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Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

transcripts were analysed with DAVID Bioinformatic Resources ( 23 ). Cluster analysis of genes involved in signalling, sterol and lipid metabolism and cell turnover was carried out with Miru software ( 24 ). Genes of interest that are discussed are listed in

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Yao Chen and Shu-ying Fang

Introduction Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder of reproductive aged women, which usually causes reproduction and metabolism failure ( 1 , 2 ). It often presents as hyperandrogenism, hyperinsulinemia

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Stan Ursem, Vito Francic, Martin Keppel, Verena Schwetz, Christian Trummer, Marlene Pandis, Felix Aberer, Martin R Grübler, Nicolas D Verheyen, Winfried März, Andreas Tomaschitz, Stefan Pilz, Barbara Obermayer-Pietsch, and Annemieke C Heijboer

, we investigated the relationship between bone resorption and formation markers, markers of lipid metabolism and parameters of mineral metabolism and oxidative stress with n-oxPTH and tPTH. Subjects and methods Study design and participants

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A V Dreval, I V Trigolosova, I V Misnikova, Y A Kovalyova, R S Tishenina, I A Barsukov, A V Vinogradova, and B H R Wolffenbuttel

Introduction Disturbances of glucose metabolism are frequently observed in patients with acromegaly. In one of the first papers to be published on this topic, abnormal glucose tolerance was found in over 60% of patients with acromegaly (1) . The

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Lijuan Yuan, Xihui Chen, Ziyu Liu, Dan Wu, Jianguo Lu, Guoqiang Bao, Sijia Zhang, Lifeng Wang, and Yuanming Wu

prostaglandin metabolism in women of reproductive age and in women in menopause. The altered sex hormone levels might contribute to the late-onset symptoms in females ( 45 ). The deregulation of menstrual cycle might be a new clinical feature for women SLCO2A1

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Tingting Shu, Zhigang Lv, Yuchun Xie, Junming Tang, and Xuhua Mao

Introduction Hepcidin is synthesized and secreted primarily in the liver and is a key regulator in iron metabolism ( 1 , 2 ). In 2008, Kulaksiz et al. first reported that hepcidin was expressed in human and rat islet tissues and only

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Julie Smith, Jan Fahrenkrug, Henrik L Jørgensen, Christina Christoffersen, and Jens P Goetze

-A and NPR-C receptor activity in adipose tissue has also been suggested to play a role in the fat metabolism, as the NPR-C adjusts the locally available natriuretic peptide concentration by degradation (4) . It is well established that white

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A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, and Timothy J Cole

. Recently published evidence have shown that HSD1L is unlikely to be involved in interconversion of cortisol and cortisone, nor metabolism of 11-keto or 11-hydroxy-testosterone ( 17 ), but given the high levels of sequence homology and tissue localisation, a

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Selina Mäkinen, Yen H Nguyen, Paulina Skrobuk, and Heikki A Koistinen

 h ( Fig. 2C ). Glucose metabolism Glucose uptake To analyse if the observed changes in signalling events are reflected at glucose metabolism, human primary myotubes were pre-exposed to palmitate, oleate or their combination for 12 h

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R Solomon-Zemler, L Basel-Vanagaite, D Steier, S Yakar, E Mel, M Phillip, L Bazak, D Bercovich, H Werner, and L de Vries

metabolism. In vitro studies revealed that fibroblasts derived from the patient showed reduced proliferation and impaired IGF1R activation. Our data underline the key role of the IGF1R in the regulation of both growth and metabolic processes. Patients