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Department of Anatomy, Shanxi Medical University, Taiyuan, China
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Y Brown J Martinez OI Melton DA . Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation . Nature 2004 429 41 – 46 . ( https://doi.org/10.1038/nature02520 ) 6 Xu X D'Hoker J Stange G Bonne S
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://doi.org/10.4049/jimmunol.0903636 ) 19 Hsieh CC Lin CL He JT Chiang M Wang Y Tsai YC Hung CH & Chang PJ . Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice . Stem Cell Research
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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cholangiocytes ( 1 , 24 ). Particularly, ECC cells are mainly derived from cells located in the peribiliary glands (PBGs), which contain stem/progenitor cells for biliary tree regeneration and can differentiate toward islet cells in T2D ( 25 ). Long
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inhibits osteogenic differentiation of bone marrow mesenchymal stem cells via regulating miR-493-5p/ZEB2 signalling . Journal of Biochemistry 2020 167 613 – 621 . ( https://doi.org/10.1093/jb/mvaa011 ) 54 Wang X Ma H Sun J Zheng T Zhao P Li H
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and adhesion of diabetic endothelial cells, as well as a relative decrease in VEGF secretion by mesenchymal stem cells and wound fibroblasts, have been observed in diabetic skin ( 9 , 10 ). Finally, adipose stem cells from diabetic mice showed a
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evaluating the risk of diabetic complications in patients with T2D. Stromal cell-derived factor 1 (SDF-1) belonging to the CXC chemokine family is widely expressed in various tissues and regulates several aspects of stem cell function ( 11 ). Sustainable
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diabetic nephropathy . Clinica Chimica Acta 2021 523 131 – 143 . ( https://doi.org/10.1016/j.cca.2021.09.003 ) 36 Zheng S Zhang K Zhang Y He J Ouyang Y Lang R Ao C Jiang Y Xiao H Li Y , Human umbilical cord mesenchymal stem cells
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Faculty of Medicine, University of Latvia, Riga, Latvia
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insulin sensitivity and beta-cell function and subsequently glycaemic control. GLP-1 receptor agonists and dual hormone therapies have exhibited promising outcomes in those with T2D and obesity. Tirzepatide, a dual GLP-1 and GIP receptor agonist, has