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Open access

Qinglei Yin, Zhou Jin, Yulin Zhou, Dalong Song, Chenyang Fu, Fengjiao Huang, and Shu Wang

Graves’ disease (GD) is a common autoimmune disease that affects the thyroid gland. As a new class of modulators of gene expression, long non-coding RNAs (lncRNAs) have been reported to play a vital role in immune functions and in the development of autoimmunity and autoimmune disease. The aim of this study is to identify lncRNAs in CD4+ T cells as potential biomarkers of GD. lncRNA and mRNA microarrays were performed to identify differentially expressed lncRNAs and mRNAs in GD CD4+ T cells compared with healthy control CD4+ T cells. Quantitative polymerase chain reaction (qPCR) was used to validate the results, and correlation analysis was used to analyze the relationship between these aberrantly expressed lncRNAs and clinical parameters. The microarray identified 164 lncRNAs and 93 mRNAs in GD CD4+ T cells differentially expressed compared to healthy control CD4+ T cells (fold change >2.0 and a P<0.05). Further analysis consistently showed that the expression of HMlincRNA1474 (P<0.01) and TCONS 00012608 (P<0.01) was suppressed, while the expression of AK021954 (P<0.01) and AB075506 (P<0.01) was upregulated from initial GD patients. In addition, their expression levels were recovered in euthyroid GD patients and GD patients in remission. Moreover, these four aberrantly expressed lncRNAs were correlated with GD clinical parameters. Moreover, the areas under the ROC curve were 0.8046, 0.7579, 0.8115 for AK021954, AB075506, HMlincRNA1474, respectively. The present work revealed that differentially expressed lncRNAs were associated with GD, which might serve as novel biomarkers of GD and potential targets for GD treatment.

Open access

Mírian Romitti, Vitor C Fabris, Patricia K Ziegelmann, Ana Luiza Maia, and Poli Mara Spritzer

inflammation and autoimmunity in women with PCOS has been extensively discussed in recent years ( 16 ). Chronic low-grade inflammation might be a relevant connecting link between obesity and metabolic manifestations in PCOS ( 6 , 17 ). After detecting

Open access

A Rouland, J-C Chauvet-Gelinier, A-L Sberna, E Crevisy, P Buffier, T Mouillot, J-M Petit, and B Vergès

be triggered by stress ( 19 , 31 ), we may hypothesize that individuals with Type A personality are more likely to develop auto-immune disorders. This is suggested by our data and it can be speculated that Type A personality and auto-immunity share

Open access

Taís S Assmann, Mariana Recamonde-Mendoza, Bianca M De Souza, and Daisy Crispim

the infiltrating immune system. T1DM development is slow, providing a potentially long window of time in which it is possible to identify and theoretically treat individuals at risk ( 2 , 3 ). The first sign of autoimmunity against beta

Open access

Thabiso R P Mofokeng, Salem A Beshyah, Fazleh Mahomed, Kwazi C Z Ndlovu, and Ian L Ross

), autoimmunity was the major cause across both regions and a predominant cause of PAI in the MENA area compared with SSA. The reported autoimmunity of 20% by the SSA cohort is much lower than was previously found in South Africa, which constituted 50% of the

Open access

Mengxue Yang, Bowen Sun, Jianhui Li, Bo Yang, Jie Xu, Xue Zhou, Jie Yu, Xuan Zhang, Qun Zhang, Shan Zhou, and Xiaohua Sun

intestinal flora play active roles in metabolism, immune development and host defense against pathogens. In addition, these microorganisms participate in intestinal mucosal immunity and autoimmunity, function as key regulators of the immune system, play roles

Open access

Yun Hu, Na Li, Peng Jiang, Liang Cheng, Bo Ding, Xiao-Mei Liu, Ke He, Yun-Qing Zhu, Bing-li Liu, Xin Cao, Hong Zhou, and Xiao-Ming Mao

MC Braverman LE . Thyroglobulin induced lymphocytic thyroiditis in two sublines of BB/Wor rats . Autoimmunity 1991 9 55 – 60 . ( ) 10.3109/08916939108997124 1669847 16 Allen EM Thupari JN

Open access

Aleksandra Gilis-Januszewska, Łukasz Kluczyński, and Alicja Hubalewska-Dydejczyk

the third ventricle, whose inappropriate junctions may impact the hypothalamus function ( 37 ). In recent years, more attention has been put to the link between PTHP and autoimmunity. TBI may induce an inflammation in the nervous system ( 38 , 39

Open access

Xuechao Jiang, Yonghui Wang, Xiaoying Li, Leqi He, Qian Yang, Wei Wang, Jun Liu, and Bingbing Zha

differentiation ( 9 , 10 ). There is emerging evidence that lncRNAs play crucial roles in immune regulation and autoimmunity. T lymphocytes, B lymphocytes, macrophages, dendritic cells, and NK cells all express lncRNAs, which have been shown to be involved in the

Open access

Weiwei He, Bin Wang, Kaida Mu, Jing Zhang, Yanping Yang, Wei Yao, Sheli Li, and Jin-an Zhang

significant associations with dilated cardiomyopathy (DCM) ( 33 ), atrial fibrillation (AF) ( 33 ), allergic rhinitis ( 34 ), pre-eclampsia ( 35 ) and renal cell carcinoma (RCC) ( 36 ). Thyroid autoimmunity is frequently related to polyglandular endocrine