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regulated by androgens, and testosterone supplementation reduces the protein level of FOXO1 ( 17 ). In addition to through FOXO1 to modulate PEPCK, AR can also directly inhibit the expression and activity of PEPCK, along with increased fasting glucose levels
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Clinical Chemistry System (Siemens Medical Solutions). Insulin was measured using a solid-phase enzyme-amplified sensitivity immunoassay (INS-EASIA; Biosource Technologies, Nivelles, Belgium). Total testosterone was measured by ELISA (testosterone enzyme
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stress, insulin resistance, metabolic syndrome, and type 2 diabetes ( 36 , 37 ). Antioxidant steroids, such as estrogen or testosterone, could enhance MPO activity and improve bacterial killing activity of polymorphonuclear leukocytes ( 38 , 39 ). MPO
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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healthy counterparts, and its circulating levels were further augmented in the presence of diabetes ( 6 ). Considering these data, and despite the fact that the levels of sex hormones, such as testosterone and estradiol, may influence the development of
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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total testosterone <10 nmol/L (2.88 ng/mL) (results available in 20 of 21 male patients); e Renal impairment was defined as eGFR <60 m/min/1.73 m 2 and/or >30 mg albumin/g creatinine in spot urine. However, only 1 patient had an eGFR <60 mL/min/1.73 m
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2016 101 2218 – 2225 . ( https://doi.org/10.1210/jc.2016-1076 ) 16 Chen Y Chen Y Xia F Wang N Chen C Nie X Li Q Han B Zhai H Jiang B A higher ratio of estradiol to testosterone is associated with autoimmune thyroid disease in males
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androgen levels in femalesand low testosterone levels in males and marked obesity. Other problems include cardiac abnormalities such as dilated cardiomyopathies, progressive heart failure and slowly progressive renal failure coupled with haemorrhagic
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increased risk of developing osteoporosis due to the diminished protective effect of oestrogen after menopause. Nonetheless, the gender differences between hepatic fibrosis and osteoporosis were not clear. Gonadal hormones including testosterone (T