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Aaron Lerner, Patricia Jeremias, and Torsten Matthias

dysfunctions in thyroid disorders were most recently reviewed ( 11 ). Taken together, a pathogenic role of the intestinal damage, including in CD, is suggested in the development of HT ( 12 , 13 ). Several potential mechanisms were suggested for the gut

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Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, and Anders Juul

). Serious adverse health effects have been associated with high phthalate exposure such as alteration in reproductive development and increased risks of insulin resistance and obesity in human adults ( 8 , 9 , 10 , 11 , 12 ). Importantly, children may be

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Wang Chengji and Fan Xianjin

syndrome, mainly obesity ( 17 ). Other studies have indicated that high baseline PAI-1 levels are associated with incident diabetes ( 18 ) and that PAI-1 levels continue to increase with increasing glucose levels and the development of T2DM ( 19 , 20

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Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, John Vissing, Morten Frost, Knud Bonnet Yderstræde, and Per Heden Andersen

muscle-specific TFAM knockout, peripheral glucose disposal was increased and they did not develop diabetes ( 16 ). These findings do not support mitochondrial dysfunction in skeletal muscle tissue as a primary phenomenon in the development of insulin

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Angela Köninger, Antonella Iannaccone, Ensar Hajder, Mirjam Frank, Boerge Schmidt, Ekkehard Schleussner, Rainer Kimmig, Alexandra Gellhaus, and Hans Dieplinger

development of GDM in patients suffering from PCOS, whereas other parameters like sexual hormone-binding protein (SHBG), fasting insulin and testosterone were not predictive after multivariate analysis ( 14 , 15 ). During the course of a pregnancy, IR

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen, and on behalf of the Growth Hormone Research Society

Introduction Biological markers (biomarkers) play an essential role in the clinical care of patients, drug development and regulatory approval. Furthermore, biomarkers are linked to surrogate endpoints and clinical endpoints ( 1 , 2 , 3 , 4

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Agnieszka Pazderska, Yaasir Mamoojee, Satish Artham, Margaret Miller, Stephen G Ball, Tim Cheetham, and Richard Quinton

Introduction Delayed puberty is defined by the absence of testicular development 2.5 s.d. later than the population mean – typically 14 years of age in males ( 1 ). Although the majority of cases at age 14 have constitutional delay (CDP

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Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader, and Robson Augusto Souza Santos

different models of diabetes and also in different experimental contexts ( 19 , 20 ). Wang and colleagues shed light on the pivotal role of ACE2/Ang(1–7)/Mas axis in organogenesis during embryonic development of pancreatic islets. In this study, the authors

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Paolo G Arduino, Dora Karimi, Federico Tirone, Veronica Sciannameo, Fulvio Ricceri, Marco Cabras, Alessio Gambino, Davide Conrotto, Stefano Salzano, Mario Carbone, and Roberto Broccoletti

average value of 1–2% ( 1 ). The exact aetiology still remains unknown, although immune dysregulation seems to play a critical role in the development and progression of OLP, with such disease being the ultimate outcome of interaction between the immune

Open access

Changwei Liu, Jingwen Wang, Yuanyuan Wan, Xiaona Xia, Jian Pan, Wei Gu, and Mei Li

exhibit immunomodulatory properties and prevent the development of type 1 diabetes in NOD mice, is efficient against apoptosis induced by cytokines in human pancreatic islets in vitro ( 14 ). It inhibits the differentiation and maturation of dendritic