Lukas Ochsner Ridder
Lukas Ochsner Ridder
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Agnethe Berglund
Agnethe Berglund
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Kirstine Stochholm
Kirstine Stochholm
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
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Simon Chang
Simon Chang
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Claus H Gravholt
Claus H Gravholt
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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(follicle-stimulating hormone, luteinizing hormone) and 65–85% of KS patients having decreased testosterone levels ( 6 ). KS patients may have signs of hypogonadism regardless of testosterone levels within the normal range. Even though current guidelines
Dorte Glintborg
Dorte Glintborg
Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
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Hanne Mumm
Hanne Mumm
Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
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Jens Juul Holst
Jens Juul Holst
Department of Biomedical Sciences and NNF Centre for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
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Marianne Andersen
Marianne Andersen
Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
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free testosterone ( 14 ). OCP may increase body weight ( 15 ) and insulin resistance ( 14 , 16 ), which could be associated with decreased GLP-1 levels. In contrast, animal studies suggested that estradiol and progesterone treatment could increase the
Sebastian Franik
Sebastian Franik
Department of Obstetrics and Gynaecology, Radboudumc, Nijmegen, The Netherlands
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Kathrin Fleischer
Kathrin Fleischer
Department of Obstetrics and Gynaecology, Radboudumc, Nijmegen, The Netherlands
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Barbara Kortmann
Barbara Kortmann
Department of Pediatric Urology, Radboudumc, Nijmegen, The Netherlands
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Nike M Stikkelbroeck
Nike M Stikkelbroeck
Department of Internal Medicine, Radboudumc, Nijmegen, The Netherlands
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Kathleen D’Hauwers
Kathleen D’Hauwers
Department of Urology, Radboudumc, Nijmegen, The Netherlands
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Claire Bouvattier
Claire Bouvattier
Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, France
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Jolanta Slowikowska-Hilczer
Jolanta Slowikowska-Hilczer
Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Poland
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Solange Grunenwald
Solange Grunenwald
Department of Endocrinology and Metabolic Disease, Centre Hospitalier Universitaire de Toulouse, France
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Tim van de Grift
Tim van de Grift
Departments of Plastic Surgery and Medical Psychology, Amsterdam UMC location VUmc, Amsterdam, The Netherlands
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Audrey Cartault
Audrey Cartault
Department of Pediatrics, Hospital Des Enfants, Toulouse, France
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Annette Richter-Unruh
Annette Richter-Unruh
Kinderendokrinologie und Diabetologie, Universitätsklinikum Ruhr-Universität Bochum, Kinderklinik, Bochum, Germany
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Nicole Reisch
Nicole Reisch
Department of Endocrinology, Medizinische Klinik and Poliklinik IV, University Hospital Munich, Munich, Germany
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Ute Thyen
Ute Thyen
Klinik fur Kinder- und Jugendmedizin, Universitat zu Lubeck, Ratzeburger Allee, Lubeck, Germany
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Joanna IntHout
Joanna IntHout
Department for Health Evidence, Radboudumc, Nijmegen, The Netherlands
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Hedi L Claahsen-van der Grinten
Hedi L Claahsen-van der Grinten
Department of Pediatric Endocrinology, Amalia Childrens Hospital, Radboudumc, Nijmegen, The Netherlands
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the dsd-LIFE group
the dsd-LIFE group
the dsd-LIFE group
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, psychological well-being, psychosexual outcome, testosterone treatment, fertility, experiences with care, and sexuality. To ensure confidentiality, the participants were asked to fill out the PRO with a secure password, either in the clinic or at home. Data were
Jan Roar Mellembakken
Jan Roar Mellembakken
Division of Gynecology and Obstetrics, Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway
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Azita Mahmoudan
Azita Mahmoudan
Division of Gynecology and Obstetrics, Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway
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Lars Mørkrid
Lars Mørkrid
Department of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway
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Inger Sundström-Poromaa
Inger Sundström-Poromaa
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
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Laure Morin-Papunen
Laure Morin-Papunen
Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland
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Juha S Tapanainen
Juha S Tapanainen
Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland
Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Uusimaa, Finland
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Department of Obstetrics and Gynecology, Helsinki University Hospital and University of Helsinki, Helsinki, Uusimaa, Finland
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Terhi T Piltonen
Terhi T Piltonen
Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Centre Oulu and PEDEGO Research Unit, Oulu, Finland
