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Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani and John Nestler

( 24 , 25 , 26 , 27 ), psychological distress ( 28 ) and ostensibly mood disorders ( 29 , 30 ). A meta-analysis also reported the association between women with PCOS and cancer of the endometrium and ovarian cancer ( 31 ). It is noteworthy that

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

sitagliptin increased post-meal GLP-1 levels, it did not change HbA1c, body weight or the rate of hypoglycaemia progression ( 19 ). Due to the conflicting results, we collected all the available data and conducted a meta-analysis to robustly evaluate the

Open access

Nafiye Helvaci, Erdem Karabulut, Ahmet Ugur Demir and Bulent Okan Yildiz

fully understood, obesity, insulin resistance and hyperandrogenemia, which are the main features of PCOS, are all proposed to play a role in the development of OSA in patients with PCOS. The objective of this meta-analysis was to examine if there is an

Open access

Isabel M Abreu, Eva Lau, Bernardo de Sousa Pinto and Davide Carvalho

subclinic* and (cardiovascular* or cardiac* or dyslipidem*) and (treat* or manage* or levothyroxine). We followed the PRISMA checklist for meta-analysis. The search was restricted to the English language, human species and randomized control trials

Open access

Liza Haqq, James McFarlane, Gudrun Dieberg and Neil Smart

different inclusion/exclusion criteria. However, our work provides a greater number of hormonal analyses when compared with Moran's work (14) . We therefore conducted a systematic review and meta-analysis, and the primary aim was to evaluate the expected

Open access

D Santi, A R M Granata and M Simoni

overall effect of FSH treatment of the man in couples attending ART enrolled in randomised, controlled, clinical trials (15) . This meta-analysis demonstrates that FSH treatment significantly improves spontaneous pregnancy rate, whereas no improvement of

Open access

Zhou-Qing Kang, Jia-Ling Huo and Xiao-Jie Zhai

with 95% CIs. Due to the potential heterogeneity (surgery type, intervention time, blood glucose target, follow-up time, etc.) that existed among the included studies, the meta-analysis was performed with a random effects model. We used I 2 test to

Open access

Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

performed a comprehensive systematic review and meta-analysis of observational studies to examine the prognostic impact of molecular markers on tumor recurrence and cancer-related mortality in PTC. Materials and methods Literature search Four

Open access

Sarah Byberg, Jesper Futtrup, Mikkel Andreassen and Jesper Krogh

the metabolic effects of dopamine agonist treatment in patients with prolactinomas. Methods Study design A systematic review and meta-analysis. The study was registered with PROSPERO (registration number CRD42016046525). Study

Open access

Wei Sun, Boyuan Zheng, Zhihong Wang, Wenwu Dong, Yuan Qin and Hao Zhang

Background: Papillary thyroid cancer (PTC) patients with clinical negative central lymph nodes (cN0), the use of prophylactic central lymph node dissection remains controversial. Patients with cN0 disease receive contralateral central lymph node metastasis (CCLNM) 3.88–30.63% of cases. Therefore, the present study aimed to obtain evidence for CCLNM risk factors in unilateral cN0 PTC.

Materials and methods: Relevant studies were searched in the PubMed, SCIE, and Wanfang databases up to 31 Oct 2019. The included patients had undergone lobectomy or total thyroidectomy with bilateral central lymph node dissection and were diagnosed pathologically with PTC.

Results: Thirteen studies comprising 2449 patients were included. The factors associated with increased CCLNM risk in cN0 unilateral PTC were: age < 45 years (odds ratio (OR) = 1.89, 95% confidence interval (CI) = 1.43–2.49, P < 0.00001), male sex (OR = 1.67, 95% CI = 1.24–2.24, P = 0.0007), extrathyroidal extension (OR = 1.63; 95% CI = 1.17-2.28; P = 0.004), tumor size ≥ 1 cm (OR = 2.63, 95% CI 1.85–3.74, P < 0.00001), lymphovascular invasion (OR = 4.27, 95% CI =2.47-7.37, P < 0.00001) and ipsilateral CLNM (OR = 11.42, 95% CI = 5.25-24.86, P < 0.00001). However, no association was found for capsular invasion, multifocality and Hashimoto thyroiditis.

Conclusion: The study identified that age <45 years, tumor ≥1 cm, male sex, lymphovascular invasion, extrathyroidal extension and ipsilateral CLNM are related to CCLNM in CN0 PTC. These factors should influence the use of prophylactic central lymph node dissection in these patients.