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Qinglei Yin, Zhou Jin, Yulin Zhou, Dalong Song, Chenyang Fu, FengJiao Huang, and Shu Wang

altered numbers and defective suppressor function in GD patients ( 10 , 11 ). These findings suggest the dysfunction of CD4+ T cells play an important role in the pathogenesis of GD development. However, the potential mechanisms underlying CD4+ T cell

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Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar, and Tomasz Francuz

.113 ) 10.1038/modpathol.2014.113 9 Lengyel E . Ovarian cancer development and metastasis . American Journal of Pathology 2010 177 1053 – 1064 . ( doi:10.2353/ajpath.2010.100105 ) 10.2353/ajpath.2010.100105 10 Weidle UH Birzele F

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Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Guiyang Jiang, Takuro Goto, Yujiro Nagata, George J Netto, and Hiroshi Miyamoto

treatment such as radical cystectomy with neoadjuvant/adjuvant chemotherapy. Accordingly, identifying key molecules/pathways responsible for the development and/or growth of urothelial tumor may offer novel targeted therapy that improves patient outcomes

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Elizaveta Mamedova, Natalya Mokrysheva, Evgeny Vasilyev, Vasily Petrov, Ekaterina Pigarova, Sergey Kuznetsov, Nikolay Kuznetsov, Liudmila Rozhinskaya, Galina Melnichenko, Ivan Dedov, and Anatoly Tiulpakov

( 5 ). PHPT development at an early age is suspicious for hereditary causes, but whether routine mutational analysis among young patients with PHPT, for example for MEN1 mutations, is needed and under what age it is advisable remains controversial

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Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag, and Henriette Kirchner

, ranging from steatosis with normal hepatic function to nonalcoholic steatohepatitis (NASH) and further to cirrhotic NASH and even hepatocellular carcinoma (for review see ( 1 )). Several endocrine pathways are known to contribute to the development and

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Agnieszka Adamska, Aleksandra Maria Polak, Anna Krentowska, Agnieszka Łebkowska, Justyna Hryniewicka, Monika Leśniewska, and Irina Kowalska

dysfunction and characteristic image of the ovaries in the ultrasound ( 2 ). A lot of data indicated that insulin resistance is a key factor in the development of metabolic disturbances in PCOS, for example, obesity, type 2 diabetes (T2D), cardiovascular

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Riying Liang, Meijun Wang, Chang Fu, Hua Liang, Hongrong Deng, Ying Tan, Fen Xu, and Mengyin Cai

Introduction Chronic kidney disease (CKD) is increasing worldwide, and obesity is a major risk factor for the development of CKD ( 1 , 2 ) that could be independent of hypertension, diabetes, and dyslipidemia ( 3 ). The pathological features

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H A Booij, W D C Gaykema, K A J Kuijpers, M J M Pouwels, and H M den Hertog

stalk at the time of injury ( 4 ). This, and other secondary mechanisms after TBI, such as hypotension, hypoxia and raised intracranial pressure might be responsible for the development of PD ( 5 ). The same concept might be applied in part to brain

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L M Mongioì, R A Condorelli, S La Vignera, and A E Calogero

3912 – 3922 . ( ) 10.1210/jc.2007-0685 14 Løvås K Curran S Oksnes M Husebye ES Huppert FA Chatterjee VK. Development of a disease-specific quality of life questionnaire in Addison’s disease . Journal of Clinical

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A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, and Timothy J Cole

all stages of ovarian follicle development ( Fig. 5A and D ). Also shown are negative controls with no primary antibody (panel B) and an immunizing peptide, pre-incubation control (panel C). The mouse ovary, that should not express a HSD1L protein