Qiu-ming Yao
Qiu-ming Yao
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Bin Wang
Bin Wang
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Xiao-fei An
Xiao-fei An
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Jin-an Zhang
Jin-an Zhang
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Liumei Ding
Liumei Ding
Department of Clinical Laboratory, Jinshan Hospital of Fudan University, Shanghai, China
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T2DM are still necessary to copy with the epidemic of T2DM. There is evidence to indicate that endogenous sex hormones play a vital role in the pathogenesis of T2DM ( 4 ). Some studies proposed that testosterone was possibly linked with T2DM risk
Jin Kyu Oh
Jin Kyu Oh
Department of Urology, College of Medicine, Gachon University, Incheon, Republic of Korea
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Young Jae Im
Young Jae Im
Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea
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Kwanjin Park
Kwanjin Park
Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea
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Jae-Seung Paick
Jae-Seung Paick
Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea
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, albeit with no hypospadias, as indicated by normal morphology of the urethral meatus at the tip of the glans penis. Micropenis is commonly associated with testosterone deficiencies from 12 weeks of gestation, with normal placental human chorionic
Mélanie Rouleau
Mélanie Rouleau
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Francis Lemire
Francis Lemire
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Michel Déry
Michel Déry
Biochemistry Service, Medical Laboratory Department, CHU de Québec-Université Laval, Québec, Québec, Canada
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Benoît Thériault
Benoît Thériault
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Gabriel Dubois
Gabriel Dubois
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Yves Fradet
Yves Fradet
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Paul Toren
Paul Toren
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Chantal Guillemette
Chantal Guillemette
Pharmacy Faculty, Université Laval and CHU de Québec-Université Laval, Québec, Québec, Canada
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Louis Lacombe
Louis Lacombe
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Laurence Klotz
Laurence Klotz
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
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Fred Saad
Fred Saad
Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada
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Dominique Guérette
Dominique Guérette
Biochemistry Service, Medical Laboratory Department, CHU de Québec-Université Laval, Québec, Québec, Canada
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Frédéric Pouliot
Frédéric Pouliot
Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada
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Introduction Androgen deprivation therapy (ADT) is used to treat recurrent and advanced PCa ( 1 , 2 ). ADT blocks the testicular production of androgens thus inhibiting PCa cell growth ( 3 ). Serum testosterone levels are a prognostic factor
Claire L Wood
Claire L Wood
Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Kieren G Hollingsworth
Kieren G Hollingsworth
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Edrina Bokaie
Edrina Bokaie
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Eric Hughes
Eric Hughes
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Robert Muni-Lofra
Robert Muni-Lofra
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Anna Mayhew
Anna Mayhew
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Rod T Mitchell
Rod T Mitchell
MRC Centre for Reproductive Health, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
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Michela Guglieri
Michela Guglieri
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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Joseph McElvaney
Joseph McElvaney
Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
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Timothy D Cheetham
Timothy D Cheetham
Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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Volker Straub
Volker Straub
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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, however, can result in many adverse effects including pubertal delay. Recent work at our centre has shown that incremental monthly testosterone injections can induce puberty in adolescents with DMD and delayed puberty ( 3 ). The 2-year testosterone regimen
Peter Bond
Peter Bond
Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands
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Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands
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Tijs Verdegaal
Tijs Verdegaal
Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands
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Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands
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Diederik L Smit
Diederik L Smit
Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands
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Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands
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Introduction Testosterone therapy (TTh) is prescribed to hypogonadal men to correct testosterone levels and alleviate symptoms that result from its deficiency. Benefits include improved sexual function and quality of life ( 1 ), improvements
Lawrence D Hayes
Lawrence D Hayes
Active Ageing Research Group, Department of Medical and Sport Sciences, University of Cumbria, Lancaster, UK
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Peter Herbert
Peter Herbert
School of Sport, Health and Outdoor Education, Trinity Saint David, University of Wales, Carmarthen, UK
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Nicholas F Sculthorpe
Nicholas F Sculthorpe
Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, UK
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Fergal M Grace
Fergal M Grace
Faculty of Health, Federation University, Victoria, Australia
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Introduction Testosterone is a sex steroid hormone with profound influence on various tissues ( 1 , 2 , 3 ). The precipitous decline in systemic testosterone with age is well described ( 4 ). Additionally, sex hormone-binding globulin (SHBG
Christian Høst
Christian Høst
Department of Endocrinology and Internal Medicine and the Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Aarhus N, Denmark
Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark
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Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark
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Anders Bojesen
Anders Bojesen
Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark
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Mogens Erlandsen
Mogens Erlandsen
Section for Biostatistics, Department of Public Health, Aarhus University, Aarhus C, Denmark
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Kristian A Groth
Kristian A Groth
Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark
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Kurt Kristensen
Kurt Kristensen
Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark
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Anne Grethe Jurik
Anne Grethe Jurik
Department of Radiology, Aarhus University Hospital, Aarhus N, Denmark
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Niels H Birkebæk
Niels H Birkebæk
Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark
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Claus H Gravholt
Claus H Gravholt
Department of Endocrinology and Internal Medicine and the Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Aarhus N, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark
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, with increased fasting insulin levels ( 8 ). At the same time cross-sectional studies have shown an inverse relationship between plasma testosterone and insulin resistance in normal males ( 9 ). We previously found that the increased occurrence of
Nandini Shankara Narayana
Nandini Shankara Narayana
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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Lam P Ly
Lam P Ly
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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Veena Jayadev
Veena Jayadev
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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Carolyn Fennell
Carolyn Fennell
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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Sasha Savkovic
Sasha Savkovic
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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Ann J Conway
Ann J Conway
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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David J Handelsman
David J Handelsman
Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia
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Introduction Since the discovery and first clinical use of testosterone in the 1930s, its minimal oral bioavailability has led to administration via every non-oral route to circumvent rapid gut and liver metabolism ( 1 ). Since the 1950s, the
P Herbert
P Herbert
School of Sport, Health and Outdoor Education, Trinity Saint David, University of Wales, Wales, UK
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LD Hayes
LD Hayes
Active Ageing Research Group, Department of Medical and Sport Sciences, University of Cumbria, Lancaster, UK
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NF Sculthorpe
NF Sculthorpe
Institute of Clinical Exercise and Health Science, University of the West of Scotland, Scotland, UK
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FM Grace
FM Grace
Faculty of Health, Federation University, Victoria, Australia
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Introduction Peak muscle power is an important determinant of athletic performance across the lifespan that declines with age ( 1 ) and is accompanied by a precipitous decline in serum testosterone ( 2 ). Both present a noteworthy impediment
Mette Bøgehave
Mette Bøgehave
Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Dorte Glintborg
Dorte Glintborg
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
OPEN, Open Patient data Explorative Network, Odense University Hospital, Region of Southern Denmark, Odense, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
OPEN, Open Patient data Explorative Network, Odense University Hospital, Region of Southern Denmark, Odense, Denmark
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Jørgen Brodersen Gram
Jørgen Brodersen Gram
Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Else-Marie Bladbjerg
Else-Marie Bladbjerg
Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Marianne Skovsager Andersen
Marianne Skovsager Andersen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Johannes Jakobsen Sidelmann
Johannes Jakobsen Sidelmann
Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark
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Introduction Opioid medications are widely used to treat chronic non-cancer pain ( 1 ). Male hypogonadism, characterized by low concentrations of testosterone and luteinizing hormone (LH), is one of the most well-described hormonal adverse
