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Kathryn L Gatford, Beverly S Muhlhausler, Lili Huang, Pamela Su-Lin Sim, Claire T Roberts, Johannes D Velhuis, and Chen Chen

important role for GH for maternal adaptations to pregnancy and placental development is conserved across multiple species. The timing of increased basal secretion from mid-pregnancy suggests regulation of pituitary secretion by a placenta-derived factor

Open access

María L Bacigalupo, Verónica G Piazza, Nadia S Cicconi, Pablo Carabias, Andrzej Bartke, Yimin Fang, Ana I Sotelo, Gabriel A Rabinovich, María F Troncoso, and Johanna G Miquet

somatotropic axis have been implicated in the development of liver tumors in rodents. While GH-deficient mice are resistant to the development of carcinogen-induced liver tumors ( 10 ), transgenic mice overexpressing GH spontaneously develop hepatocellular

Open access

Masatada Watanabe, Shuji Ohno, and Hiroshi Wachi

cells were obtained from the Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University (Sendai, Japan). The cells were cultured in RPMI-1640 (Wako Pure Chemical Industries) supplemented with 10% fetal

Open access

Borros Arneth

pathogenesis or whether their appearance represents a major step in disease development, and this topic remains controversial in the extant literature ( 15 , 16 ). In addition, the presence of autoantibodies could indicate a non-specific, bystander autoimmune

Open access

Xinlei Chen, Liru Hu, Caojie Liu, Guangcheng Ni, and Yuwei Zhang

Owing to the development of imaging techniques and improved patient awareness, there is an increasing tendency toward incidentally discovered PPGL. Considering that no statistically significant differences were found in hormonal secretion and malignancy

Open access

Qinglei Yin, Zhou Jin, Yulin Zhou, Dalong Song, Chenyang Fu, FengJiao Huang, and Shu Wang

altered numbers and defective suppressor function in GD patients ( 10 , 11 ). These findings suggest the dysfunction of CD4+ T cells play an important role in the pathogenesis of GD development. However, the potential mechanisms underlying CD4+ T cell

Open access

Ling Zhou, Zhexin Ni, Wen Cheng, Jin Yu, Shuai Sun, Dongxia Zhai, Chaoqin Yu, and Zailong Cai

IR, promoting the development of PCOS ( 2 ). The interrelation between gut microbiota and PCOS is attracting increased attention. Compared with healthy women, Lindheim et al . ( 3 ) found that the abundance of ML615J-28 and 124-7 from phylum

Open access

Peter Ergang, Anna Mikulecká, Martin Vodicˇka, Karla Vagnerová, Ivan Mikšík, and Jirˇí Pácha

determine (i) whether social stress influences the local metabolism of glucocorticoids in primary and secondary lymphoid organs, i.e. in the structures where immune cells undergo development and activation and (ii) whether there is any strain predisposition

Open access

Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar, and Tomasz Francuz

.113 ) 10.1038/modpathol.2014.113 9 Lengyel E . Ovarian cancer development and metastasis . American Journal of Pathology 2010 177 1053 – 1064 . ( doi:10.2353/ajpath.2010.100105 ) 10.2353/ajpath.2010.100105 10 Weidle UH Birzele F

Open access

Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Guiyang Jiang, Takuro Goto, Yujiro Nagata, George J Netto, and Hiroshi Miyamoto

treatment such as radical cystectomy with neoadjuvant/adjuvant chemotherapy. Accordingly, identifying key molecules/pathways responsible for the development and/or growth of urothelial tumor may offer novel targeted therapy that improves patient outcomes