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Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Introduction Testosterone plays a key role in the regulation of glucose and lipid metabolism in men ( 1 ) and women ( 2 ) although in different manners. Low concentrations of testosterone in men are associated with obesity ( 3 ), the metabolic
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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is testosterone. However, literature regarding the effects of testosterone on the kidney has shown conflicting results. On the one hand, it is suggested that testosterone has harmful effects on the kidney, such as glomerular and tubular damage, kidney
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Introduction Low testosterone as well as high C-reactive protein (CRP) levels have been associated with increased risk for all-cause mortality in men ( 1 , 2 , 3 , 4 ). Testosterone concentration decreases with aging, and if reaching
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), hormonal evaluation (follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone), imaging details (transabdominal sonography, computed tomography/magnetic resonance imaging), surgical details and follow-up of the patients were collected
Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
National Institute for Health Research (NIHR) Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK
Mohn Centre for Children’s Health and Wellbeing, Imperial College London, London, UK
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
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NIHR Health Protection Research Unit on Chemical Radiation Threats and Hazards, Imperial College London, London, UK
National Institute for Health Research (NIHR) Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK
Mohn Centre for Children’s Health and Wellbeing, Imperial College London, London, UK
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Introduction Pubertal progress is accompanied by a steady increase in a wide range of sex steroids that are produced by the adrenal glands and the gonads. The increase of serum testosterone and free testosterone during puberty is well
Department of Pediatrics, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil
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Department of Pediatrics, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
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Poison Control Center, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
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Laboratory of Human Molecular Genetics, Center for Molecular Biology and Genetics Engineering (CBMEG), UNICAMP, Campinas, Sao Paulo, Brazil
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Department of Medical Genetics and Genomic Medicine, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
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Department of Pediatrics, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
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with DSD ( 2 ). One of the most important challenge is the measurement of testosterone concentration ( 9 , 10 ), especially in the investigation of 46,XY DSD cases. DSD are congenital conditions in which chromosomal, gonadal or anatomical sex is
Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Internal Medicine, Lillebaelt Hospital, Kolding, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
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Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
Department of Haematology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
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demonstrated in non-KS obese men with hypogonadism ( 14 ) and data from several studies have demonstrated an array of effects of androgenic compounds on fibrinolytic markers, collectively suggesting that normal plasma testosterone actively supports fibrinolysis
Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
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Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, New South Wales, Australia
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Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
School of Medicine, UNSW Sydney, Sydney, New South Wales, Australia
Translational Health Research Institute, Penrith, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
School of Medicine, UNSW Sydney, Sydney, New South Wales, Australia
Translational Health Research Institute, Penrith, New South Wales, Australia
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Introduction Sarcopenia, the age-related loss of muscle mass and function, presents an escalating public health burden, contributing to increased falls, disability and loss of functional independence ( 1 ). In men, testosterone is critical for
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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hyperandrogenism (5, 6) . They are commonly associated with high testosterone levels (7, 8) . High plasma levels of testosterone associated with normal dehydroepiandrosterone sulfate (DHEAS) concentration are indicative of ovarian hyperthecosis or androgen
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Department of Medicine, University of Padova, Padova, Italy
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later in life. Testosterone and bone health in subjects with KS Testosterone is clearly the major testicular factor influencing bone metabolism ( 1 ), having a direct effect on osteoclasts, osteoblasts, and osteocytes and promoting periosteal