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Rui-yi Tang, Rong Chen, Miao Ma, Shou-qing Lin, Yi-wen Zhang, and Ya-ping Wang

Introduction Idiopathic hypogonadotropic hypogonadism (IHH) is also known as congenital hypogonadotropic hypogonadism. This rare clinically and genetically heterogeneous disorder is characterized by complete or partial pubertal failure, which

Open access

Ja Hye Kim, Yunha Choi, Soojin Hwang, Ji-Hee Yoon, Jieun Lee, Min Jae Kang, Gu-Hwan Kim, Han-Wook Yoo, and Jin-Ho Choi

panel sequencing for molecular diagnosis of Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism . Experimental and Clinical Endocrinology and Diabetes 2019 127 538 – 544 . ( https://doi.org/10.1055/a-0681-6608 ) 7 Amato LGL

Open access

Ja Hye Kim, Yunha Choi, Soojin Hwang, Gu-Hwan Kim, Han-Wook Yoo, and Jin-Ho Choi

-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome . American Journal of Human Genetics 2008 83 511 – 519 . ( https://doi.org/10.1016/j.ajhg.2008.09.005 ) 18834967 10.1016/j.ajhg.2008.09.005 5 Shin SJ Sul Y Kim JH Cho

Open access

M I Stamou, P Varnavas, L Plummer, V Koika, and N A Georgopoulos

Kirel B Saka N , Distribution of gene mutations associated with familial normosmic idiopathic hypogonadotropic hypogonadism . Journal of Clinical Research in Pediatric Endocrinology 2012 4 121 – 126 . ( https://doi.org/10.4274/jcrpe.725 ) 10

Open access

Tristan Avril, Quentin Hennocq, Anne-Sophie Lambert, Juliane Leger, Dominique Simon, Laetitia Martinerie, and Claire Bouvattier

, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism . Journal of Clinical Endocrinology and Metabolism 2002 87 152 – 160 . ( https://doi.org/10.1210/jcem.87.1.8131 ) 7 Sarfati J Bouvattier C Bry

Open access

Fernanda A Correa, Ericka B Trarbach, Cintia Tusset, Ana Claudia Latronico, Luciana R Montenegro, Luciani R Carvalho, Marcela M Franca, Aline P Otto, Everlayny F Costalonga, Vinicius N Brito, Ana Paula Abreu, Mirian Y Nishi, Alexander A L Jorge, Ivo J P Arnhold, Yisrael Sidis, Nelly Pitteloud, and Berenice B Mendonca

idiopathic hypogonadotropic hypogonadism . PNAS 2007 104 17447 – 17452 . ( doi:10.1073/pnas.0707173104 ). 12 Trarbach EB Costa EM Versiani B de Castro M Baptista MT Garmes HM de Mendonca BB Latronico AC . Novel fibroblast growth factor

Open access

Catarina I Gonçalves, José M Aragüés, Margarida Bastos, Luísa Barros, Nuno Vicente, Davide Carvalho, and Manuel C Lemos

– 28 . ( doi:10.1016/j.mce.2011.04.018 ) 6 Bianco SD Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism . Nature Reviews Endocrinology 2009 5 569 – 576 . ( doi:10.1038/nrendo.2009.177 ) 7 Lemos

Open access

Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian A Groth, Kurt Kristensen, Anne Grethe Jurik, Niels H Birkebæk, and Claus H Gravholt

.1210/jcem.85.8.6747 ) 16 Yialamas MA Dwyer AA Hanley E Lee H Pitteloud N Hayes FJ . Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism . Journal of Clinical Endocrinology and

Open access

Bruno Donadille, Muriel Houang, Irène Netchine, Jean-Pierre Siffroi, and Sophie Christin-Maitre

Metabolism 1974 39 370 – 374 . ( https://doi.org/10.1210/jcem-39-2-370 ) 10.1210/jcem-39-2-370 26 Pitteloud N Hayes FJ Dwyer A Boepple PA Lee H Crowley WF. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic

Open access

Shota Dzemaili, Jitske Tiemensma, Richard Quinton, Nelly Pitteloud, Diane Morin, and Andrew A Dwyer

hypogonadotropic hypogonadism and Kallmann’s syndrome): pathophysiological and genetic considerations . Endocrine Reviews 1998 19 521 – 539 . 8 Quinton R Duke VM Robertson A Kirk JM Matfin G de Zoysa PA Azcona C MacColl GS