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David Koeckerling, Jeremy W Tomlinson, and Jeremy F Cobbold

neither NAFL nor NASH, but only the presence of fibrosis directly influences clinically relevant outcomes. Do NAFL and NASH differ in their fibrogenic potential? In a systematic review of 221 patients with biopsy-proven NASH, 37.6% of patients demonstrated

Open access

Joana Simões-Pereira, Daniel Macedo, and Maria João Bugalho

analysis. Finally, clinical records were reviewed to evaluate the demographic characteristics, clinical presentation, diagnostic approach, therapeutic modalities and clinical outcome. The results presented herein resulted from a retrospective study based

Open access

M L M Barreto-Chaves, N Senger, M R Fevereiro, A C Parletta, and A P C Takano

process, in order to identify possible novel therapeutic targets, is clear. In this context, this review will describe the basic aspects of TH action, focusing on the molecular and cellular mechanisms associated with cardiac hypertrophy, and the

Open access

K Amrein, A Papinutti, E Mathew, G Vila, and D Parekh

clinical practice if the on-going trials show benefit. Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review. Funding K A received speaker

Open access

Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou, and David Møbjerg Kristensen

the bile and later intestines ( 7 ). Several experimental and epidemiological studies have in recent years investigated a possible link between prenatal mild analgesics exposure and effects on the male reproductive system (reviewed in 2 ). Studies

Open access

Adriano N Cury, Verônica T Meira, Osmar Monte, Marília Marone, Nilza M Scalissi, Cristiane Kochi, Luís E P Calliari, and Carlos A Longui

a fixed dose for all patients, aiming to induce remission of the disease and achieve hypothyroidism or euthyroidism (12) . Patients and methods We reviewed the medical records of 65 patients who were followed between 1985 and 2005 with

Open access

E T Aristizabal Prada and C J Auernhammer

. This review is focused on novel putative targeted therapies for well-differentiated NETs with G1/G2 grading of the GEP system ( 19 , 20 ). We review current preclinical and early clinical data on several putative novel targets and future challenges for

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Xi Wang and Qi Yu

Hospital as part of a long-standing MAS natural history study. The study was approved by the Institutional Review Board of Peking Union Medical College Hospital (Number S-K445). Informed consent was obtained in accordance with the institutional guidelines

Open access

Legh Wilkinson, Nicolette J D Verhoog, and Ann Louw

development of further GC insensitivity. This review begins by briefly describing the types of GC resistance and then discusses reductions in the GRα pool in various pathological and psychological conditions, in terms of acquired GC resistance. Primary focus

Open access

Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha, and Adelino Leite-Moreira

, an understanding of the role of THs in the cardiovascular system is imperative ( 1 ). The main goal of this manuscript is to review the central pathophysiological and clinical links between altered thyroid function and cardiovascular diseases