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Li Jing and Wang Chengji

filtration system. On the other hand, the non-invasive collection of urine is conducive to many metabolomic applications. Metabolomics enables the systematic assessment of the abundant changes of low-molecular-weight compounds present in biological samples

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Jia Li, Yan Zhao, Caoxin Huang, Zheng Chen, Xiulin Shi, Long Li, Zhong Chen, and Xuejun Li

, physical activity has shown a reduction in diabetes and cardiovascular diseases (35 and 49%, respectively) among NAFLD patients ( 5 , 6 ). Metabolomics is a high-throughput technology that can measure thousands of metabolites (in biological fluids or

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Charlotte Höybye, Erik Wahlström, Petra Tollet-Egnell, and Gunnar Norstedt

Introduction Metabolomics is an exciting new analytical field in systems biology, which uses techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy to define the pattern of low-molecular weight compounds (LMCs

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Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska, and Ze’ev Hochberg

subject’s unique metabolic fingerprint and offers means of metabolomic phenotyping at the individual level ( 9 , 10 ). Thus, each individual has a unique ‘steroidal fingerprint’. A cluster of similar ‘steroidal fingerprints’ related to a disease would be

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Jintao Hu, Qingbo Chen, Xiao Ding, Xin Zheng, Xuefeng Tang, Song Li, and Hui Yang

. Pathway enrichment of the changed metabolites also indicated significant changes in the purine and pyrimidine metabolic pathways (Supplementary Fig. 3). Figure 5 Metabolomics analysis of GH3 cells cultured in a medium containing Gln (N, with 2 mM Gln

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Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse, and Paul-Martin Holterhus

. ( doi:10.1159/000346406 ) 32 Gawlik A Shmoish M Hartmann MF Malecka-Tendera E Wudy SA Hochberg Z. Steroid metabolomic disease signature of nonsyndromic childhood obesity . Journal of Clinical Endocrinology and Metabolism

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Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp, and Evgeni Levin

:// ) 10.1016/j.cmet.2016.06.016 27411009 12 Fu J Schoeman JC Harms AC van Wietmarschen HA Vreeken RJ Berger R Cuppen BVJ Lafeber FPJG van der Greef J Hankemeier T. Metabolomics profiling of the free and

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Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton, and Heather B Patisaul

adipogenesis. To probe these and other possible modes of action including disruption of 5-HT production and placental inflammation, we employed a diverse range of hypothesis-generating (RNA sequencing and untargeted metabolomics) and targeted (quantitative real

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Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer, and Irvin M Modlin

(67%), metabolomics (75%) and circulating mRNA (80%). In general, circulating tumor cells (CTCs) were agreed not to be reliable, sensitive or specific for the detection (88% no) and diagnosis (92% no) of NENs. Furthermore, once tumors were

Open access

Yiqiong Ma, Zhaowei Chen, Yu Tao, Jili Zhu, Hongxia Yang, Wei Liang, and Guohua Ding

ROS levels are mainly generated by the podocytes ( 19 ). In DN patients, urinary exosomes and renal biopsy metabolomics analysis revealed that the expression of multiple regulatory factors associated with mitochondrial metabolism were decreased, such