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Jie Shi, Zhen Yang, Yixin Niu, Weiwei Zhang, Ning Lin, Xiaoyong Li, Hongmei Zhang, Hongxia Gu, Jie Wen, Guang Ning, Li Qin, and Qing Su

Introduction Hypertension, characterized by chronically elevated blood pressure (BP) above 140/90 mmHg, is a major public health problem affecting more than 1 billion people worldwide ( 1 , 2 ). Despite multiple methods to prevent and manage

Open access

Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, and Manfredi Rizzo

fibrinogen, together with lower HDL-C levels ( 9 ). Insulin resistance and central adiposity are of crucial importance in the development of MetS, and they appear to correlate with cardiovascular (CV) risk factors, including hypertension, atherogenic

Open access

Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, and Atsuhiro Ichihara

Introduction Primary aldosteronism (PA) is defined as autonomous aldosterone production from the adrenal glands and represents the most common and treatable cause of hypertension. Patients with PA had a significantly higher risk of developing

Open access

Peng Fan, Chao-Xia Lu, Di Zhang, Kun-Qi Yang, Pei-Pei Lu, Ying Zhang, Xu Meng, Su-Fang Hao, Fang Luo, Ya-Xin Liu, Hui-Min Zhang, Lei Song, Jun Cai, Xue Zhang, and Xian-Liang Zhou

Introduction Over the past two decades, with advances in the understanding of genetic diseases of renal tubular transport defects, there has been greater interest in the importance of potassium in hypertension ( 1 ). Monogenic hypertension

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Jian Ding, Yan Kang, Yuqin Fan, and Qi Chen

-hypertensive drugs are commonly found to be of clinical efficacy in relieving hypertension ( 4 ). Nifedipine (NIFE) is among several first-line anti-hypertensive treatments among PE patients ( 3 , 5 , 6 ). NIFE is a Ca 2+ channel inhibitor ( 5 ) and functions to

Open access

Maria Lola Evia-Viscarra, Edel Rafael Rodea-Montero, Evelia Apolinar-Jiménez, and Silvia Quintana-Vargas

, respiratory, metabolic (hyperglycemia, dyslipidemia), hepatic (non-alcoholic fatty liver disease), and cardiovascular disease (CVD) (arterial hypertension and vascular dysfunction). The chronic evolution of obesity generates devastating consequences that are

Open access

N Bergmann, F Gyntelberg, and J Faber

Introduction The metabolic syndrome (MES) is a cluster of risk factors including male adiposity, dyslipidemia, reduced glucose tolerance and hypertension. MES is highly prevalent and increasing in most parts of the world (1) . A meta-analysis has

Open access

Ling-Jun Li, Izzuddin M Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan, and Jie Jin Wang

–63% developed T2D within 5–16 years ( 11 , 12 ), and 10% developed renal disease within 11 years after delivery ( 13 ). Interestingly, HDP including gestational hypertension, preeclampsia (PE) and eclampsia is more frequent among GDM mothers ( 14 , 15

Open access

Lasse Oinonen, Antti Tikkakoski, Jenni Koskela, Arttu Eräranta, Mika Kähönen, Onni Niemelä, Jukka Mustonen, and Ilkka Pörsti

Introduction A great majority of hypertensive subjects (~90%) have primary hypertension with an undefined aetiology ( 1 ). Circulating parathyroid hormone (PTH) concentration has been associated with blood pressure (BP) ( 2 , 3 , 4 ) and

Open access

Jan Roar Mellembakken, Azita Mahmoudan, Lars Mørkrid, Inger Sundström-Poromaa, Laure Morin-Papunen, Juha S Tapanainen, Terhi T Piltonen, Angelica Lindén Hirschberg, Elisabet Stener-Victorin, Eszter Vanky, Pernille Ravn, Richard Christian Jensen, Marianne Skovsager Andersen, and Dorte Glintborg

PCOS have BP > 130/85 mmHg ( 4 ) and also young women with PCOS have around three times increased risk of hypertension (HT) compared to controls ( 3 , 5 , 6 , 7 ). In accordance, the recent international PCOS guideline recommends that BP should be