Search Results

You are looking at 81 - 90 of 608 items for :

  • development x
  • All content x
Clear All
Open access

Katherine Van Loon, Li Zhang, Jennifer Keiser, Cendy Carrasco, Katherine Glass, Maria-Teresa Ramirez, Sarah Bobiak, Eric K Nakakura, Alan P Venook, Manisha H Shah, and Emily K Bergsland

symptoms, and the development of any SRE were abstracted. Bone metastases were considered synchronous if they were identified within 3 months of diagnosis of the primary tumor. If bone metastases were identified beyond 3 months after diagnosis, they were

Open access

Ailsa Maria Main, Maria Rossing, Line Borgwardt, Birgitte Grønkær Toft, Åse Krogh Rasmussen, and Ulla Feldt-Rasmussen

first screening. The family members with PPGLs displayed markers of poor prognosis including metastatic disease and markers included in the PASS (Supplementary material) and the variant might be associated with a high risk of tumour development in adults

Open access

Elizabeth Yan Zhang and Bao-Ting Zhu

estrogens, such as those observed during human pregnancy, are immunosuppressive (1) . For example, 17β-estradiol (E 2 ) and estriol (E 3 ) at suitable doses can inhibit the development of experimental autoimmune encephalomyelitis (EAE) (2, 3, 4) and

Open access

Urszula Smyczyńska, Joanna Smyczyńska, Maciej Hilczer, Renata Stawerska, Ryszard Tadeusiewicz, and Andrzej Lewiński

defined by Ranke as a new paradigm for GH treatment in 21st century ( 3 ). Moreover, the use of growth prediction models has been proposed as a personalized approach to GH treatment in clinical practice ( 4 ). Development of such models should allow to

Open access

Corina Verónica Sasso, Flavia Eliana Santiano, Fiorella Campo Verde Arboccó, Leila Ester Zyla, Silvana Noemí Semino, Martin Eduardo Guerrero-Gimenez, Virginia Pistone Creydt, Constanza Matilde López Fontana, and Rubén Walter Carón

40%, respectively, higher in men than in women ( 1 ). Since the Women’s Health Initiative in 1991 ( 2 ), and several epidemiological studies, the ovarian steroids were considered protectors against the development of CRC. Different studies in animal

Open access

Leanne Hodson and Fredrik Karpe

tissue) and how dysregulation of these processes may play a role in the development of insulin resistance and/or IHTAG accumulation in humans. Although there are new therapies in the pipeline for the treatment of NAFLD/insulin resistance, there are many

Open access

T L C Wolters, C D C C van der Heijden, N van Leeuwen, B T P Hijmans-Kersten, M G Netea, J W A Smit, D H J Thijssen, A R M M Hermus, N P Riksen, and R T Netea-Maier

, which promotes a pro-inflammatory and pro-atherogenic environment. Although the importance of innate immune cells in the development and progression of atherosclerosis is widely accepted, the unresolving character of the low-grade inflammation that

Open access

A V Dreval, I V Trigolosova, I V Misnikova, Y A Kovalyova, R S Tishenina, I A Barsukov, A V Vinogradova, and B H R Wolffenbuttel

ECMDs to be higher than that of overt diabetes (2, 5, 6, 7) , not all studies report the same prevalence (3, 8) . The development of ECMDs and/or progression to diabetes in patients with acromegaly may depend on several factors, such as age and gender

Open access

Catarina I Gonçalves, José M Aragüés, Margarida Bastos, Luísa Barros, Nuno Vicente, Davide Carvalho, and Manuel C Lemos

Introduction Congenital hypogonadotropic hypogonadism (CHH) is characterised by partial or complete lack of pubertal development, secondary to deficient gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion ( 1 ). Diagnosis is

Open access

Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani, and Kristina Schaedlich

influence during early development (i.e. preconceptional up to 1000 days of postnatal life) can program the unborn/newborn for metabolic dysfunctions later in life. Apart from environmental factors maternal diseases such as overweight or excessive weight