neurons in the control of reproduction and metabolism. On one hand, Kiss1 ARC neurons are direct targets of central and peripheral metabolic cues, which form an essential regulatory element of the HPG axis from early stages of development. On the other
Richard P Steeds, Vandana Sagar, Shishir Shetty, Tessa Oelofse, Harjot Singh, Raheel Ahmad, Elizabeth Bradley, Rachel Moore, Suzanne Vickrage, Stacey Smith, Ivan Yim, Yasir S Elhassan, Hema Venkataraman, John Ayuk, Stephen Rooney, and Tahir Shah
centralising care to a limited number of centres able to invest in the required service development and having the appropriate infrastructure for multidisciplinary care may be the best way to improve outcomes for CHD patients. Pathophysiology of CHD In
Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, and Manfredi Rizzo
development of gestational diabetes (GDM) cases ( 1 ). Epidemiological evidence has consistently shown that among mothers with prior history of GDM, 30–84% of them had GDM recurrence in subsequent pregnancies ( 2 ), 20–40% developed metabolic syndrome (MetS
Elizabeth Micks, Greta B Raglan, and Jay Schulkin
these issues (6) . Reducing unmet need for family planning represents one of the most effective strategies for improving maternal health (7) , and progestogens remain one of the most promising avenues for contraceptive research and development. However
Legh Wilkinson, Nicolette J D Verhoog, and Ann Louw
signalling, often resulting in various peripheral effects, one of which is the tissue-specific reductions in the glucocorticoid receptor α (GRα) functional pool. This reduction in the GRα functional pool may ultimately drive the development of acquired GC
Yiqiong Ma, Zhaowei Chen, Yu Tao, Jili Zhu, Hongxia Yang, Wei Liang, and Guohua Ding
progression of DN ( 13 ). Our previous studies confirmed that high levels of glucose cause mitochondrial ROS production and increases the podocyte apoptosis rate ( 14 , 15 ). However, whether mitochondrial dynamics contribute to the development and
Doron Weinstein, Rive Sarfstein, Zvi Laron, and Haim Werner
are effectively used in clinical settings (2, 4) . The insulin-like growth factor (IGF) system has an important role in the normal growth and development of the prostate gland (5) . In addition to its physiological role, epidemiological, clinical
Ram P Narayanan, Bo Fu, Adrian H Heald, Kirk W Siddals, Robert L Oliver, Julie E Hudson, Antony Payton, Simon G Anderson, Anne White, William E R Ollier, and J Martin Gibson
development and progression of diabetic kidney disease is influenced by a number of biological factors. Among these, the insulin-like growth factor (IGF) family of proteins have been repeatedly implicated in the development of nephropathy and other
Jülide Durmuşoğlu, Henri J L M Timmers, Pepijn van Houten, Hans F Langenhuijsen, Ad R M M Hermus, and Annenienke C van de Ven
number of patients included. ACC patients were divided in two groups; patients with the development of postoperative VTE and patients without the development of postoperative VTE. Categorical data were compared with use of Fisher’s exact test. Continuous
Qi Che, Xirong Xiao, Jun Xu, Miao Liu, Yongning Lu, Suying Liu, and Xi Dong
-rabbit or anti-mouse secondary antibody (Cell Signaling Technology). The labeled proteins were detected by enhanced chemiluminescense. β-actin was used as an internal control. Development of an orthotopic endometrial carcinoma model in nude mice
