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Julie Refardt, Clara Odilia Sailer, Bettina Winzeler, Matthias Johannes Betz, Irina Chifu, Ingeborg Schnyder, Martin Fassnacht, Wiebke Fenske, Mirjam Christ-Crain, and for the CODDI-Investigators

Introduction Polyuria polydipsia syndrome is a common problem in clinical practice with the two main entities being primary polydipsia and central diabetes insipidus ( 1 ). While the pathomechanism of central diabetes insipidus is well known

Open access

Laura Potasso, Julie Refardt, Irina Chifu, Martin Fassnacht, Wiebke Kristin Fenske, and Mirjam Christ-Crain

infusions for the differential diagnosis of DI ( 11 ), we aimed to investigate the course of plasma potassium levels during a standardized hypertonic saline infusion test with 3% saline in a large cohort of healthy volunteers and patients with polyuria–polydipsia

Open access

M de Fost, S M Oussaada, E Endert, G E Linthorst, M J Serlie, M R Soeters, J H DeVries, P H Bisschop, and E Fliers

. ( doi:10.1172/JCI107423 ). 6 Fenske W Quinkler M Lorenzo D Zopf K Haagen U Papassotiriou J Pfeiffer AF Fassnacht M Störk S Allolio B . Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome – revisiting the direct

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Clara Odilia Sailer, Sophia Julia Wiedemann, Konrad Strauss, Ingeborg Schnyder, Wiebke Kristin Fenske, and Mirjam Christ-Crain

volunteers with available plasma samples ( 15 ). Inclusion criteria were normonatremia (serum sodium levels of 135–145 mmol/L) and age >18 years. Exclusion criteria included a history or presence of polyuria/polydipsia syndrome (24 urinary volume output >50

Open access

Aida Javanbakht, Massimo D’Apuzzo, Behnam Badie, and Behrouz Salehian

). Symptoms vary from nonspecific manifestation, such as fatigue and headache, to more specific symptoms of polyuria and polydipsia. The frequent absence or nonspecific nature of Pit Met symptoms makes diagnosis difficult delaying detection of early

Open access

C E Higham, A Olsson-Brown, P Carroll, T Cooksley, J Larkin, P Lorigan, D Morganstein, P J Trainer, and the Society for Endocrinology Clinical Committee

, intractable headache. If methylprednisolone or other pharmacological dose glucocorticoids are administered for this or other non-endocrine immune complications, additional hydrocortisone is not required. If significant polyuria, polydipsia and

Open access

David C Llewellyn, Rajaventhan Srirajaskanthan, Royce P Vincent, Catherine Guy, Eftychia E Drakou, Simon J B Aylwin, Ashley B Grossman, John K Ramage, and Georgios K Dimitriadis

and stimulate her appetite. While in clinic, she reported significant polydipsia and polyuria, and her serum blood glucose was 21 mmol/L. She was admitted for urgent inpatient management of steroid-induced diabetes. While an inpatient, she was also

Open access

Rui Zhang, Xinmei Huang, Yue Li, Zhiyan Yu, Yueyue Wu, Bingbing Zha, Heyuan Ding, Shufei Zang, and Jun Liu

participants provided informed consent. Diabetes was confirmed by OGTT (oral glucose tolerance test) based on the diagnostic criteria recommended by the American Diabetes Association, 1997: (i) typical symptoms of diabetes (polydipsia, polyuria, polyphagia, and

Open access

Maria Stelmachowska-Banaś and Izabella Czajka-Oraniec

the demographics of patients receiving ICIs ( 88 , 89 ). In most cases, the clinical presentation showed a severe course. Patients with ICI-related DM often present with signs and symptoms of hyperglycemia (polyuria, polydipsia, and weight loss) or