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Borros Arneth

pathogenesis or whether their appearance represents a major step in disease development, and this topic remains controversial in the extant literature ( 15 , 16 ). In addition, the presence of autoantibodies could indicate a non-specific, bystander autoimmune

Open access

Masatada Watanabe, Shuji Ohno, and Hiroshi Wachi

cells were obtained from the Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University (Sendai, Japan). The cells were cultured in RPMI-1640 (Wako Pure Chemical Industries) supplemented with 10% fetal

Open access

Xinlei Chen, Liru Hu, Caojie Liu, Guangcheng Ni, and Yuwei Zhang

Owing to the development of imaging techniques and improved patient awareness, there is an increasing tendency toward incidentally discovered PPGL. Considering that no statistically significant differences were found in hormonal secretion and malignancy

Open access

Peter Ergang, Anna Mikulecká, Martin Vodicˇka, Karla Vagnerová, Ivan Mikšík, and Jirˇí Pácha

determine (i) whether social stress influences the local metabolism of glucocorticoids in primary and secondary lymphoid organs, i.e. in the structures where immune cells undergo development and activation and (ii) whether there is any strain predisposition

Open access

Ling Zhou, Zhexin Ni, Wen Cheng, Jin Yu, Shuai Sun, Dongxia Zhai, Chaoqin Yu, and Zailong Cai

IR, promoting the development of PCOS ( 2 ). The interrelation between gut microbiota and PCOS is attracting increased attention. Compared with healthy women, Lindheim et al . ( 3 ) found that the abundance of ML615J-28 and 124-7 from phylum

Open access

Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar, and Tomasz Francuz

.113 ) 10.1038/modpathol.2014.113 9 Lengyel E . Ovarian cancer development and metastasis . American Journal of Pathology 2010 177 1053 – 1064 . ( doi:10.2353/ajpath.2010.100105 ) 10.2353/ajpath.2010.100105 10 Weidle UH Birzele F

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Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Guiyang Jiang, Takuro Goto, Yujiro Nagata, George J Netto, and Hiroshi Miyamoto

treatment such as radical cystectomy with neoadjuvant/adjuvant chemotherapy. Accordingly, identifying key molecules/pathways responsible for the development and/or growth of urothelial tumor may offer novel targeted therapy that improves patient outcomes

Open access

Elizaveta Mamedova, Natalya Mokrysheva, Evgeny Vasilyev, Vasily Petrov, Ekaterina Pigarova, Sergey Kuznetsov, Nikolay Kuznetsov, Liudmila Rozhinskaya, Galina Melnichenko, Ivan Dedov, and Anatoly Tiulpakov

( 5 ). PHPT development at an early age is suspicious for hereditary causes, but whether routine mutational analysis among young patients with PHPT, for example for MEN1 mutations, is needed and under what age it is advisable remains controversial

Open access

Agnieszka Adamska, Aleksandra Maria Polak, Anna Krentowska, Agnieszka Łebkowska, Justyna Hryniewicka, Monika Leśniewska, and Irina Kowalska

dysfunction and characteristic image of the ovaries in the ultrasound ( 2 ). A lot of data indicated that insulin resistance is a key factor in the development of metabolic disturbances in PCOS, for example, obesity, type 2 diabetes (T2D), cardiovascular

Open access

Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag, and Henriette Kirchner

, ranging from steatosis with normal hepatic function to nonalcoholic steatohepatitis (NASH) and further to cirrhotic NASH and even hepatocellular carcinoma (for review see ( 1 )). Several endocrine pathways are known to contribute to the development and