Bruno Donadille
Bruno Donadille
Service d’Endocrinologie et Médecine de la Reproduction, Centre de Référence des Maladies Endocrines Rares de la Croissance, Hôpital Saint Antoine, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France
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Muriel Houang
Muriel Houang
Service d’Explorations Fonctionnelles Endocriniennes, Centre de Référence des Maladies Endocrines Rares de la Croissance, Hôpital Trousseau, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France
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Irène Netchine
Irène Netchine
Service d’Explorations Fonctionnelles Endocriniennes, Centre de Référence des Maladies Endocrines Rares de la Croissance, Hôpital Trousseau, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France
Université Pierre et Marie Curie, Sorbonne Université, Paris, France
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
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Jean-Pierre Siffroi
Jean-Pierre Siffroi
Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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INSERM UMR_S933, Paris, France
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Sophie Christin-Maitre
Sophie Christin-Maitre
Service d’Endocrinologie et Médecine de la Reproduction, Centre de Référence des Maladies Endocrines Rares de la Croissance, Hôpital Saint Antoine, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France
Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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severe form of HSD3B2 mutation, male patients present neonatal salt wasting, as well as disorders of sexual development (DSD), with micropenis and severe hypospadias. The external genitalia morphogenesis is impaired due to the diminished testosterone
T P Parikh
T P Parikh
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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B Stolze
B Stolze
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
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Y Ozarda
Y Ozarda
Department of Medical Biochemistry, Faculty of Medicine, Uludag University, Bursa, Turkey
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J Jonklaas
J Jonklaas
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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K Welsh
K Welsh
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
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L Masika
L Masika
Department of Laboratory Medicine and Pathology/National Health Laboratory Service Walter Sisulu University, Mthatha, South Africa
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M Hill
M Hill
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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A DeCherney
A DeCherney
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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S J Soldin
S J Soldin
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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Introduction Diurnal variations in the serum concentration of steroid hormones and their metabolism, as assessed by urinary excretion, have long been known for cortisol and testosterone ( 1 , 2 , 3 ). Less information exists for the other up
Sakina Kherra
Sakina Kherra
CHU Parnet Hopital, Algiers, Algeria
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Wendy Forsyth Paterson
Wendy Forsyth Paterson
Royal Hospital for Sick Children, Yorkhill, Glasgow, UK
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Filiz Mine Cizmecioglu
Filiz Mine Cizmecioglu
Paediatric Endocrinology and Diabetes Department, Kocaeli University, Kocaeli, Turkey
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Jeremy Huw Jones
Jeremy Huw Jones
Department of Pediatric Endocrinology, Royal Hospital for Children Glasgow, NHS Greater Glasgow and Clyde, Glasgow, UK
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Mariam Kourime
Mariam Kourime
Abderrahim Harouchi Hôpital, Casablanca, Morocco
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Heba Hassan Elsedfy
Heba Hassan Elsedfy
Pediatrics Department, Ain Shams University, Cairo, Egypt
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Sameh Tawfik
Sameh Tawfik
Department of Pediatrics, Maadi Hospital, Cairo, Egypt
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Andreas Kyriakou
Andreas Kyriakou
Department of Pediatric Endocrinology, Royal Hospital for Children Glasgow, NHS Greater Glasgow and Clyde, Glasgow, UK
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Mohamad Guftar Shaikh
Mohamad Guftar Shaikh
Department of Pediatric Endocrinology, Royal Hospital for Children Glasgow, NHS Greater Glasgow and Clyde, Glasgow, UK
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Malcolm David Cairns Donaldson
Malcolm David Cairns Donaldson
Section of Child Health, Glasgow University School of Medicine, Glasgow, UK
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). Clinical features include small penis, scrotal hypoplasia and cryptorchidism at birth, with spontaneous puberty but mid-pubertal arrest and reduced testicular volume attributable to a reduction in seminiferous tubules. Basal gonadotrophins and testosterone
Bo Zhu
Bo Zhu
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Yumei Chen
Yumei Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Fang Xu
Fang Xu
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xiaolu Shen
Xiaolu Shen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xuanyu Chen
Xuanyu Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Jieqiang Lv
Jieqiang Lv
Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Songying Zhang
Songying Zhang
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
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in islets of the well-established dehydroepiandrosterone (DHEA)-induced PCOS animal model and revealed the effects of testosterone (TE) on ER stress and apoptosis in both INS-1 cells and primary cultured mouse islets. Finally, we demonstrated that TE
Ladan Younesi
Ladan Younesi
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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Zeinab Safarpour Lima
