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Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, and John Nestler

Introduction Myo-inositol (MI) is one stereoisomer of a C 6 sugar alcohol that belongs to the inositol family ( 1 ). It is the precursor of inositol triphosphate, acting as an intracellular second messenger and regulating a number of hormones

Open access

Yiqiong Ma, Zhaowei Chen, Yu Tao, Jili Zhu, Hongxia Yang, Wei Liang, and Guohua Ding

M Victor VM . Mitochondrial dynamics in type 2 diabetes: pathophysiological implications . Redox Biology 2017 637 – 645 . ( ) 22 Sun L Dutta RK Xie P Kanwar YS . Myo-inositol oxygenase

Open access

Jia Li, Yan Zhao, Caoxin Huang, Zheng Chen, Xiulin Shi, Long Li, Zhong Chen, and Xuejun Li

altered endogenous metabolites, most belonged to sphingolipids (ceramide and its glycosides, glucosylsphingosine and ganglioside) and glycerophospholipids (phosphatidylethanolamine, PE; phosphatidylcholine, PC; mannosyl-inositol-phosphorylceramide, MIPC

Open access

Lei Lei, Yi-Hua Bai, Hong-Ying Jiang, Ting He, Meng Li, and Jia-Ping Wang

in the liver through the translocation and activation of the PI3K/Akt signaling pathway in T2D rats. They also found that D-chiro-inositol played a positive role in regulating insulin-mediated glucose uptake through the PI3K/Akt signaling pathway in T

Open access

Avinaash Maharaj, Ruth Kwong, Jack Williams, Christopher Smith, Helen Storr, Ruth Krone, Debora Braslavsky, Maria Clemente, Nanik Ram, Indraneel Banerjee, Semra Çetinkaya, Federica Buonocore, Tülay Güran, John C Achermann, Louise Metherell, and Rathi Prasad

sphingolipids, ceramide and sphingosine, on steroidogenesis. S1P exerts its effects through five G protein coupled receptors (S1PR 1-5 ), and its stimulation of downstream inositol triphosphate and calcium signalling can stimulate steroidogenesis ( 34 ). The

Open access

Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli, and A Di Baldassarre

. IP 3 -dependent Ca 2 + mobilization from intracellular stores. The binding of agonists (hormones and neurotransmitters) to the G-protein-coupled receptors determines the PIP 2 hydrolysis and the inositol trisphosphate (IP 3 ) generation. IP 3 binds

Open access

Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, and Songying Zhang

kinase (PERK), activating transcription factor-6 (ATF6), and inositol-requiring enzyme-1 (IRE1), the key regulators of UPR pathway, and found all of them were upregulated in PCOS mice compared to those in controls ( Fig. 1 ). XBP1 is the downstream

Open access

Zeeshan Javed, Maria Papageorgiou, Leigh A Madden, Alan S Rigby, Eric S Kilpatrick, Stephen L Atkin, and Thozhukat Sathyapalan

58 – 62 . ( ) 22 Morley LC Tang T Yasmin E Norman RJ Balen AH . Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome

Open access

Laura Potasso, Julie Refardt, Irina Chifu, Martin Fassnacht, Wiebke Kristin Fenske, and Mirjam Christ-Crain

osmolytes (e.g. glutamine and other aminoacids, glutamate, taurine, myo-inositol, etc.) are synthetized or shifted into ICF, and the previously internalized potassium is released back to extracellular fluid (ECF). As adaption to a chronic hyperosmolar state

Open access

Fernanda A Correa, Ericka B Trarbach, Cintia Tusset, Ana Claudia Latronico, Luciana R Montenegro, Luciani R Carvalho, Marcela M Franca, Aline P Otto, Everlayny F Costalonga, Vinicius N Brito, Ana Paula Abreu, Mirian Y Nishi, Alexander A L Jorge, Ivo J P Arnhold, Yisrael Sidis, Nelly Pitteloud, and Berenice B Mendonca

) . The p.Arg85Cys variant showed modest but a significant 30% reduction in maximal MAPK activation in an Egr1-Luc assay (26) . In inositol phosphatidyl (IP) accumulation assays, the variant showed similar dose–response curves to WT PROKR2. Also, the p