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Rajae Talbi and Victor M Navarro

neurons in the control of reproduction and metabolism. On one hand, Kiss1 ARC neurons are direct targets of central and peripheral metabolic cues, which form an essential regulatory element of the HPG axis from early stages of development. On the other

Open access

Richard P Steeds, Vandana Sagar, Shishir Shetty, Tessa Oelofse, Harjot Singh, Raheel Ahmad, Elizabeth Bradley, Rachel Moore, Suzanne Vickrage, Stacey Smith, Ivan Yim, Yasir S Elhassan, Hema Venkataraman, John Ayuk, Stephen Rooney, and Tahir Shah

centralising care to a limited number of centres able to invest in the required service development and having the appropriate infrastructure for multidisciplinary care may be the best way to improve outcomes for CHD patients. Pathophysiology of CHD In

Open access

Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, and Manfredi Rizzo

development of gestational diabetes (GDM) cases ( 1 ). Epidemiological evidence has consistently shown that among mothers with prior history of GDM, 30–84% of them had GDM recurrence in subsequent pregnancies ( 2 ), 20–40% developed metabolic syndrome (MetS

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Elizabeth Micks, Greta B Raglan, and Jay Schulkin

these issues (6) . Reducing unmet need for family planning represents one of the most effective strategies for improving maternal health (7) , and progestogens remain one of the most promising avenues for contraceptive research and development. However

Open access

Legh Wilkinson, Nicolette J D Verhoog, and Ann Louw

signalling, often resulting in various peripheral effects, one of which is the tissue-specific reductions in the glucocorticoid receptor α (GRα) functional pool. This reduction in the GRα functional pool may ultimately drive the development of acquired GC

Open access

Yiqiong Ma, Zhaowei Chen, Yu Tao, Jili Zhu, Hongxia Yang, Wei Liang, and Guohua Ding

progression of DN ( 13 ). Our previous studies confirmed that high levels of glucose cause mitochondrial ROS production and increases the podocyte apoptosis rate ( 14 , 15 ). However, whether mitochondrial dynamics contribute to the development and

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Doron Weinstein, Rive Sarfstein, Zvi Laron, and Haim Werner

are effectively used in clinical settings (2, 4) . The insulin-like growth factor (IGF) system has an important role in the normal growth and development of the prostate gland (5) . In addition to its physiological role, epidemiological, clinical

Open access

Ram P Narayanan, Bo Fu, Adrian H Heald, Kirk W Siddals, Robert L Oliver, Julie E Hudson, Antony Payton, Simon G Anderson, Anne White, William E R Ollier, and J Martin Gibson

development and progression of diabetic kidney disease is influenced by a number of biological factors. Among these, the insulin-like growth factor (IGF) family of proteins have been repeatedly implicated in the development of nephropathy and other

Open access

Jülide Durmuşoğlu, Henri J L M Timmers, Pepijn van Houten, Hans F Langenhuijsen, Ad R M M Hermus, and Annenienke C van de Ven

number of patients included. ACC patients were divided in two groups; patients with the development of postoperative VTE and patients without the development of postoperative VTE. Categorical data were compared with use of Fisher’s exact test. Continuous

Open access

Qi Che, Xirong Xiao, Jun Xu, Miao Liu, Yongning Lu, Suying Liu, and Xi Dong

-rabbit or anti-mouse secondary antibody (Cell Signaling Technology). The labeled proteins were detected by enhanced chemiluminescense. β-actin was used as an internal control. Development of an orthotopic endometrial carcinoma model in nude mice