/kg/day). Outcomes were: (1) cortisol excretion rate (µg/kg/day), (2) the sum of all glucocorticoid metabolites or corticosteroid excretion rate (µg/kg/day), and (3) the ratio of 11-hydroxy (11-OH)/11-oxoandrostenedione (11-OXO) metabolites, as an estimate of 11B
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Britt J van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F Hartmann, Johannes B van Goudoever, Stefan A Wudy, Joost Rotteveel, and Martijn J J Finken
Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen, and Geoffrey L Hammond
Introduction Corticosteroid-binding globulin (CBG) transports steroids in the blood and regulates their access to tissues and cells ( 1 , 2 ). Crystal structure analyses show that CBG contains a single hydrophobic steroid-binding site ( 3
Gavin P Vinson and Caroline H Brennan
(the therapeutic corticosteroid of choice at the time) was soon applied in the management of meperidine and morphine withdrawal symptoms in men (5) , apparently with beneficial effects, while Lovell associated alcoholism and drug addiction with
Trevor Lewis, Eva Zeisig, and Jamie E Gaida
and associated metabolic conditions, such as insulin resistance ( 5 ), diabetes ( 6 ), hypercholesterolaemia ( 7 ), statins ( 8 ), abdominal fat ( 9 ), the sympathetic nervous system ( 10 , 11 ), and corticosteroid use ( 12 ). Glucocorticoids are a
Muriel Houang, Thao Nguyen-Khoa, Thibaut Eguether, Bettina Ribault, Séverine Brabant, Michel Polak, Irène Netchine, and Antonin Lamazière
discriminant test, we questioned the mother regarding her medication. The mother happened to be on nasal spray corticosteroids (triamcinolone) throughout the pregnancy and during the neonatal period while she was breastfeeding. This significantly lowered all
Kamran Iqbal, Kate Halsby, Robert D Murray, Paul V Carroll, and Robert Petermann
information is well recorded and accurate ( 13 , 14 ). Study population The population of interest comprised patients with treated AI defined as an AI-specific Read code and at least one Multilex code for the corticosteroids of interest (i.e. IR HC
Stephanie E Baldeweg, Mark Vanderpump, Will Drake, Narendra Reddy, Andrew Markey, Gordon T Plant, Michael Powell, Saurabh Sinha, John Wass, and the Society for Endocrinology Clinical Committee
emergencies. Prompt resuscitation and corticosteroid replacement may be lifesaving. MRI scan is the investigation of choice. Urgent discussion with the regional neurosurgical/endocrine team is essential. Surgical intervention should be considered in
Marcus Quinkler, Bertil Ekman, Claudio Marelli, Sharif Uddin, Pierre Zelissen, Robert D Murray, and on behalf of the EU-AIR Investigators
development of corticosteroid side effects between patients ( 7 ). Interestingly, when the endogenous glucocorticoid, cortisol (hydrocortisone), is compared with prednisolone at the isolated human glucocorticoid receptor (GR), the transactivation activity of
Greta B Raglan, Louis A Schmidt, and Jay Schulkin
as a possible intervention for mental illness including depression. Although further study is necessary, it appears that corticosteroid synthesis inhibitors (CSIs) may show some efficacy in treating individuals with intractable depression ( 23
Martijn J J Finken, Aleid J G Wirix, Ines A von Rosenstiel-Jadoul, Bibian van der Voorn, Mai J M Chinapaw, Michaela F Hartmann, Joana E Kist-van Holthe, Stefan A Wudy, and Joost Rotteveel
, raised blood pressure, insulin resistance, and dyslipidemia ( 7 , 10 ). There is controversy as to whether increased HPA axis activity is a cause or a consequence of childhood obesity. It has been demonstrated that the rise in serum corticosteroids