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E N Dudinskaya, O N Tkacheva, M V Shestakova, N V Brailova, I D Strazhesko, D U Akasheva, O Y Isaykina, N V Sharashkina, D A Kashtanova, and S A Boytsov

ageing and the development of age-related diseases. In addition, insulin resistance (IR) is considered to be a predictor of atherosclerosis and CVD independently of other risk factors, such as blood lipid levels, and hyperglycaemia results in ageing

Open access

Li Jing and Wang Chengji

showed that exercise could decrease the blood sugar and regulate the oxidative stress in the body. Oxidative stress can increase the occurrence and development of complications in diabetic patients, the effect of exercise on the metabolism of metabolites

Open access

Xi Wang and Qi Yu

maturation that is not a result of central activation of the hypothalamic–pituitary–gonadal axis. CPP, which is GnRH-dependent PP, is based on hypothalamic–pituitary–gonadal axis activation associated with progressive pubertal development, accelerated growth

Open access

Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos, and Manuel H Aguiar-Oliveira

the mere accumulation of lipid within hepatocytes (hepatic steatosis, HS), or the inflammation of the liver (nonalcoholic steatohepatitis, NASH), liver fibrosis, or cirrhosis (2) . The evolution of HS to NASH occurs through the development of insulin

Open access

Nicolás Crisosto, Bárbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren, and Teresa Sir-Petermann

daughters of women with PCOS during different stages of development finding several features that may represent early metabolic and reproductive markers of the syndrome and that may be modified through interventions that improve the adverse pregnancy

Open access

L Johnsen, N B Lyckegaard, P Khanal, B Quistorff, K Raun, and M O Nielsen

Introduction Prenatal and early postnatal malnutrition can mediate metabolic programming with life-lasting effects. This represents a risk for development of metabolic diseases later in life, such as obesity and type 2 diabetes ( 1 , 2 , 3

Open access

Eric Seidel, Gudrun Walenda, Clemens Messerschmidt, Benedikt Obermayer, Mirko Peitzsch, Paal Wallace, Rohini Bahethi, Taekyeong Yoo, Murim Choi, Petra Schrade, Sebastian Bachmann, Gerhard Liebisch, Graeme Eisenhofer, Dieter Beule, and Ute I Scholl

2 , a Wnt target gene ( 27 ), and IGF1 , encoding an insulin-like growth factor. IGFs have been implicated in adrenal development ( 28 ) and tumor formation ( 29 ). Genes with downregulated expression included SOAT1 , encoding for sterol

Open access

Florian W Kiefer

that the lipid lysophosphatidylcholine-acyl C16:0 is strongly associated with BAT activity in humans as determined by PET/CT scans ( 83 ). These findings highlight the promising developments in the identification of novel non-invasive markers for the

Open access

Mirjana Kocova, Vesna Janevska, and Violeta Anastasovska

expected stature, obesity, metabolic syndrome and infertility ( 1 , 2 , 4 ). Fertility problems in adult male patients with CAH have been attributed to the development of testicular adrenal rest tumors (TARTs) ( 3 , 4 , 5 ). The migration of adrenal

Open access

Ahmet Uçar, Nurçin Saka, Firdevs Baş, Nihal Hatipoğlu, Rüveyde Bundak, and Feyza Darendeliler

) . Pubertal assessment was done by two pediatric endocrinologists (F Darendeliler and A Uçar) and development staged according to Tanner staging (18) . BW data were retrieved from medical records and they were converted to SDS using national data (19