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Angelica Lindén Hirschberg
Angelica Lindén Hirschberg
Department of Women’s and Children’s Health, Karolinska Institutet and Department of Gynecology and Reproductive Medicine, Stockholm, Sweden
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Elisabet Stener-Victorin
Elisabet Stener-Victorin
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Eszter Vanky
Eszter Vanky
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, UK
Department of Gynecology and Obstetrics, St. Olav’s Hospital, Trondheim, Norway
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Department of Gynecology and Obstetrics, St. Olav’s Hospital, Trondheim, Norway
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Pernille Ravn
Pernille Ravn
Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
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Richard Christian Jensen
Richard Christian Jensen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Marianne Skovsager Andersen
Marianne Skovsager Andersen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Dorte Glintborg
Dorte Glintborg
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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PCOS is undetermined. Testosterone levels could be an important modifier of vascular health in PCOS, but whether testosterone has a protective or unfavorable impact on the risk of CVD in PCOS is debated ( 7 , 15 ). We are not aware of studies
Mohamed Hssaini
Mohamed Hssaini
Department of Pediatric Endocrinology, University Hospital Center Hassan II, Fez, Morocco
Laboratory of Biotechnology, Environment, Food, and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco
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Laboratory of Biotechnology, Environment, Food, and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco
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Sana Abourazzak
Sana Abourazzak
Department of Pediatric Endocrinology, University Hospital Center Hassan II, Fez, Morocco
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Ihsane El Otmani
Ihsane El Otmani
Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Morocco
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Mohamed Ahakoud
Mohamed Ahakoud
Medical Genetics Laboratory, University Hospital Center Hassan II, Fez, Morocco
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Amina Ameli
Amina Ameli
Department of Pediatric Endocrinology, University Hospital Center Hassan II, Fez, Morocco
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Laila Bouguenouch
Laila Bouguenouch
Medical Genetics Laboratory, University Hospital Center Hassan II, Fez, Morocco
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Hicham Bekkari
Hicham Bekkari
Laboratory of Biotechnology, Environment, Food, and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco
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recorded. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and cortisol levels were assessed by chemiluminescence immunoassay (Cobas® e411 by Roche). Testosterone and 17-hydroxypregnenolone were measured by
Alan D Rogol
Alan D Rogol
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
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puberty ↑AMH Small testes (onset mid-adolescence) Adolescent usually normal testosterone, but ↑ FSH, LH Speech and behavioral problems Adult primary hypogonadism 47,XYY Tall stature FSH ↑ but not to levels in XXY normal or
Jan-Bernd Stukenborg
Jan-Bernd Stukenborg
NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
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Kirsi Jahnukainen
Kirsi Jahnukainen
NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Marsida Hutka
Marsida Hutka
MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Rod T Mitchell
Rod T Mitchell
MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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in many other non-human primates, including the rhesus monkey and marmoset ( 7 , 8 ). In humans and non-human primates after the rise in gonadotrophins and testosterone during early infancy, there follows a period of relative HPG quiescence during
Bledar Daka
Bledar Daka
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Thord Rosen
Thord Rosen
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Per Anders Jansson
Per Anders Jansson
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Lennart Råstam
Lennart Råstam
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Charlotte A Larsson
Charlotte A Larsson
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Ulf Lindblad
Ulf Lindblad
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
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Introduction Sex hormone-binding globulin (SHBG) is a circulating plasma globulin binding sex hormones, both oestradiol and testosterone and is produced primarily by the liver. In two recent studies, SHBG could predict type 2 diabetes (T2D) in
Karim Gariani
Karim Gariani
Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Testosterone - Testicles - Primary hypogonadism (congenital abnormalities, acquired diseases) - Secondary hypogonadism (pituitary disease (LH) or hypothalamic disease (GnRH)) Prolactin - Pituitary gland - Micro or macroprolactinoma - Stalk effect
Sarah Byberg
Sarah Byberg
Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark
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Jesper Futtrup
Jesper Futtrup
Panum Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Mikkel Andreassen
Mikkel Andreassen
Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark
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Jesper Krogh
Jesper Krogh
Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark
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-density lipoprotein (LDL), triglycerides (TRG), fasting plasma glucose, HOMA-IR, fasting serum insulin, glycated hemoglobin (HbA1c), plasma testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), high-sensitivity C-reactive protein (hsCRP) and
