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Jennifer K Y Ko, Thomas F J King, Louise Williams, Sarah M Creighton, and Gerard S Conway

gonadectomy and in the absence of guidelines on the most appropriate HRT for this group of women, our clinic philosophy has been to offer choice and follow individual preference. Here, we reviewed our experience on HRT choices made by women with CAIS

Open access

Luminita Nicoleta Cima, Anca Colita, and Simona Fica

chronic graft vs host disease implies a risk of consequent gonadotoxicity ( 8 , 9 , 10 ). A review of the literature on gonadal toxicity of HSCT clearly stated that the risk of ovarian damage and POF is very high in HSCT recipients ( 11 ). Gonadal damage

Open access

Emma Jernberg, Anders Bergh, and Pernilla Wikström

activation by other factors, as extensively reviewed previously ( 6 , 7 ). Thus, the AR has for a long time been the main target in the treatment of advanced PC, and the combination of castration therapy with 1st-generation antiandrogens (flutamide

Open access

Ann-Kristin Picke, Graeme Campbell, Nicola Napoli, Lorenz C Hofbauer, and Martina Rauner

mechanisms, which may differently affect bone metabolism. In both cases, the underlying mechanisms of poor bone strength are not well understood. Considering that T2DM accounts for the majority of diabetes cases (>90%), this review will focus on summarizing

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Huguette S Brink, Aart Jan van der Lely, and Joke van der Linden

GD pathogenesis. Combining biomarkers and risk factors into a predictive model may add to early prediction of GD, evoke effective prevention strategies and may ultimately reduce complications associated with GD. The aim of this review is to ( 1

Open access

Carolina Inda, Natalia G Armando, Paula A dos Santos Claro, and Susana Silberstein

been implicated in CRHR functions, including ERK1/2 and p38 MAPKs, PKA, Akt, NFkB, GSK-3b/Wnt, RhoA as well as other important signaling molecules such as cAMP, calcium, IP3 and nitric oxide/cGMP ( 10 ). Here, we review the principal characteristics

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen, and on behalf of the Growth Hormone Research Society

, Denmark, on November 15–18, 2017 to review the current state of the field and address key issues regarding the definition of clinical endpoints for GH therapy and treatment of acromegaly, to critically evaluate current surrogate endpoints for GH therapy

Open access

Ping Li, Fei Cheng, and Lei Xiu

Cochrane Database of Systematic Reviews. The search strategies were (growth hormone or somatotropin or somatropin or somatotrophin or somatrophin or Pituitary Growth Hormone or Recombinant Growth Hormones) and (Turner syndrome or Ullrich-Turner Syndrome or

Open access

Yao Chen and Shu-ying Fang

steroid biosynthesis and action, gonadotropic secretion and action, folliculogenesis, weight and energy regulation and insulin action ( 13 ). In this review, we aimed to provide an overview of the main genetic polymorphisms that were found or

Open access

Rosalie Cabry, Philippe Merviel, Aicha Madkour, Elodie Lefranc, Florence Scheffler, Rachel Desailloud, Véronique Bach, and Moncef Benkhalifa

documented, only few studies have examined the direct impact of pesticides on fertility (and especially in female infertility) in IVF programmes. Hence, the objective of the present review was to assess the impact of the most frequently used pesticides on