Search Results

You are looking at 1 - 1 of 1 items for :

  • Abstract: Arteries x
  • Abstract: Atherosclerosis x
  • Abstract: Ghrelin x
  • Abstract: Veins x
  • Abstract: Heart x
  • Abstract: cardiac* x
Clear All Modify Search
Xiaoyi Qi Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
Medical College, Shantou University, Shantou, China

Search for other papers by Xiaoyi Qi in
Google Scholar
PubMed
Close
,
Liangxian Qiu Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China

Search for other papers by Liangxian Qiu in
Google Scholar
PubMed
Close
,
Shijia Wang Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China

Search for other papers by Shijia Wang in
Google Scholar
PubMed
Close
,
Xiongbiao Chen Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China

Search for other papers by Xiongbiao Chen in
Google Scholar
PubMed
Close
,
Qianwen Huang Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China

Search for other papers by Qianwen Huang in
Google Scholar
PubMed
Close
,
Yixuan Zhao Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
Medical College, Shantou University, Shantou, China

Search for other papers by Yixuan Zhao in
Google Scholar
PubMed
Close
,
Kunfu Ouyang Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China

Search for other papers by Kunfu Ouyang in
Google Scholar
PubMed
Close
, and
Yanjun Chen Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China

Search for other papers by Yanjun Chen in
Google Scholar
PubMed
Close

Background

Heart failure (HF) is a complex and multifactorial syndrome caused by impaired heart function. The high morbidity and mortality of HF cause a heavy burden of illness worldwide. Non-thyroidal illness syndrome (NTIS) refers to aberrant serum thyroid parameters in patients without past thyroid disease. Observational studies have indicated that NTIS is associated with a higher risk of all-cause mortality in HF. This meta-analysis aimed to investigate the association between NTIS and HF prognosis.

Methods

Medline, Embase, Web of Science, and the Cochrane database were searched for any studies reporting an association between NTIS and HF prognosis from inception to 1 July 2022. A meta-analysis was then performed. The quality of studies was assessed using the Newcastle–Ottawa Scale. The heterogeneity of the results was assessed with I 2 and Cochran's Q statistics. Sensitivity analysis and publication bias analysis were also conducted.

Results

A total of 626 studies were retrieved, and 18 studies were finally included in the meta-analysis. The results showed that NTIS in HF patients was significantly associated with an increased risk of all-cause mortality and major cardiovascular events (MACE), but not with in-hospital mortality. The stability of the data was validated by the sensitivity analysis. There was no indication of a publication bias in the pooled results for all-cause mortality and MACE.

Conclusions

This meta-analysis showed that NTIS was associated with a worse outcome in HF patients. However, the association between NTIS and in-hospital mortality of HF patients requires further investigation.

Open access