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Ram P Narayanan, Bo Fu, Adrian H Heald, Kirk W Siddals, Robert L Oliver, Julie E Hudson, Antony Payton, Simon G Anderson, Anne White, William E R Ollier, and J Martin Gibson

functional homology with insulin. They are ubiquitously expressed and play an indispensible role in the control of growth, proliferation and metabolism. IGF1 and IGF2 effect local and systemic responses through autocrine, paracrine and endocrine mechanisms

Open access

Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ, and Albert Beckers

Introduction Acromegaly is a rare, classical endocrine disorder that is due to chronic excess secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) that has a prevalence of 1 in 8000–14,000 of the population ( 1 , 2 , 3

Open access

Ruth Therese Casey, Deborah Saunders, Benjamin George Challis, Deborah Pitfield, Heok Cheow, Ashley Shaw, and Helen Lisa Simpson

Introduction Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine neoplasia syndrome characterised by autosomal dominant inheritance of mutations in MENIN , a tumour suppressor gene. Patients with MEN1 typically develop

Open access

Eliana Piantanida, Daniela Gallo, Giovanni Veronesi, Eugenia Dozio, Eugenia Trotti, Adriana Lai, Silvia Ippolito, Jessica Sabatino, Maria Laura Tanda, Antonio Toniolo, Marco Ferrario, and Luigi Bartalena

for metabolic disorders. Materials and methods Subjects Consecutive Caucasian obese adults with visceral obesity attending the Obesity Outpatient Clinic of the Endocrine Unite at the University of Insubria were enrolled during the years

Open access

A C Paepegaey, M Coupaye, A Jaziri, F Ménesguen, B Dubern, M Polak, J M Oppert, M Tauber, G Pinto, and C Poitou

Introduction Prader–Willi syndrome (PWS) is a complex developmental genetic disorder including obesity with hyperphagia, psychiatric disturbances, endocrine and metabolic disorders ( 1 , 2 ). Global incidence has been recently evaluated as 1

Open access

Ekaterina Koledova, George Stoyanov, Leroy Ovbude, and Peter S W Davies

diagnoses and treatment decisions were at the discretion of the investigating physician, following standard endocrine practice. The study was conducted in accordance with the principles of the Declaration of Helsinki, Good Clinical Practice (ICH-GCP E6

Open access

K E Lines, R P Vas Nunes, M Frost, C J Yates, M Stevenson, and R V Thakker

Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder, characterised by the combined occurrence of tumours of the parathyroid glands, and neuroendocrine tumours (NETs) of the pancreatic islets and anterior

Open access

M Axelstad, U Hass, M Scholze, S Christiansen, A Kortenkamp, and J Boberg

certain endocrine-disrupting chemicals (EDCs). Numerous EDCs are present in our environment, and EDCs are suspected of playing a role in testicular dysgenesis syndrome (TDS) in humans. This syndrome encompasses a range of male disorders, presumed to have

Open access

Thabiso R P Mofokeng, Salem A Beshyah, Fazleh Mahomed, Kwazi C Z Ndlovu, and Ian L Ross

survey, manage patients with hypoadrenalism (Supplementary Appendix 1). The respondents were mostly non-endocrine specialists (48.8%) and primary care doctors (33.3%) and the minority (17.6%) were specialist endocrinologists. The proportion who identified

Open access

Weixi Wang, Rulai Han, Lei Ye, Jing Xie, Bei Tao, Fukang Sun, Ran Zhuo, Xi Chen, Xiaxing Deng, Cong Ye, Hongyan Zhao, and Shu Wang

Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease characterized by the presence of endocrine tumors mainly affecting parathyroid, pituitary and pancreatic islet. Adrenal lesions occur in 20–55% of MEN1