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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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increased risk of diabetes mellitus (DM) due to the sedentary lifestyle and adiposity of COPD patients, the inflammatory processes ( 2 ), and the treatment adverse effects associated with the use of high-dose corticosteroids ( 3 ). On the other hand
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University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland
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1982 55 757 – 761 . ( https://doi.org/10.1210/jcem-55-4-757 ) 3 Krieger DT Allen W Rizzo F & Krieger HP . Characterization of the normal temporal pattern of plasma corticosteroid levels . Journal of Clinical Endocrinology and Metabolism
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. The disease course is chronic, although spontaneous healing is observed in about 10–20% of cases after 6–12 years. Systemic medications such as ciclosporin A, adalimumab, fumaric acid and corticosteroids may be used therapeutically. Treatment of the
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Introduction Prednisolone, a corticosteroid-based drug, is used in a wide range of diseases due to its anti-inflammatory and immunosuppressant effects ( 1 , 2 , 3 , 4 ). Glucocorticoids affect various human tissues, and it has been shown
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. Furthermore, in order to exclude the potential effects on growth, children with other autoimmune complications or genetic disorders, patients with chronic diseases (i.e. celiac disease, thyroid abnormalities), or using corticosteroid therapy or with genetic
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controls had not received any immunomodulatory or corticosteroid drugs. The patients with type 2 diabetes and healthy controls were matched for age, sex, and BMI to ensure comparability. This study protocol was approved by the ethics committee of Tsinghua
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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, steroid-induced diabetes, post-transplant diabetes, hepatitis, corticosteroid therapy, active neoplasia, and ongoing shift work. The participants were asked to follow a moderate diet without excess fat or alcohol intake, 24 h prior to the testing day
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viral hepatitis and alcoholic hepatitis; (vi) chronic kidney diseases, and estimated glomerular filtration rate(eGFR)<60 mL/min/1.73 m 2 ; (vii) hyperthyroidism or hypothyroidism; (viii) current treatment with systemic corticosteroids; (ix) recent use of