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Qing Zhou Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China

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Li Yong Zhang Department of Thyroid Surgery, Minimal Invasive Center, Fujian Medical University Union Hospital, Fuzhou, China

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Mei Feng Dai Department of Clinical Lab, Fujian Maternity and Child Health Hospital, Fuzhou, China

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Zhen Li Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China

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Chao Chun Zou Department of Endocrinology, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

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Hui Liu Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China

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), and inositol-requiring protein enzyme (IRE)-1, which were similar to the increase in response to TM, an ER stress agonist. Moreover, in the current study, the addition of the ER stress inhibitor 4-PBA blocked the expression of PERK, ATF6, and IRE1

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Kjell Oberg Uppsala University, Uppsala, Sweden

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Eric Krenning Erasmus Medical Center, Rotterdam, Netherlands

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Anders Sundin Uppsala University, Uppsala, Sweden

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Lisa Bodei Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Margot Tesselaar Netherlands Cancer Institute, Amsterdam, Netherlands

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Valentina Ambrosini University of Bologna, Bologna, Italy

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Richard P Baum Zentralklinik Bad Berka, Bad Berka, Germany

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Matthew Kulke Dana Farber Cancer Institute, Boston, Massachusetts, USA

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Marianne Pavel Charite Hospital, Berlin, Germany

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Jaroslaw Cwikla University of Warmia and Mazury, Olsztyn, Poland

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Ignat Drozdov Wren Laboratories, Branford, Connecticut, USA

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Massimo Falconi Ospedale San Raffaele, Milan, Italy

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Nicola Fazio IEO (European Institute of Oncology), Milan, Italy

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Andrea Frilling Imperial College London, London, UK

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Robert Jensen National Institutes of Health, Bethesda, Maryland, USA

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Klaus Koopmans Martini Ziekenhuis, Groningen, Netherlands

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Tiny Korse Netherlands Cancer Institute, Amsterdam, Netherlands

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Dik Kwekkeboom Erasmus Medical Center, Rotterdam, Netherlands

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Helmut Maecke University Hospital Freiburg, Freiburg, Germany

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Giovanni Paganelli Instituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy

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Ramon Salazar Instituto Catala d’Oncologia, Barcelona, Spain

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Stefano Severi Instituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy

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Jonathan Strosberg H. Lee Moffitt Cancer Center, Tampa, Florida, USA

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Vikas Prasad Charite Hospital, Berlin, Germany

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Aldo Scarpa University of Verona, Verona, Italy

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Ashley Grossman Univeristy of Oxford, Oxford, UK

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Annemeik Walenkamp University of Groningen, Groningen, Netherlands

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Mauro Cives H. Lee Moffitt Cancer Center, Tampa, Florida, USA

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Irene Virgolini Medical University Innsbruck, Innsbruck, Austria

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Andreas Kjaer Copenhagen University, Copenhagen, Denmark

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Irvin M Modlin Yale University, New Haven, Connecticut, USA

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) 81 Sei Y Zhao X Forbes J Szymczak S Li Q Trivedi A Voellinger M Joy G Feng J Whatley M A hereditary form of small intestinal carcinoid associated with a germline mutation in inositol polyphosphate multikinase

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Tatsuya Kondo Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan

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Nobukazu Miyakawa Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Sayaka Kitano Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan

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Takuro Watanabe Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Rieko Goto Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Mary Ann Suico Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Miki Sato Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Yuki Takaki Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Masaji Sakaguchi Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Motoyuki Igata Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan

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Junji Kawashima Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Hiroyuki Motoshima Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Takeshi Matsumura Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Hirofumi Kai Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Eiichi Araki Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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of the inositol-requiring enzyme 1–X-box-binding protein-1 pathway ( 42 ). In addition, modulations of the HSP pathway have been shown to suppress canonical TGF-β and NF-κB signaling. HSP72 blocks NF-κB activation at multiple aspects, such as by

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Davoud Jafari-Gharabaghlou Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Mostafa Vaghari-Tabari Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Hajar Oghbaei Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran

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Laura Lotz Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany

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Reza Zarezadeh Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Yeganeh Rastgar Rezaei Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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Mahnaz Ranjkesh Medical Radiation Science Research Group (MRSRG), Tabriz University of Medical Sciences, Tabriz, Iran

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Mohammad Nouri Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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Amir Fattahi Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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Saba Nikanfar Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Ralf Dittrich Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany

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, progesterone; PCNA, proliferating cell nuclear antigen; PI3K/AKT, phosphatidyl inositol-3-kinase/ protein kinase B; StAR, steroidogenic acute regulatory protein; STAT3, signal transducer and activator of transcription 3; TNF, tumor necrosis factor; uPA

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Sandra Pereira Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Jessy Moore Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

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Jia-Xu Li Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada

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Wen Qin Yu Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Husam Ghanim Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA

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Filip Vlavcheski Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

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Yemisi Deborah Joseph Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Paresh Dandona Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA

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Allen Volchuk Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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Carolyn L Cummins Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada

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Evangelia Tsiani Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

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Adria Giacca Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

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protein content was similar between groups ( Fig. 3C ). However, in adipose tissue, IH infusion augmented p-eIF2α protein levels and this was prevented by PBA ( P < 0.05, Fig. 4A ). Inositol requiring 1α (IRE1α) showed a similar profile to p-eIF2α

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Mojca Jensterle Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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Nika Aleksandra Kravos Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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Simona Ferjan Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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Katja Goricar University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia

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Vita Dolzan University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia

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Andrej Janez Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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(metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility . Cochrane Database of Systematic Reviews 2012 CD003053 . ( https://doi.org/10.1002/14651858.CD003053.pub5 ) 16

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Cleofas Marcial-Medina Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Alejandra Ordoñez-Moreno Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Christian Gonzalez-Reyes Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Pedro Cortes-Reynosa Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Eduardo Perez Salazar Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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30 193 – 204 . ( https://doi.org/10.1016/j.ctrv.2003.07.007 ) 10.1016/j.ctrv.2003.07.007 15023437 21 Dillon RL White DE Muller WJ. The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer . Oncogene 2007 26

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Karim Gariani Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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://doi.org/10.1074/jbc.M111.228817 ) 51 Jurczak MJ Lee AH Jornayvaz FR Lee HY Birkenfeld AL Guigni BA Kahn M Samuel VT Glimcher LH Shulman GI Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation

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Wenrui Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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Chuan Zhang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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( 59 ). Combinatorial signals from the three core components of the UPR (protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)) initially trigger transcriptional

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Qian Deng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Yue Zhu Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Mengmeng Zhang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Aihua Fei Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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Jiaqi Liang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Jinjin Zheng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Qingping Zhang College of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China

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Tong Cheng Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China

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Xia Ge Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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. ( https://doi.org/10.1089/ars.2016.6665 ) 35 Deng F Sharma I Dai Y Yang M Kanwar YS . myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule . Journal of Clinical Investigation 2019 129 5033

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