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Monica F Stecchini, Zilda Braid, Candy B More, Davi C Aragon, Margaret Castro, Ayrton C Moreira, and Sonir R Antonini

, but that may be related to the skeletal maturation induced by androgen excess ( 2 ). The development of secondary CPP has been extensively reported in patients with lately diagnosed or poorly controlled congenital adrenal hyperplasia (CAH), and other

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Jennifer K Y Ko, Thomas F J King, Louise Williams, Sarah M Creighton, and Gerard S Conway

Introduction Complete androgen insensitivity syndrome (CAIS) is one of the most common disorders of sex development (DSD) caused by mutations of the androgen receptor gene. The estimated prevalence of AIS is 4.1 per 100,000 live born females

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Marilena Nakaguma, Fernanda A Correa, Lucas S Santana, Anna F F Benedetti, Ricardo V Perez, Martha K P Huayllas, Mirta B Miras, Mariana F A Funari, Antonio M Lerario, Berenice B Mendonca, Luciani R S Carvalho, Alexander A L Jorge, and Ivo J P Arnhold

defects in pituitary development (such as HESX1 , GLI2 , OTX2 ) ( 2 ). The most common genes implicated are those encoding GH1 and GHRHR in IGHD and PROP1 in CPHD, especially in certain geographical regions. Until now, most studies used the

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Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts, and Anders Juul

Introduction Testosterone (T) promotes maturation of the male reproductive organs, development of secondary sex characteristics and production of sperm by the testes. In puberty in boys, pulsatile gonadotropin stimulation upon reactivation of

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Antonia Ertelt, Ann-Kristin Barton, Robert R Schmitz, and Heidrun Gehlen

Federation (IDF), the waist circumference has to be measured at ≥80 cm in women and ≥94 cm in men ( http://www.idf.org , 09/08/2011). Mesenteric and omental fat is of greater importance in the development of insulin resistance, because their fatty acids and

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Elena Galazzi, Paolo Duminuco, Mirella Moro, Fabiana Guizzardi, Nicoletta Marazzi, Alessandro Sartorio, Sabrina Avignone, Marco Bonomi, Luca Persani, and Maria Teresa Bonati

Introduction The TBX3 gene encodes a member of the T-box family of transcription factors acting as a repressor of target gene expression. Tbx3 has a role in the specification of posterior limb mesoderm and in the development of the dorso

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Nassim Ghaffari-Tabrizi-Wizsy, Christina Angelika Passegger, Laura Nebel, Fabian Krismer, Gudrun Herzer-Schneidhofer, Gert Schwach, and Roswitha Pfragner

): Fertilised white Lohmann chicken eggs (from local provider) were incubated at 37°C and 60% humidity. The egg shells were cracked on day 3 of embryonic development and the embryos were incubated in a sterile dish for further application. On day 10 of embryonic

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Rossella Cannarella, Teresa Mattina, Rosita A Condorelli, Laura M Mongioì, Giuseppe Pandini, Sandro La Vignera, and Aldo E Calogero

could not be evaluated because he was not alive. The patient sister had a normal psychophysical development, and she did not show overgrowth. Patient two Patient 2 was a 16-year-old male, admitted for the first time to the Department of

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Kristin Ottarsdottir, Anna G Nilsson, Margareta Hellgren, Ulf Lindblad, and Bledar Daka

recent study of over 2000 community-dwelling middle-aged to elderly men, and with a 5-year follow-up, similar results were found – low total testosterone concentrations predicted the development of type 2 diabetes ( 23 ). However, another prospective

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Masafumi Tetsuka and Misato Tanakadate

(PGE2) in cumulus cells ( 5 , 6 , 7 , 8 ). These hormones have been shown to play various roles in regulating the expression of many factors associated with oocyte maturation, fertilization and subsequent embryo development and cumulus expansion ( 8