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of total and free testosterone, fasting glucose and fasting insulin. Statistical analysis Meta-analysis was performed using metafor package, version 1.9–5 in R 3.1.2 software. Freeman–Tukey double arcsine transformation that provides the
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INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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Département d'Endocrinologie et de Gynécologie Pédiatrique, Hôpital Arnaud de Villeneuve, Université de Montpellier, Montpellier, France
INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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of testosterone and gonadotropins in plasma. Moreover, quantification of plasma 17-hydroxyprogesterone, and possibly of other androgens (e.g. delta-4 androstenedione (A4) and dehydroepiandrosterone sulfate (DHEA-S)), and abdominopelvic ultrasonography
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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more rapid feminisation with greater testosterone suppression and enhanced breast development ( 2 ), however, others raise concerns regarding breast cancer and cardiovascular disease risk with the use of progestins ( 3 ). Due to a lack of evidence
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, insulin, total testosterone (TT), Δ4-androstenedione (Δ4A), dehydroepiandrosterone sulfate (DHEA-S) and sex hormone-binding globulin (SHBG) were assessed in the early follicular phase of the menstrual cycle. Homeostatic model assessment-insulin resistance
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. Several observational studies have reported that estradiol (E2) and testosterone are protective factors against CVD events in women and men, respectively ( 19 , 20 ). The incidence of CVD was lower in premenopausal women than in men. However, in
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hormone (LH), follicle-stimulating hormone (FSH), testosterone (T) and dihydrotestosterone (DHT), androstenedione (A) and unstimulated and/or stimulated 17-hydroxy progesterone 17(OH) P levels (where indicated). Congenital adrenal hyperplasia was diagnosed
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Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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. References 1 Laaksonen DE Niskanen L Punnonen K Nyyssonen K Tuomainen TP Valkonen VP Salonen R Salonen JT . Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men . Diabetes Care
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), estradiol (318 girls: 920; 658 boys: 1405) and testosterone (319 girls: 930; 658 boys: 1405). Genotyping Peripheral blood (EDTA-preserved) was used for isolation of genomic DNA using the QuickGene-810 Nucleic Acid Isolation System (Fujifilm, Life
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tumors or M-ACT), when androgen excess was combined with autonomous cortisol secretion, confirmed by a dexamethasone suppression test ( 17 ). Plasma concentration of dehydroepiandrosterone sulfate (DHEA-S), androstenedione, testosterone and 17
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Clinical Chemistry System (Siemens Medical Solutions). Insulin was measured using a solid-phase enzyme-amplified sensitivity immunoassay (INS-EASIA; Biosource Technologies, Nivelles, Belgium). Total testosterone was measured by ELISA (testosterone enzyme