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Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi, Donatella Caruso, Guido Cavaletti, and Manuela Simoni

Introduction Finasteride is an inhibitor of 5 alpha-reductase (5α-R) type 1 and 2 enzymes, encoded by the SRD5A1 and SRD5A2 gene, respectively, with higher affinity for 5α-R type 2 in the human ( 1 , 2 ). This enzyme converts testosterone

Open access

Britt J van Keulen, Conor V Dolan, Bibian van der Voorn, Ruth Andrew, Brian R Walker, Hilleke Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, and Martijn J J Finken

. ( ) 21 Yokoi H Tsuruo Y Miyamoto T Ishimura K . Steroid 5 alpha-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats. Histochemistry

Open access

I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, and K Svechnikov

. Endocrinology 2003 144 575 – 580 . ( doi:10.1210/en.2002-220721 ) 11 Mahendroo M Wilson JD Richardson JA Auchus RJ. Steroid 5alpha-reductase 1 promotes 5α-androstane-3α,17β-diol synthesis in immature mouse testes by two pathways

Open access

Lianghui You, Yan Wang, Yao Gao, Xingyun Wang, Xianwei Cui, Yanyan Zhang, Lingxia Pang, Chenbo Ji, Xirong Guo, and Xia Chi

affected by miR-23b-5p overexpression, thus participating in sustaining thermogenesis. qPCR results showed expression levels of these genes decreased after miR-23b-5p overexpression including AMP-activated protein kinase alpha 1 catalytic subunit ( Ampka1

Open access

Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

. Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase . Journal of Steroid Biochemistry and Molecular Biology 2005 93 269

Open access

A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, and Timothy J Cole

alpha-reductase yielding 11beta-hydroxy-5alpha-androstanedione . Journal of Steroid Biochemistry and Molecular Biology 2013 138 132 – 142 . ( doi:10.1016/j.jsbmb.2013.04.010 ) 10.1016/j.jsbmb.2013.04.010

Open access

Yao Chen and Shu-ying Fang

complicated and ambiguous pathogenesis. Many risk factors have been identified, such as obesity, genetics and early childhood growth patterns ( 4 , 5 ). Data from many studies suggest that genetics is very important in the development of PCOS. A Dutch twin

Open access

Zofia Kolesinska, James Acierno Jr, S Faisal Ahmed, Cheng Xu, Karina Kapczuk, Anna Skorczyk-Werner, Hanna Mikos, Aleksandra Rojek, Andreas Massouras, Maciej R Krawczynski, Nelly Pitteloud, and Marek Niedziela

 LHCGR Leydig cell hypoplasia AR 2p16.3 152790  POR P450 oxidoreductase deficiency AR 7q11.23 124015  SRD5A2 5α-reductase deficiency AR 2p23.1 607306  STAR Lipoid congenital adrenal hyperplasia AR 8p11

Open access

Helle Keinicke, Gao Sun, Caroline M Junker Mentzel, Merete Fredholm, Linu Mary John, Birgitte Andersen, Kirsten Raun, and Marina Kjaergaard

biosynthesis. Cholesterol 7-alpha-monooxygenase ( Cyp7a1 ), mediating the rate-limiting step in BA synthesis, was upregulated, together with sterol 12-alpha-hydroxylase ( Cyp8b1 ) and the cholesterol transporters Sterolin-1 ( Abcg5 ) and sterolin-2 ( Abcg8

Open access

Letícia Ribeiro Oliveira, Carlos Alberto Longui, Guilherme Guaragna-Filho, José Luiz Costa, Rafael Lanaro, David Antônio Silva, Maria Izabel Chiamolera, Maricilda Palandi de Mello, André Moreno Morcillo, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior

MB Steinmetz L Damiani D Maciel-Guerra AT et al . Diagnosis of 5alpha-reductase type 2 deficiency: contribution of anti-Müllerian hormone evaluation . Journal of Pediatric Endocrinology and Metabolism 2005 18 1383 – 1389 . ( https