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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
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INSERM UMR_S933, Paris, France
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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severe form of HSD3B2 mutation, male patients present neonatal salt wasting, as well as disorders of sexual development (DSD), with micropenis and severe hypospadias. The external genitalia morphogenesis is impaired due to the diminished testosterone
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Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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Introduction Diurnal variations in the serum concentration of steroid hormones and their metabolism, as assessed by urinary excretion, have long been known for cortisol and testosterone ( 1 , 2 , 3 ). Less information exists for the other up
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). Clinical features include small penis, scrotal hypoplasia and cryptorchidism at birth, with spontaneous puberty but mid-pubertal arrest and reduced testicular volume attributable to a reduction in seminiferous tubules. Basal gonadotrophins and testosterone
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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in islets of the well-established dehydroepiandrosterone (DHEA)-induced PCOS animal model and revealed the effects of testosterone (TE) on ER stress and apoptosis in both INS-1 cells and primary cultured mouse islets. Finally, we demonstrated that TE
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ultrasonography (TVU) was performed in early follicular phase (between two and five cycles), and then the patients were tested for serum levels of luteinizing hormones, FSH, prolactin (PRL), estradiol, free testosterone, 17α-hydroxyprogesterone (17-OHP) and DHEAS
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Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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amenorrhea, defined as cycles lasting longer than 3 months), clinical or biochemical signs of hyperandrogenism (hirsutism) with a Ferriman–Gallwey score of more than seven (17) or obvious acne or alopecia (18) or an elevated total testosterone (normal
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
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Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Department of Epidemiology and Biostatistics, Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
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centrifugation and stored immediately at −80°C until analysis. The samples from different time points were analyzed by one technician using the same kits and instrument. Estradiol (E2), testosterone and SHBG were determined by ELISA (NovaTec Immunodiagnostica
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well as the active androgen testosterone, being the most abundant in the circulation ( 9 ). However, it has also been hypothesized that a further and substantial contributor to androgen production is adipose tissue ( 10 ). Besides the body’s own
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genotype) and outcome measurement data (serum testosterone levels in total and different genotype, BMI). Furthermore, the Hardy–Weinberg equilibrium (HWE) test was also calculated manually. The characteristics of studies are summarized in Table 1
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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testosterone was analyzed with mass spectroscopy (Waters UPLC-TQS LC–MS/MS system, Milford, USA), inter-assay CV 10%. Free testosterone was calculated from total testosterone and sex hormone binding globulin (SHBG). SHBG was analyzed with a sandwich