Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK
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mortality ( 2 ). Replacement with glucocorticoid therapy is the mainstay of treatment, with an objective to mimic the circadian cortisol profile ( 3 ). Current guidelines recommend the use of hydrocortisone in divided doses or low-dose (3–5 mg
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Division of Medicine, Akershus University Hospital, Lørenskog, Norway
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Department of Clinical Medicine, University of Bergen, Bergen, Norway
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K.G. Jebsen-Center for Autoimmune Diseases, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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K.G. Jebsen-Center for Autoimmune Diseases, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Introduction Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders with impaired biosynthesis of adrenal glucocorticosteroids and defects in cortisol biosynthesis. More than 95% of cases are caused by mutations in
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Imperial College Healthcare NHS Trust, London, UK
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Imperial College Healthcare NHS Trust, London, UK
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Imperial College Healthcare NHS Trust, London, UK
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Imperial College Healthcare NHS Trust, London, UK
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Imperial College Healthcare NHS Trust, London, UK
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(persistent hiccup). One patient was hypotensive (systolic BP <90 mmHg; serum cortisol of 118 nmol/L and serum sodium of 115 nmol/L on admission). However, 11/30 were hypertensive at presentation (systolic BP >140 mmHg) ( Table 2 ). Symptoms consistent with
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Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic
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Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic
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-hydroxysteroid dehydrogenase type 1 (11HSD1) and type 2 (11HSD2). 11HSD2 is an enzyme that catalyzes the oxidations of cortisol and corticosterone to the inactive cortisone and 11-dehydrocorticosterone, reducing the local glucocorticoid signals. In contrast, 11HSD1 converts
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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monitoring of prednisone and prednisolone has the potential to optimize treatment (11, 12) . Because of the widespread use of these glucocorticoids and impact on endogenous cortisol levels, information on serum levels may also be valuable in the setting of a
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actually represent a drive to lower cortisol, with its sequelae? Or is the heightened secretion of corticosteroids in drug withdrawal simply a response to stress? We here argue that the adrenal cortex has a critical role in the acquisition of addiction and
Université Lyon 1, Villeurbanne, France
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Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Université Lyon 1, Villeurbanne, France
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INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
Service de Neurochirurgie, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
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Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Introduction Cushing’s disease is a rare disorder defined as chronic hypercortisolism due to a corticotropin-secreting pituitary tumor (corticotroph tumor) ( 1 ). Chronic cortisol excess is responsible for multisystem morbidity, contributing
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endocrinology residents from the 12 Portuguese centres. AD was diagnosed based on one of the following criteria: (1) a plasma adrenocorticotropic hormone (ACTH) concentration exceeding 66 pmol/L in combination with a low serum cortisol (<5 µg/dL); (2) an
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analysis Blood samples were stored at −20°C and analysed in the same assay after all participants had completed all trials. Serum concentrations of cortisol (ELISA, DRG Cortisol Enzyme Immunoassay Kit, Germany), glucagon (EMD Millipore’s Glucagon
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Department of Endocrinology, Mediclinic Airport Road Hospital, Abu Dhabi, United Arab Emirates
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in addition to serum sodium and serum potassium only, clinical features and serum sodium and/or serum potassium in addition to relevant antibodies, or clinical features in addition to low serum cortisol with synthetic ACTH (tetracosactide) stimulation