presentation of bone metastases into synchronous (within 6 months of diagnosis of primary tumor) and metachronous (after 6 months). We collected data on the type and grading of the primary tumor and on the features of bone metastases. Our analysis shows that the group of synchronous metastases generally presents primary tumors with a higher degree of malignancy rather than the ones of the metachronous group. This is supported by the finding of a Ki-67 level in GEP-NETs, at the diagnosis of bone metastases, significantly higher in the synchronous group. Moreover, in low-grade NETs, chromogranin A values are higher in the patients with synchronous metastases, indicating a more burden of disease. The parameters of phospho-calcium metabolism are within the normal range, and we do not find significant differences between the groups. Serious bone complications are not frequent and are not correlated with the site of origin of the primary tumor. From the analysis of the survival curves of the total sample, a cumulative survival rate of 33% at 10 years emerges. The average survival is 80 months, higher than what is reported in the literature, while the median is 84 months. In our observation period, synchronous patients tend to have a worse prognosis than metachronous ones with 52-months survival rates of 58 and 86%.

Open access
Jiaxin Luo Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Jiaxin Luo in
Google Scholar
PubMed
Close
,
Weili Yin Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Weili Yin in
Google Scholar
PubMed
Close
,
Qiuxia Lin The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Qiuxia Lin in
Google Scholar
PubMed
Close
,
Juqing Wu Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Juqing Wu in
Google Scholar
PubMed
Close
,
Pan Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Pan Chen in
Google Scholar
PubMed
Close
,
Yuanna Ling Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Yuanna Ling in
Google Scholar
PubMed
Close
,
Jing Wang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Jing Wang in
Google Scholar
PubMed
Close
,
Zhen Li Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Zhen Li in
Google Scholar
PubMed
Close
,
Liqin Pan Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Liqin Pan in
Google Scholar
PubMed
Close
,
Yanying Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Yanying Chen in
Google Scholar
PubMed
Close
,
Wei Ouyang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Wei Ouyang in
Google Scholar
PubMed
Close
, and
Huijuan Feng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

Search for other papers by Huijuan Feng in
Google Scholar
PubMed
Close

To evaluate the locoregional progression-free survival (LPFS) of bone metastatic lesions from differentiated thyroid cancer (DTC) after radioiodine therapy (RAIT) and to define its influencing factors, we performed a retrospective cohort analysis of 89 patients with bone metastases from DTC who received RAIT in our department over a 17-year period. The median follow-up time was calculated using the reverse Kaplan–Meier method. The log-rank test and a multivariate Cox proportional hazards regression model were performed in the analysis of prognostic indicators for LPFS. In this research, the median follow-up time for all patients was 47 (95% CI, 35.752–58.248) months, and that for patients with no progression was 42 months. The longest follow-up time was 109 months. The median LPFS time was 58 (95% CI, 32.602–83.398) months, and the 3- and 5-year LPFS probabilities were 57.8 and 45.1%, respectively. Multivariate analysis revealed bone structural changes as an independent risk factor for LPFS (P= 0.004; hazard ratio, 49.216; 95% CI, 3.558–680.704). Furthermore, the non–total-lesion uptake subgroup presented a worse LPFS than the total-lesion uptake subgroup in patients with structural bone lesions (P = 0.027). RAIT can improve the LPFS of radioiodine-avid bone metastases from DTC, especially those without bone structural changes.

Open access