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C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby, and M D Robertson

period, participants completed a 7-day food and drink diary and a 7-day bowel habit and symptom diary. Participants attended for three study visits at the end of each intervention: i) a two-step euglycemic–hyperinsulinemic clamp combined with an infusion

Open access

Xingrong Tan, Wenjing Hu, Shan Yang, Han Dai, Shangcheng Xu, Gangyi Yang, Ling Li, Shiguo Tang, and Yi Wang

impact of high insulin levels on circulating ZAG, irisin, and betatrophin concentrations by the euglycemic–hyperinsulinemic clamp (EHC). We also compared the characteristics of each MetS component in the study population. Materials and methods

Open access

Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila, and Heikki A Koistinen

employed the euglycemic hyperinsulinemic clamp technique (29) to study whether insulin affects markers of bone remodeling, particularly OC, in humans. A few studies have applied this technique to assess acute insulin-driven changes in bone metabolism (30

Open access

Taísa A R Vicente, Ívina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari, and Manuel H Aguiar-Oliveira

measurement has an excellent correlation with the euglycemic–hyperinsulinemic clamp (24) , the ‘gold standard’ method to assess IS, used in acquired AOGHD (25) . The increase of IS in the IGHD group may be caused by the marked reduction in GH levels and

Open access

Antonia Ertelt, Ann-Kristin Barton, Robert R Schmitz, and Heidrun Gehlen

proliferation and tissue growth and repair, might be another key in the pathogenesis of laminitis (126) . Gene expression for IGF1 receptor (IGF1R) and insulin receptor were decreased by 13- to 32-fold during a prolonged euglycemic, hyperinsulinemic clamp test

Open access

Alessandra Gambineri and Carla Pelusi

-to-male transsexuals demonstrated that testosterone-ester administration at the dose of 250 mg i.m. every 2 weeks produced a significant increase in visceral adipose tissue and a decrease in insulin sensitivity evaluated by the euglycemic–hyperinsulinemic clamp ( 19

Open access

Julia Otten, Andreas Stomby, Maria Waling, Elin Chorell, Mats Ryberg, Michael Svensson, Jens Juul Holst, and Tommy Olsson

. Fasting glucagon levels at baseline were associated with body weight (r S  = 0.56, P < 0.01) and with hepatic insulin sensitivity, measured as suppression of endogenous glucose production during the euglycemic-hyperinsulinemic clamp, normalized by

Open access

Signe Frøssing, Malin Nylander, Caroline Kistorp, Sven O Skouby, and Jens Faber

between MR-proADM levels and BMI or VAT, both at baseline and after weight reduction. With respect to insulin resistance, previous studies are conflicting. During a euglycemic hyperinsulinemic clamp in obese individuals, plasma ADM increased in response

Open access

Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, John Vissing, Morten Frost, Knud Bonnet Yderstræde, and Per Heden Andersen

been shown to be inversely correlated with glucose uptake in the left ventricle of the heart during an euglycemic hyperinsulinemic clamp in m.3243A>G carriers ( 39 ). Furthermore, glycolysis and insulin signaling are suppressed in red fibers of

Open access

Lars Peter Sørensen, Tina Parkner, Esben Søndergaard, Bo Martin Bibby, Holger Jon Møller, and Søren Nielsen

euglycemic hyperinsulinemic clamp technique (26) , which was evident in normal-weight and obese healthy individuals (20, 21, 26) , as well as in individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM (24