. These symptoms are often paroxysmal and can be spontaneous or induced by a variety of events, such as strenuous physical exertion, delivery, trauma, anesthesia induction, and surgery ( 3 ). Although the mainstay strategy for treatment of
Hongyan Wang, Bin Wu, Zichuan Yao, Xianqing Zhu, Yunzhong Jiang, and Song Bai
Myrtille Fouché, Yves Bouffard, Mary-Charlotte Le Goff, Johanne Prothet, François Malavieille, Pierre Sagnard, Françoise Christin, Davy Hayi-Slayman, Arnaud Pasquer, Gilles Poncet, Thomas Walter, and Thomas Rimmelé
Octreotide was administered 12–48 h prior to surgery by intravenous continuous infusion at a dose of 40 µg/h or 80 µg/h if patient had prior CS, hepatic metastases or carcinoid heart disease. Octreotide was continued during the intraoperative and
Henri Honka, Jukka Koffert, Saila Kauhanen, Nobuyuki Kudomi, Saija Hurme, Andrea Mari, Andreas Lindqvist, Nils Wierup, Riitta Parkkola, Leif Groop, and Pirjo Nuutila
nutrients and hormones secreted from the gut and pancreas elicit a shift in hepatic glucose metabolism toward net uptake ( 3 ). However, little is known about hepatic blood flow and volume (HBV) responses to a mixed-meal after bariatric surgery. The
A Gizard, A Rothenbuhler, Z Pejin, G Finidori, C Glorion, B de Billy, A Linglart, and P Wicart
treatment has been associated with better outcomes ( 3 , 8 , 9 , 10 , 11 ). Orthopedic corrective surgery is indicated if there is marked leg bowing, with immediate functional consequences or long-term threats to the joints. Usually, the bone
Prachi Bansal, Anurag Lila, Manjunath Goroshi, Swati Jadhav, Nilesh Lomte, Kunal Thakkar, Atul Goel, Abhidha Shah, Shilpa Sankhe, Naina Goel, Neelam Jaguste, Tushar Bandgar, and Nalini Shah
mortality ( 2 ). Transsphenoidal surgery (TSS) of pituitary adenoma is the primary treatment modality, with varying remission rates (52–96.6%) reported across different centres ( 3 ). Various demographic, biochemical, radiological and histopathological
Magnolia Ariza-Nieto, Joshua B Alley, Sanjay Samy, Laura Fitzgerald, Francoise Vermeylen, Michael L Shuler, and José O Alemán
, 19 ). We report that high levels of MIR148A in plasma and low levels in liver DNMT1 mRNA transcripts in liver are related to adiponectin insensitivity in patients following metabolic surgery for weight loss at 12 weeks. Materials and methods
Ida Staby, Jesper Krogh, Marianne Klose, Jonas Baekdal, Ulla Feldt-Rasmussen, Lars Poulsgaard, Jacob Bertram Springborg, and Mikkel Andreassen
Introduction: Patients with pituitary adenomas undergoing transsphenoidal surgery require pre- and post-surgery examination of pituitary hormones. There is currently no consensus on how to evaluate the adrenal axis post-surgery. The aims of this study were to investigate factors that may predict postoperative adrenal insufficiency (AI) and to investigate the overall effect of transsphenoidal surgery on the pituitary function.
Methods: One-hundred-and-forty-three consecutive patients who had undergone transsphenoidal surgery for pituitary adenomas were included. Data on tumour size, pituitary function pre-surgery, plasma basal cortisol measured within 48 hours post-surgery and pituitary function 6 months post-surgery were collected. Patients with AI prior to surgery, perioperative glucocorticoid treatment, Cushing’s disease and no re-evaluation after 1 month were excluded (n=93) in the basal cortisol analysis.
Results: Low plasma basal cortisol post-surgery, tumour size and previous pituitary surgery were predictors of AI (all p<0.05). A basal cortisol cut-off concentration of 300 nmol/L predicted AI 6 months post-surgery with a sensitivity and negative predictive value of 100%, specificity of 81% and positive predictive value of 25%. New gonadal, thyroid and adrenal axis insufficiencies accounted for 2%, 10% and 10%, respectively. The corresponding recovery rates were 17%, 7% and 24%, respectively
Conclusion: Transsphenoidal surgery had an overall beneficial effect on pituitary endocrine function. Low basal plasma cortisol measured within 48 hours after surgery, tumour size and previous surgery were identified as risk factors for AI. Measurement of basal cortisol post-surgery may help identifying patients at risk of developing AI.
Kristin Godang, Karolina Lundstam, Charlotte Mollerup, Stine Lyngvi Fougner, Ylva Pernow, Jörgen Nordenström, Thord Rosén, Svante Jansson, Mikael Hellström, Jens Bollerslev, Ansgar Heck, and the SIPH Study Group
demonstrated improvement of cardiovascular disease or risk factors after surgery ( 3 , 8 , 9 ). Furthermore, it has been demonstrated that PHPT patients with diabetes or dyslipidemia can improve their dysmetabolic status after parathyroidectomy ( 10 , 11
Alberto Giacinto Ambrogio, Massimiliano Andrioli, Martina De Martin, Francesco Cavagnini, and Francesca Pecori Giraldi
surgery but sometimes even decades after cure. Estimates of recurrence vary from 5 to 30% ( 4 , 5 , 6 ) indicating that up to one-fifth of the patients may experience a relapse of hypercortisolism. From a clinical viewpoint, this translates into the need
Cristina Lamas, Elena Navarro, Anna Casterás, Paloma Portillo, Victoria Alcázar, María Calatayud, Cristina Álvarez-Escolá, Julia Sastre, Evangelina Boix, Lluis Forga, Almudena Vicente, Josep Oriola, Jordi Mesa, and Nuria Valdés
timing for surgery, both at initial diagnosis and at recurrence. Hyperplasia affecting all the parathyroid tissue is the most common pathological finding, making recurrences much more frequent than in sporadic hyperparathyroidism, so PHPT often represents