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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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resection extent). Laboratory variables included preoperative serum sodium, cortisol, thyroxine, and free thyroxine. To avoid bias during data entry, investigators were blinded to the predictors and outcome using natural language processing and an automatic
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group, according to the results of the adrenal venous sampling (AVS). The adrenal venous blood aldosterone-to-cortisol ratio after cosyntropin stimulation was calculated bilaterally. In AVS, selectivity index (SI), lateralized ratio (LR), and
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) that is predominantly occupied by cortisol in human plasma ( 4 ). Human CBG is also known as SERPINA6 and shares structural similarity with several SERPINA family members ( 5 ) that inhibit specific proteases by ensnaring them after proteolysis of an
Unit of Endocrinology, Diabetes Mellitus and Metabolism, ARETAIEION University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Unit of Endocrinology, Diabetes Mellitus and Metabolism, ARETAIEION University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Unit of Endocrinology, Diabetes Mellitus and Metabolism, ARETAIEION University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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). Placental CRH stimulates in a non-circadian, pulsatile mode, maternal pituitary corticotropin (ACTH), which further stimulates the maternal adrenal cortex to release cortisol ( 1 ). Similarly, it stimulates the secretion of fetal pituitary ACTH. This bi
National Hospital for Neurology and Neurosurgery, London, UK
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National Hospital for Neurology and Neurosurgery, London, UK
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Careful assessment of fluid and electrolyte balance Ideally, endocrine evaluation with blood samples for random serum cortisol, TSH, free T 4 , prolactin, IGF1, LH, FSH, testosterone (men), oestradiol (women) for later analysis Bedside assessment of
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Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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compared. Patients’ cognitive parameters were compared to normal values of the general population. Hormone assays Blood draw for the laboratory routine and hormones cortisol and aldosterone was performed in a standardized procedure in the morning
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(anatomical and/or functional), management modalities and outcomes. Basic biochemical evaluation included 08:00h serum cortisol, plasma adrenocorticotropic hormone (ACTH), serum cortisol after overnight dexamethsone suppression test (ODST), plasma free
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St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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altered cortisol synthesis with reduced cortisol levels in affected persons ( 1 , 2 ). Additionally, aldosterone synthesis is impaired in about 75% of cases resulting in salt-wasting CAH. The CAH form with salt-wasting is characterized as classic CAH (SW
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). The majority of these tumors secrete hormones, especially androgens and cortisol, and the most common clinical presentation is a virilizing syndrome – isolated or associated with Cushing syndrome ( 17 ). The diagnosis of ACT is suggested by clinical
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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University Rehabilitation Institute, Ljubljana, Slovenia
FAMNIT, University of Primorska, Koper, Slovenia
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Clinical Institute of Radiology, University Medical Centre Ljubljana, Ljubljana, Slovenia
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Clinical Institute of Radiology, University Medical Centre Ljubljana, Ljubljana, Slovenia
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selectivity index (SI), determined as the ratio of concentrations of cortisol from an adrenal vein and the infra-adrenal inferior vena cava (IVC), was at least 5 on both sides ( 28 , 29 ). Lateralization index (LI) was calculated as the gradient of the higher