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Valeria Hirschler
Valeria Hirschler
University of Buenos Aires, Buenos Aires, Argentina
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Claudia Molinari
Claudia Molinari
University of Buenos Aires, Buenos Aires, Argentina
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Silvia Lapertosa
Silvia Lapertosa
UNNE, Corrientes, Argentina
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Gustavo Maccallini
Gustavo Maccallini
Hidalgo Laboratories, Buenos Aires, Argentina
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Claudio D Gonzalez
Claudio D Gonzalez
CEMIC, Buenos Aires, Argentina
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the 1980s, Ruderman et al. studied a group of adults who had normal weight but who were metabolically unhealthy as they presented lower insulin sensitivity, higher triglycerides, and cardiovascular disease ( 5 ). Normal-weight adults with central OB
Mirjana Doknic
Mirjana Doknic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Marko Stojanovic
Marko Stojanovic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Ivan Soldatovic
Ivan Soldatovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Medical Statistics and Informatics, Belgrade, Serbia
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Institute of Medical Statistics and Informatics, Belgrade, Serbia
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Tatjana Milenkovic
Tatjana Milenkovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Vera Zdravkovic
Vera Zdravkovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
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University Children’s Clinic, Belgrade, Serbia
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Maja Jesic
Maja Jesic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
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University Children’s Clinic, Belgrade, Serbia
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Sladjana Todorovic
Sladjana Todorovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Katarina Mitrovic
Katarina Mitrovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Rade Vukovic
Rade Vukovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
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Dragana Miljic
Dragana Miljic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Dragan Savic
Dragan Savic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Mihajlo Milicevic
Mihajlo Milicevic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Aleksandar Stanimirovic
Aleksandar Stanimirovic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Vojislav Bogosavljevic
Vojislav Bogosavljevic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Sandra Pekic
Sandra Pekic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Emilija Manojlovic-Gacic
Emilija Manojlovic-Gacic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Aleksandar Djukic
Aleksandar Djukic
Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
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Danica Grujicic
Danica Grujicic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
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Milan Petakov
Milan Petakov
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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at first evaluation after transfer from pediatrics to adult endocrine care; (ii) longitudinal analysis of BC and BMD alterations after 3 years of rhGH replacement in TP. Metabolic profile was assessed by analyzing fasting glycemia, fasting insulin
Mei Li
Mei Li
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Yanfei Chen
Yanfei Chen
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Binrong Liao
Binrong Liao
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Jing Tang
Jing Tang
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Jingzi Zhong
Jingzi Zhong
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Dan Lan
Dan Lan
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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-2000i, Shenzhen, China), with intra- and inter-assay CVs of LH, FSH, and E2 less than 10%. Insulin-like growth factor-1 (IGF-1) was tested by chemiluminescence (BIOBASE, MAGLUMI 4000 plus, Shandong, China). The serum MKRN3 and kisspeptin levels were
Valentina Guarnotta
Valentina Guarnotta
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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Silvia Lucchese
Silvia Lucchese
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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Mariagrazia Irene Mineo
Mariagrazia Irene Mineo
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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Donatella Mangione
Donatella Mangione
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Ostetricia e Ginecologia, Università di Palermo, Palermo, Italy
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Renato Venezia
Renato Venezia
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Ostetricia e Ginecologia, Università di Palermo, Palermo, Italy
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Piero Luigi Almasio
Piero Luigi Almasio
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Gastroenterologia ed Epatologia, Università di Palermo, Palermo, Italy
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Carla Giordano
Carla Giordano
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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) ( 1 , 2 ). Insulin resistance with total, visceral, and hepatic adiposity is thought to be a major driver of such early maturation ( 3 , 4 ). Non-classical congenital adrenal hyperplasia or heterozygous carriers of 21-hydroxylase deficiency can
Anastasia Ibba
Anastasia Ibba
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Francesca Corrias
Francesca Corrias
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Chiara Guzzetti
Chiara Guzzetti
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Letizia Casula
Letizia Casula
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Mariacarolina Salerno
Mariacarolina Salerno
Dipartimento di Pediatria, Università Federico II, Napoli, Italy
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Natascia di Iorgi
Natascia di Iorgi
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Gianluca Tornese
Gianluca Tornese
SSD Endocrinologia Pediatrica, Clinica Pediatrica, IRCCS Materno-infantile Burlo Garofolo, Trieste, Italy
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Giuseppa Patti
Giuseppa Patti
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Giorgio Radetti
Giorgio Radetti
Dipartimento di Pediatria, Ospedale Generale Regionale, Bolzano, Italy
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Mohamad Maghnie
Mohamad Maghnie
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Marco Cappa
Marco Cappa
UOC di Endocrinologia, Dipartimento Universitario Ospedaliero, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy
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Sandro Loche
Sandro Loche
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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synthesis in the liver is stimulated by GH. IGF1 circulates primarily bound to the acid-labile subunit (ALS) and the insulin growth factor binding protein-3 (IGFBP3) ( 4 , 5 , 15 ). IGF1 and IGFBP3 serum levels show little circadian variation, so that a
Volha V Zhukouskaya
Volha V Zhukouskaya
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
Division of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
