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Qiu-ming Yao, Bin Wang, Xiao-fei An, Jin-an Zhang, and Liumei Ding

more eligible studies, we retrieved the reference lists of relevant articles or reviews. We used the following predefined inclusion criteria: (1) cohort or nested case–control studies; (2) studies assessing T2DM risk associated with testosterone level

Open access

Hiren Patt, Katrin Koehler, Sailesh Lodha, Swati Jadhav, Chaitanya Yerawar, Angela Huebner, Kunal Thakkar, Sneha Arya, Sandhya Nair, Manjunath Goroshi, Hosahithlu Ganesh, Vijaya Sarathi, Anurag Lila, Tushar Bandgar, and Nalini Shah

–phenotype correlation. Herein, we present our series of eight TAS patients from Western India. Additionally, we did systematic review of the published literature, with the aim of analyzing phenotypic and genotypic spectrum of TAS patients worldwide. Patients and

Open access

Yosep Chong, Soon-Jin Ji, Chang Suk Kang, and Eun Jung Lee

use LBP alone or whether LBP should be applied in combination with CS are aspects that are not clear. In this study, we performed a systematic review and meta-analysis of the comparative studies of LBP and CS, mainly on ThinPrep and SurePath methods

Open access

N Bergmann, F Gyntelberg, and J Faber

, these parameters fluctuate, have great inter-individual variability, and reflect mostly acute stress-load (6) . For these reasons, we will not consider the physiological stress-measures as markers of chronic psychosocial stress in this review. Others

Open access

Isabel M Abreu, Eva Lau, Bernardo de Sousa Pinto, and Davide Carvalho

overall cardiovascular risk. Materials and methods Search strategy For the systematic review, a comprehensive search of the Medline database was performed up to September 8th, 2015, using the following query: (thyroid* or hypothyroid*) and

Open access

Liza Haqq, James McFarlane, Gudrun Dieberg, and Neil Smart

insulin-induced metabolic syndrome are also the risk factors that can predispose women with PCOS to cardiovascular disease and type 2 diabetes mellitus (6) . A systematic review was completed in 2011 by Harrison et al . (13) , but presumably as

Open access

Cheng Han Ng, Yip Han Chin, Marcus Hon Qin Tan, Jun Xuan Ng, Samantha Peiling Yang, Jolene Jiayu Kiew, and Chin Meng Khoo

case series to pool evidence in the use of cinacalcet in controlling hypercalcemia from PHPT. Materials and methods Search strategy We adhered to the PRISMA guidelines of the synthesis of this review ( 4 ). Searches were conducted on 5 April

Open access

Salman Razvi, Sanaa Mrabeti, and Markus Luster

The current standard of care for hypothyroidism is levothyroxine (LT4) monotherapy to reduce levels of thyrotropin (thyroid stimulating hormone, TSH) to within its reference range and amelioration of any symptoms. A substantial minority continue to report hypothyroid-like symptoms despite optimised TSH, however. These symptoms are not specific to thyroid dysfunction and are frequent among the euthyroid population, creating a therapeutic dilemma for the treating clinician as well as the patient. We present a concise, narrative review of the clinical research and evidence-based guidance on the management of this challenging population. The clinician may endeavour to ensure that the serum TSH is within the target range. However, the symptomatic patient may turn to alternative non-evidence-based therapies in the hope of obtaining relief. Accordingly, it is important for the clinician to check for conditions unrelated to the thyroid that could account for the ongoing symptoms such as other autoimmune conditions, anaemia or mental health disorders. Systematic and thorough investigation of the potential causes of persistent symptoms while receiving LT4 therapy will resolve the problem for most patients. There may be some patients that may benefit from additional treatment with liothyronine (LT3), although it is unclear as yet as to which patient group may benefit the most from combined LT4 + LT3 therapy. In the future, personalised treatment with LT4 + LT3 may be of benefit for some patients with persistent symptoms of hypothyroidism such as those with polymorphisms in the deiodinase enzyme 2 (DIO2). For now, this remains a subject for research.

Open access

Weixi Wang, Rulai Han, Lei Ye, Jing Xie, Bei Tao, Fukang Sun, Ran Zhuo, Xi Chen, Xiaxing Deng, Cong Ye, Hongyan Zhao, and Shu Wang

clarified. In the current study, we described a MEN1 family with ACC in a cohort of MEN1 patients. Furthermore, we explored the preliminary roles of MEN1 in ACC tumorigenesis and performed a literature review of previously reported cases. Subjects

Open access

Nafiye Helvaci, Erdem Karabulut, Ahmet Ugur Demir, and Bulent Okan Yildiz

reported increased prevalence of OSA in adolescent girls with PCOS compared to age- and BMI-matched controls (16/28 (57%) vs 4/28 (14.3%), P  < 0.01) ( 15 ). This was a retrospective chart review study and study population included adolescent girls with