Zeinab Safarpour Lima
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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Azadeh Akbari Sene
Azadeh Akbari Sene
Department of Obstetrics and Gynecology, IVF Fellowship, Shahid Akbar-Abadi Hospital IVF Center, Iran University of Medical Sciences, Tehran, Iran
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Zahra Hosseini Jebelli
Zahra Hosseini Jebelli
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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Ghazaleh Amjad
Ghazaleh Amjad
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
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ultrasonography (TVU) was performed in early follicular phase (between two and five cycles), and then the patients were tested for serum levels of luteinizing hormones, FSH, prolactin (PRL), estradiol, free testosterone, 17α-hydroxyprogesterone (17-OHP) and DHEAS
Angela Köninger
Angela Köninger
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Philippos Edimiris
Philippos Edimiris
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Laura Koch
Laura Koch
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Antje Enekwe
Antje Enekwe
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Claudia Lamina
Claudia Lamina
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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Sabine Kasimir-Bauer
Sabine Kasimir-Bauer
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Rainer Kimmig
Rainer Kimmig
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Hans Dieplinger
Hans Dieplinger
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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amenorrhea, defined as cycles lasting longer than 3 months), clinical or biochemical signs of hyperandrogenism (hirsutism) with a Ferriman–Gallwey score of more than seven (17) or obvious acne or alopecia (18) or an elevated total testosterone (normal
Shenglong Le
Shenglong Le
Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Leiting Xu
Leiting Xu
Medical School, Ningbo University, Ningbo, China
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Moritz Schumann
Moritz Schumann
Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany
The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
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The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
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Na Wu
Na Wu
Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Timo Törmäkangas
Timo Törmäkangas
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Markku Alén
Markku Alén
Department of Medical Rehabilitation, Oulu University Hospital, Oulu, Finland
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Sulin Cheng
Sulin Cheng
Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
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Petri Wiklund
Petri Wiklund
Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Department of Epidemiology and Biostatistics, Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Department of Epidemiology and Biostatistics, Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
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centrifugation and stored immediately at −80°C until analysis. The samples from different time points were analyzed by one technician using the same kits and instrument. Estradiol (E2), testosterone and SHBG were determined by ELISA (NovaTec Immunodiagnostica
Jana Ernst
Jana Ernst
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Katharina Gert
Katharina Gert
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Frank Bernhard Kraus
Frank Bernhard Kraus
Central Laboratory, University Hospital Halle (Saale), Ernst-Grube-Strasse, Halle (Saale), Germany
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Ulrike Elisabeth Rolle-Kampczyk
Ulrike Elisabeth Rolle-Kampczyk
Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany
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Martin Wabitsch
Martin Wabitsch
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
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Faramarz Dehghani
Faramarz Dehghani
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Kristina Schaedlich
Kristina Schaedlich
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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well as the active androgen testosterone, being the most abundant in the circulation ( 9 ). However, it has also been hypothesized that a further and substantial contributor to androgen production is adipose tissue ( 10 ). Besides the body’s own
Xingyan Liu
Xingyan Liu
Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China
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Mei Xu
Mei Xu
Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China
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Min Qian
Min Qian
Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China
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Lindong Yang
Lindong Yang
Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China
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genotype) and outcome measurement data (serum testosterone levels in total and different genotype, BMI). Furthermore, the Hardy–Weinberg equilibrium (HWE) test was also calculated manually. The characteristics of studies are summarized in Table 1
Signe Frøssing
Signe Frøssing
Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Malin Nylander
Malin Nylander
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Caroline Kistorp
Caroline Kistorp
Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Sven O Skouby
Sven O Skouby
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Jens Faber
Jens Faber
Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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testosterone was analyzed with mass spectroscopy (Waters UPLC-TQS LC–MS/MS system, Milford, USA), inter-assay CV 10%. Free testosterone was calculated from total testosterone and sex hormone binding globulin (SHBG). SHBG was analyzed with a sandwich
