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Ailsa Maria Main, Maria Rossing, Line Borgwardt, Birgitte Grønkær Toft, Åse Krogh Rasmussen, and Ulla Feldt-Rasmussen

first screening. The family members with PPGLs displayed markers of poor prognosis including metastatic disease and markers included in the PASS (Supplementary material) and the variant might be associated with a high risk of tumour development in adults

Open access

Leanne Hodson and Fredrik Karpe

tissue) and how dysregulation of these processes may play a role in the development of insulin resistance and/or IHTAG accumulation in humans. Although there are new therapies in the pipeline for the treatment of NAFLD/insulin resistance, there are many

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Corina Verónica Sasso, Flavia Eliana Santiano, Fiorella Campo Verde Arboccó, Leila Ester Zyla, Silvana Noemí Semino, Martin Eduardo Guerrero-Gimenez, Virginia Pistone Creydt, Constanza Matilde López Fontana, and Rubén Walter Carón

40%, respectively, higher in men than in women ( 1 ). Since the Women’s Health Initiative in 1991 ( 2 ), and several epidemiological studies, the ovarian steroids were considered protectors against the development of CRC. Different studies in animal

Open access

T L C Wolters, C D C C van der Heijden, N van Leeuwen, B T P Hijmans-Kersten, M G Netea, J W A Smit, D H J Thijssen, A R M M Hermus, N P Riksen, and R T Netea-Maier

, which promotes a pro-inflammatory and pro-atherogenic environment. Although the importance of innate immune cells in the development and progression of atherosclerosis is widely accepted, the unresolving character of the low-grade inflammation that

Open access

A V Dreval, I V Trigolosova, I V Misnikova, Y A Kovalyova, R S Tishenina, I A Barsukov, A V Vinogradova, and B H R Wolffenbuttel

ECMDs to be higher than that of overt diabetes (2, 5, 6, 7) , not all studies report the same prevalence (3, 8) . The development of ECMDs and/or progression to diabetes in patients with acromegaly may depend on several factors, such as age and gender

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Catarina I Gonçalves, José M Aragüés, Margarida Bastos, Luísa Barros, Nuno Vicente, Davide Carvalho, and Manuel C Lemos

Introduction Congenital hypogonadotropic hypogonadism (CHH) is characterised by partial or complete lack of pubertal development, secondary to deficient gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion ( 1 ). Diagnosis is

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Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani, and Kristina Schaedlich

influence during early development (i.e. preconceptional up to 1000 days of postnatal life) can program the unborn/newborn for metabolic dysfunctions later in life. Apart from environmental factors maternal diseases such as overweight or excessive weight

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Maria Stelmachowska-Banaś and Izabella Czajka-Oraniec

should not delay hormonal workup and treatment initiation, which mostly depend on clinical presentation and demonstration of hypopituitarism ( 6 , 50 ). On the other hand, pituitary MRI abnormalities can precede the development of pituitary deficiency

Open access

Kristin Ottarsdottir, Margareta Hellgren, David Bock, Anna G Nilsson, and Bledar Daka

-sectional studies have found an inverse association between levels of SHBG and insulin resistance in men ( 9 , 10 ) and women ( 11 , 12 ). Only few studies have investigated whether levels of SHBG can predict the development of insulin resistance, and there are no

Open access

Iben Katinka Greiber, Casper P Hagen, Alexander Siegfried Busch, Mikkel Grunnet Mieritz, Lise Aksglæde, Katharina Main, Kristian Almstrup, and Anders Juul

assess the effect of genetic variation of AMH signaling ( AMH rs10407022 T>G and AMHR2 rs11170547 C>T) on circulating hormone levels in boys and girls during pubertal development. Our findings support recent GWAS results in young adults and expand