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Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant, and Agnès Linglart

). The resulting hypercortisolism causes considerable morbidity in childhood and adolescence, predominantly affecting growth and pubertal development ( 1 , 4 , 5 , 6 , 7 , 8 ). The diagnosis is often delayed by at least 2 years after the first

Open access

Yu Ah Hong, Kyung-Do Han, Jae-Seung Yun, Eun Sil Sil, Seung-Hyun Ko, and Sungjin Chung

-risk patients with type 2 DM who would benefit from intensive treatment and follow-up is very important to prevent or delay the development of ESRD. Advanced age, duration of diabetes, poor glycemic control, hypertension, dyslipidemia, obesity, ethnicity, and

Open access

Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka, and Rod T Mitchell

treatment on the testis or in supporting the restoration of fertility following treatment is poorly understood ( 5 ). In this review, we will describe the development and function of the key somatic cell populations in the testis and how they may be

Open access

Renea A Taylor, Jennifer Lo, Natasha Ascui, and Matthew J Watt

weeks No effects on tumour development, tumour differentiation, tumour grade, age of tumour palpation and age of death assessed after 36–40 weeks. Note, no difference in body mass. 24  TRAMP mice LFD (16% fat) vs HFD (40% fat) starting at 3 weeks

Open access

Lian Hollander-Cohen, Benjamin Böhm, Krist Hausken, and Berta Levavi-Sivan

hormone synthesis, and ovulation throughout the time-sensitive process of gonad maturation. Generally speaking, circulating FSH levels are higher during gonad development and maturation, and circulating LH levels rise during the final stages of maturation

Open access

Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Kaio Fernando Vitzel, Thiago Pantaleão, Vânia Maria Corrêa da Costa, and Maria Tereza Nunes

Introduction Iodine is essential for thyroxine (T 4 ) and triiodothyronine (T 3 ) synthesis, which are the only iodine-containing hormones in vertebrates and exert crucial effects on the regulation of development, metabolism and growth ( 1

Open access

Simonetta Piana, Eleonora Zanetti, Alessandra Bisagni, Alessia Ciarrocchi, Davide Giordano, Federica Torricelli, Teresa Rossi, and Moira Ragazzi

regulates many fundamental processes during development and homeostasis of a wide range of tissues. As a consequence, deregulation of this pathway has been linked to multiple human disorders, from congenital syndromes to cancer ( 1 , 2 , 3 ). NOTCH

Open access

K E Lines, R P Vas Nunes, M Frost, C J Yates, M Stevenson, and R V Thakker

diagnosed at a metastatic stage and not curable by surgery ( 5 , 6 , 7 , 8 ). In addition, over 40% of sporadic (non-familial) PNETs also show mutations in the MEN1 gene ( 8 , 9 ). Thus, MEN1 mutations are frequently associated with PNET development

Open access

Emma Jernberg, Anders Bergh, and Pernilla Wikström

, nilutamide and bicalutamide) reduces the risk of PC death by 10–30% compared to castration alone ( 8 ). Through the development of the 2nd-generation AR antagonists such as enzalutamide and apalutamide and the steroidogenesis inhibitor abiraterone acetate

Open access

W Liu, Y Wang, X Han, X Cai, Y Zhu, M Zhang, S Gong, J Li, and L Ji

reasonable to infer that the higher prevalence of DN in the present study was largely due to poor diabetes care in the past. We found that birth location was associated with the development of DN in the present study. This is an important sociodemographic