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Juan Carlos Juárez-Cruz, Miriam Daniela Zuñiga-Eulogio, Monserrat Olea-Flores, Eduardo Castañeda-Saucedo, Miguel Ángel Mendoza-Catalán, Carlos Ortuño-Pineda, Ma Elena Moreno-Godínez, Sócrates Villegas-Comonfort, Teresita Padilla-Benavides, and Napoleón Navarro-Tito

, which further enhances the predisposition of developing breast tumors ( 4 ). Among these molecules, leptin is one of the most important adipokines involved in the development and progression of mammary tumors ( 5 ). Leptin is a hormone with a molecular

Open access

Selina Mäkinen, Yen H Nguyen, Paulina Skrobuk, and Heikki A Koistinen

to ROS production ( 18 ), we next analysed if development of insulin resistance of glucose uptake is related to ROS. Human myotubes were exposed for 12 h to palmitate, oleate or their combination. Mitochondrial ROS production was significantly

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Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Matthias B Schulze, Heiner Boeing, and Krasimira Aleksandrova

-scale prospective population-based studies exist to support or refute generated hypothesis on chemerin involvement in disease development. Important prerequisite for planning biomarker assessment in a prospective study is the assessment of whether single biomarker

Open access

K L Gatford, G K Heinemann, S D Thompson, J V Zhang, S Buckberry, J A Owens, G A Dekker, C T Roberts, and on behalf of the SCOPE Consortium

Introduction The insulin-like growth factors (IGFs), IGF1 and IGF2, are important regulators of placental and foetal development, as well as postnatal growth and metabolism. In humans, circulating IGF1 peaks in adolescence and then falls with age

Open access

B Shahida, P Sahlstrand Johnson, R Jain, H Brorson, P Åsman, M Lantz, and T Planck

Introduction Autoimmune thyroid disease is a prerequisite for the development of Graves’ ophthalmopathy (GO), and both thyroid and orbital tissues are infiltrated by immunocompetent cells. The thyroid-stimulating hormone receptor (TSHR) acts

Open access

Stefano Mangiola, Ryan Stuchbery, Patrick McCoy, Ken Chow, Natalie Kurganovs, Michael Kerger, Anthony Papenfuss, Christopher M Hovens, and Niall M Corcoran

–20%, respectively ( 8 , 10 ). The promotion of an obese-like phenotype by androgen deprivation is highly clinically relevant, as obesity (expressed as BMI) is itself associated with the development of prostate cancer, post-prostatectomy biochemical failure and

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Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel, and André P van Beek

has been observed ( 36 ). This suggests that the development of hypoglycaemia unawareness cannot be attributed to a specific type of bariatric surgery. The discrepancy between the asymptomatic low blood sugars in our study and the development of

Open access

Melissa Braga, Zena Simmons, Keith C Norris, Monica G Ferrini, and Jorge N Artaza

Introduction Vitamin D is universally recognized for its classical effects on calcium regulation and phosphate homeostasis, in relation to bone development and maintenance ( 1 , 2 ). However, vitamin D deficiency has also been linked to the

Open access

Kathryn L Gatford, Beverly S Muhlhausler, Lili Huang, Pamela Su-Lin Sim, Claire T Roberts, Johannes D Velhuis, and Chen Chen

important role for GH for maternal adaptations to pregnancy and placental development is conserved across multiple species. The timing of increased basal secretion from mid-pregnancy suggests regulation of pituitary secretion by a placenta-derived factor

Open access

María L Bacigalupo, Verónica G Piazza, Nadia S Cicconi, Pablo Carabias, Andrzej Bartke, Yimin Fang, Ana I Sotelo, Gabriel A Rabinovich, María F Troncoso, and Johanna G Miquet

somatotropic axis have been implicated in the development of liver tumors in rodents. While GH-deficient mice are resistant to the development of carcinogen-induced liver tumors ( 10 ), transgenic mice overexpressing GH spontaneously develop hepatocellular