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Peter Wolf, Yvonne Winhofer, Martin Krššák, and Michael Krebs

in various endocrine diseases also impact the cardiac morphology and function. We and others have demonstrated the importance of a well-balanced hormonal and metabolic homeostasis to maintain myocardial energy metabolism so that heart function can

Open access

E N Dudinskaya, O N Tkacheva, M V Shestakova, N V Brailova, I D Strazhesko, D U Akasheva, O Y Isaykina, N V Sharashkina, D A Kashtanova, and S A Boytsov

(3) . Experimental data show that glucose metabolism disorders induce vascular changes. For instance, Facchini et al . (4) showed that hyperinsulinaemia regardless of hyperglycaemia may promote oxidative stress and thereby accelerate vascular

Open access

Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp, and Evgeni Levin

(fasting) blood sample was taken first. Then, subjects ingested a liquid meal containing 616 kcal/2.6 MJ, containing 61% fat, 33% carbohydrate and protein 6% ( 11 ). Blood was sampled for postprandial metabolism at every 30 min for 4 h. These samples were

Open access

Amalie R Lanng, Lærke S Gasbjerg, Natasha C Bergmann, Sigrid Bergmann, Mads M Helsted, Matthew P Gillum, Bolette Hartmann, Jens J Holst, Tina Vilsbøll, and Filip K Knop

glucose metabolism ( 2 ). It is well known that acute alcohol ingestion increases the risk of hypoglycaemia; most likely due to inhibitory effects of alcohol on hepatic gluconeogenesis ( 3 ). In addition, it is well known that chronic alcohol consumption

Open access

Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller, and Henning Grønbæk

as obesity, sepsis, insulin resistance, diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD) ( 1 , 2 , 3 , 4 , 5 , 6 ). These diseases are also associated with changes in the lipid metabolism, accelerated lipolysis and

Open access

Emmely M de Vries, Hermina C van Beeren, Albert C W A van Wijk, Andries Kalsbeek, Johannes A Romijn, Eric Fliers, and Anita Boelen

regulation, fasting changes peripheral thyroid hormone (TH) metabolism, thereby contributing to the low serum TH concentrations ( 2 , 3 , 4 ), and also to low tissue TH concentrations ( 5 ). In the liver, TH can be metabolized via different pathways

Open access

Eva Novoa, Marcel Gärtner, and Christoph Henzen

aimed to assess the possible systemic effects of IT-Dex injections on the HPA axis and bone metabolism, particularly on osteoblast function, as highly sensitive cells to exogenous glucocorticoids, in a prospective cohort study of patients receiving IT

Open access

Huguette S Brink, Aart Jan van der Lely, and Joke van der Linden

( 12 , 13 ). Hence, there is need to predict and detect GD earlier in pregnancy in order to limit the exposure to impaired glucose metabolism. Investigating the role of adipokines associated with the pathophysiology of GD has gained interest ( 14 , 15

Open access

Tao Yuan, Lanping Jiang, Chen Chen, Xiaoyan Peng, Min Nie, Xuemei Li, Xiaoping Xing, Xuewang Li, and Limeng Chen

600968) of the distal convoluted tubule (DCT) ( 2 ). Recently ( 3 ), impaired glucose metabolism and insulin sensitivity were reported in GS patients, but insulin secretion function has not been studied in this population. Due to the lack of research in

Open access

Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

transcripts were analysed with DAVID Bioinformatic Resources ( 23 ). Cluster analysis of genes involved in signalling, sterol and lipid metabolism and cell turnover was carried out with Miru software ( 24 ). Genes of interest that are discussed are listed in