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Division of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
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Anya Rothenbuhler
Anya Rothenbuhler
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
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APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
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Annamaria Colao
Annamaria Colao
Division of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
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Carolina Di Somma
Carolina Di Somma
Division of Endocrinology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
IRCCS SDN, Naples, Italy
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IRCCS SDN, Naples, Italy
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Peter Kamenický
Peter Kamenický
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
APHP, Department of Endocrinology and Reproductive Diseases, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France
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APHP, Department of Endocrinology and Reproductive Diseases, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France
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Séverine Trabado
Séverine Trabado
Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France
APHP, Department of Molecular Genetics, Pharmacogenetics and Hormonology, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
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APHP, Department of Molecular Genetics, Pharmacogenetics and Hormonology, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
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Dominique Prié
Dominique Prié
Université Paris V, Faculté de Médecine, Paris, France
Hôpital Necker EnfantsMalades APHP, INSERM U1151, Paris, France
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Hôpital Necker EnfantsMalades APHP, INSERM U1151, Paris, France
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Christelle Audrain
Christelle Audrain
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
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Anna Barosi
Anna Barosi
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
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Christèle Kyheng
Christèle Kyheng
APHP, Department of Adolescent Medicine, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
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Anne-Sophie Lambert
Anne-Sophie Lambert
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
APHP, Department of Adolescent Medicine, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
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APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
APHP, Department of Adolescent Medicine, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
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Agnès Linglart
Agnès Linglart
APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, FilièreOSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France
APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France
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APHP, Department of Endocrinology and Diabetology for Children, Bicêtre Paris Saclay Hospital, Le Kremlin-Bicêtre, France
Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France
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tolerance, insulin sensitivity and insulin secretion in non-diabetic subjects . European Journal of Clinical Nutrition 2006 734 – 739 . ( https://doi.org/10.1038/sj.ejcn.1602375 ) 5 Haglin L Lindblad A Bygren LO. Hypophosphatemia in the
Heike Hoyer-Kuhn
Heike Hoyer-Kuhn
Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Angela Huebner
Angela Huebner
Department of Paediatrics, University Children’s Hospital Dresden, Dresden, Germany
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Anette Richter-Unruh
Anette Richter-Unruh
University Children’s Hospital Bochum, Bochum, Nordrhein-Westfalen, Germany
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Markus Bettendorf
Markus Bettendorf
University Children’s Hospital Heidelberg, Heidelberg, Germany
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Tilman Rohrer
Tilman Rohrer
University Children’s Hospital Homburg, Homburg, Germany
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Klaus Kapelari
Klaus Kapelari
University Children’s Hospital Innsbruck, Innsbruck, Austria
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Stefan Riedl
Stefan Riedl
Department of Pediatric, Medical University of Vienna, Vienna, Austria
St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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Klaus Mohnike
Klaus Mohnike
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
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Helmuth-Günther Dörr
Helmuth-Günther Dörr
University Children’s Hospital Erlangen, Erlangen, Germany
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Friedrich-Wilhelm Roehl
Friedrich-Wilhelm Roehl
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
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Katharina Fink
Katharina Fink
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany
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Reinhard W Holl
Reinhard W Holl
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany
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Joachim Woelfle
Joachim Woelfle
University Children’s Hospital Erlangen, Erlangen, Germany
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. Different studies have described alterations of the cortisol clearence, half-life of free cortisol, and insulin resistance leading to a reduction of the treatment efficacy due to an increased androgen secretion in pubertal children ( 24 , 25 , 26 ). The
Thomas Reinehr
Thomas Reinehr
Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Children’s Hospital, University of Witten/Herdecke, Datteln, Germany
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Martin Carlsson
Martin Carlsson
Endocrine Care, Pfizer Inc, New York, New York, USA
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Dionisios Chrysis
Dionisios Chrysis
Division of Pediatric Endocrinology, University of Patras, Patras, Greece
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Cecilia Camacho-Hübner
Cecilia Camacho-Hübner
Endocrine Care, Pfizer Inc, New York, New York, USA
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( 14 ). It is well known that GH and insulin-like growth factor (IGF-I) have also an impact on bone age ( 4 , 26 , 27 ). Therefore, deficiencies in GH and IGF-I lead to growth impairment and bone age delay, while overproduction or administration of GH
Min Yang
Min Yang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Xiangling Deng
Xiangling Deng
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Shunan Wang
Shunan Wang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Bo Zhou
Bo Zhou
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Wenquan Niu
Wenquan Niu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China
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Zhixin Zhang
Zhixin Zhang
International Medical Services, China-Japan Friendship Hospital, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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β-cell function, insulin resistance, glycemia, and type 2 diabetes in finnish men . Journal of Clinical Endocrinology and Metabolism 2017 102 443 – 450 . ( https://doi.org/10.1210/jc.2016-2933 ). 9 Yuan Y Zhou B Wang S Ma J Dong F
