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Taís S Assmann, Mariana Recamonde-Mendoza, Bianca M De Souza and Daisy Crispim

with genetic and environmental risk factors ( 8 ). In this context, several microRNAs (miRNAs) are released in the circulation and might be used as biomarkers to evaluate health status and disease progression ( 2 ). miRNAs are a class of small

Open access

Susanna Cirera, Sophia G Moesgaard, Nora E Zois, Nathja Ravn, Jens P Goetze, Signe E Cremer, Tom Teerlink, Páll S Leifsson, Jesper L Honge, J Michael Hasenkam and Lisbeth H Olsen

metalloproteinases (MMPs), transforming growth factor β (TGFβ) isoforms, NOS, and natriuretic peptides (7, 8, 9, 10) . Moreover, microRNAs have emerged as new players in many developmental and pathological processes, i.e. cardiac development and heart hypertrophy

Open access

Bingbing Wang, Mayra Cruz Ithier, Nataliya Parobchak, Stacy M Yadava, Jay Schulkin and Todd Rosen

of genomic loci associated with VDR stimulated by 1,25(OH)2D ( P  < 0.05). Number of genomic loci Chromosomes Non-coding RNA genes 1112 1–22, X, Y  MicroRNAs 542 1–22, X, Y  Others 570 1–22, X, Y

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Devis Pascut, Sofia Tamini, Silvia Bresolin, Pablo Giraudi, Giuseppe Basso, Alessandro Minocci, Claudio Tiribelli, Graziano Grugni and Alessandro Sartorio

Desgagné V Bouchard L Guérin R. microRNAs in lipoprotein and lipid metabolism: from biological function to clinical application . Clinical Chemistry and Laboratory Medicine 2017 55 667 – 686 . ( ) 15 Shi C

Open access

Anna-Pauliina Iivonen, Johanna Känsäkoski, Kirsi Vaaralahti and Taneli Raivio

, present, and future . Endocrinology and Metabolism 2015 30 456 – 466 . ( ) 10.3803/EnM.2015.30.4.456 4 Ha M Kim VN . Regulation of microRNA biogenesis . Nature Reviews: Molecular Cell Biology 2014 15

Open access

T P McVeigh, R J Mulligan, U M McVeigh, P W Owens, N Miller, M Bell, F Sebag, C Guerin, D S Quill, J B Weidhaas, M J Kerin and A J Lowery

( 14 ). However, it is possible that this association may be explained by overlapping moderate- or low-penetrance breast-thyroid cancer genetic susceptibility loci ( 15 ). MicroRNAs (miRNAs) are crucial elements in the regulation of gene expression

Open access

E R Polina, F M Oliveira, R C Sbruzzi, D Crispim, L H Canani and K G Santos

volume containing 10 ng of the isolated RNA using a commercial kit according to the manufacturer’s protocol (TaqMan® MicroRNA RT; Thermo Fisher Scientific). Reactions were incubated in a standard thermal cycler (PTC-150; MJ Research, Waltham, USA) for 30

Open access

Elena Valassi, Natalia García-Giralt, Jorge Malouf, Iris Crespo, Jaume Llauger, Adolfo Díez-Pérez and Susan M Webb

-335-3p, miR-7-1-3p, miR-22-3p, miR-660-5p and miR-10b-5p were selected based on a preliminary screening, which was performed in six patients and six controls using miRCURY LNATM Universal RT microRNA PCR Serum/Plasma Focus panel (Exiqon) (Supplementary

Open access

Magnolia Ariza-Nieto, Joshua B Alley, Sanjay Samy, Laura Fitzgerald, Francoise Vermeylen, Michael L Shuler and José O Alemán

critical changes in the expression and function of genes. The presence of MIR148A has been associated with DNA hypomethylation caused by sequence complementarity between MIR148A and DNMT1 ( 15 , 16 , 17 ). MicroRNAs in general have large amounts of

Open access

Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

diagnostic and prognostic molecular markers of PTC. In the last 8 years, studies on PTC have been focused on microRNAs (miRNAs), a class of endogenous, small noncoding RNA molecules that function as negative regulators of the expression of protein