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Earn H Gan, Wendy Robson, Peter Murphy, Robert Pickard, Simon Pearce, and Rachel Oldershaw

capacity of rodent adrenal capsule nearly 80 years ago ( 4 ), the exact in vivo identity of adrenocortical stem cells (ACSCs) remains elusive. Adult mesenchymal stromal or stem cells (MSCs) have drawn significant interest among researchers in the stem

Open access

Melissa Braga, Zena Simmons, Keith C Norris, Monica G Ferrini, and Jorge N Artaza

muscle stem cells’, have a remarkable ability to regenerate after muscle injury and are responsible for compensation of muscle turnover caused by daily wear and tear. In this study, we expand our previous results and conclusions ( 11 , 12 ) by now

Open access

Luminita Nicoleta Cima, Anca Colita, and Simona Fica

Introduction Hematopoietic stem cell transplantation (HSCT) is increasingly used for the treatment of both malignant and nonmalignant diseases. Survival after autologous/allogeneic HSCT is no longer the highest concern, as many patients

Open access

Sidsel Mathiesen, Kaspar Sørensen, Marianne Ifversen, Casper P Hagen, Jørgen Holm Petersen, Anders Juul, and Klaus Müller

Introduction Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for children with life-threatening hematological and immunological diseases, including high-risk leukemias, but late effects are becoming prevalent

Open access

Veronica Astro, Elisabetta Fiacco, Kelly Johanna Cardona-Londoño, Ilario De Toma, Hams Saeed Alzahrani, Jumana Alama, Amal Kokandi, Taha Abo-Almagd Abdel-Meguid Hamoda, Majed Felemban, and Antonio Adamo

North American (ENA) KS- and high-grade SCA patient-derived induced pluripotent stem cells (iPSCs) ( 10 , 11 , 12 , 13 , 14 , 15 ). Here, we present the first iPSC-based disease-modeling study performed on KS patients from Saudi Arabia. Saudi Arabia

Open access

Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka, and Rod T Mitchell

Introduction Fertility in males is dependent on the presence of a germ cell population that is capable of developing into sperm in adulthood. However, the ability of spermatogonial stem cells (SSC) to give rise to sperm is dependent on the

Open access

Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, and Valeria Sordi

variability of isolated human islets and the need for lifelong immunosuppression. Different approaches using stem cells to support islet survival and function are being explored in preclinical and clinical settings ( 5 ). Now, the most advanced strategies to

Open access

Wenrui Wang and Chuan Zhang

, native stem cells can supplement the increased demand for antral insulin + cells and provide an excellent source of functional β-like cells. Antral endocrine cells mediated by PMN can be effectively reprogrammed into insulin + cells, with robust

Open access

Ashley N Reeb, Andrea Ziegler, and Reigh-Yi Lin

THJ-16T. In these studies, we achieved a 100% tumor take rate ( 11 , 13 ). We have also used NSG mice to confirm the presence of a rare subpopulation of cancer stem cells in the ATC cell lines ( 14 ). In this study, all three human FTC cell lines

Open access

Klaus W Fagerstedt, Tom Böhling, Harri Sihto, Tarja Salonen, Fang Zhao, Mia Kero, Leif C Andersson, and Johanna Arola

exocrine and endocrine portions of the tumor are derived from the bidirectional differentiation of a common stem cell ( 8 , 9 , 10 , 11 ). Stanniocalcin 1 (STC1) is a 56-kD homodimeric protein with autocrine and paracrine functions that protect cells