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Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka, and Rod T Mitchell

involved in maintenance of the germ-stem cell niche and highlighted their impacts on fertility when these pathways are disrupted (reviewed in ( 2 , 3 )). In humans, cancer and its treatment are a recognised cause of subsequent infertility. This may be as

Open access

E M Winter, A Ireland, N C Butterfield, M Haffner-Luntzer, M-N Horcajada, A G Veldhuis-Vlug, L Oei, G Colaianni, and N Bonnet

this, the World Health Organization (WHO) recommends an extra dietary calcium intake of 200 mg/day for pregnant women compared to non-pregnant women ( 6 , 7 ). Here, we review the current knowledge of how the female skeleton physiologically adapts to

Open access

Nicola Tufton, Lucy Shapiro, Anju Sahdev, Ajith V Kumar, Lee Martin, William M Drake, Scott A Akker, and Helen L Storr

regular surveillance imaging, there is no clear consensus regarding the optimal modality or frequency. The situation is even less clear in paediatric SDHB carriers due to the paucity of robust data, highlighted in a recent review ( 9 ). Since the

Open access

Jaafar Jaafar, Eugenio Fernandez, Heba Alwan, and Jacques Philippe

care givers and specialists. Other than endocrinologists, primary care doctors and other specialists, such as pneumologists, gastroenterologists, dermatologists, hematologists and neurologists, are concerned by these irAEs. This review addresses the

Open access

Anna Olsson-Brown, Rosemary Lord, Joseph Sacco, Jonathan Wagg, Mark Coles, and Munir Pirmohamed

of autoantibodies with biochemical change. Furthermore, we examined whether ypothyroidism was indeed the predominant manifestation of ICI-induced thyroid toxicity. Materials and methods A retrospective review of case notes of patients treated

Open access

Aleksandra Gilis-Januszewska, Łukasz Kluczyński, and Alicja Hubalewska-Dydejczyk

per 100,000 in the USA ( 5 ). The recent systematic review by Nguyen et al. concluded that the pooled annual incidence rate of TBI is 349 per 100,000 person-years. Mild, moderate, and severe TBI pooled annual incidence were 224, 23, and 13 per 100

Open access

Ruth Therese Casey, Deborah Saunders, Benjamin George Challis, Deborah Pitfield, Heok Cheow, Ashley Shaw, and Helen Lisa Simpson

magnitude of exposure. Methods We performed a retrospective review of medical records of 54 patients attending our institution with a confirmed clinical or genetic diagnosis of MEN1 between the years 2007 and 2015. We obtained clinical and

Open access

Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, and John Nestler

been evaluated in randomized controlled trials (RCTs). A protocol critically reviewing the existing literature has been published within the Cochrane Reviews ( 36 ). The present meta-analysis would identify RCTs of supplementation with MI alone or

Open access

André Marques-Pinto and Davide Carvalho

gamete production through to intrauterine development of the offspring – is believed to be particularly susceptible to endocrine disruption, triggering morphological and functional abnormalities (25, 26, 27) . The main purpose of this paper is to review

Open access

Aldo Bonaventura, Fabrizio Montecucco, and Franco Dallegri

and compliance with achieving good glycemic control that minimizes the risk of diabetic complications, with a consequent increase in cardiovascular (CV) and neurological morbidities. In this review, based on the material searched for and obtained via