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consecutive treatment-naïve Chinese outpatients with obesity, including 80 males and 40 females, from Renji Hospital Endocrine Department (Shanghai, China) from September 2019 to December 2020 (ChiCTR2200066123). All the patients underwent clinical
German Center for Diabetes Research (DZD), Neuherberg, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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Department of Internal Medicine IV, University Hospital Tübingen, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
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Division of Endocrinology and Diabetology, Department of Internal Medicine 1, University Hospital Ulm, Ulm, Germany
Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany
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Institute of Health Services Research and Health Economics, Center for Health and Society, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Institute of Health Services Research and Health Economics, German Diabetes Center (DDZ), Leibniz Centre for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
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Department of Psychiatry and Psychotherapy II, University Hospital Ulm, Um, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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) were excluded. Cases with unknown sex (overall less than 0.02% of all inpatient cases: n = 285 in 2015; n = 175 in 2016; n = 1073 in 2017; n = 2790 in 2018; n = 0 in 2019; n = 0 in 2020) were assigned to the female cases since it was the
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mean age was 48.86 ± 17.00 years. The gender distribution was in a generally homogeneous manner, of which 49.47% were males and 50.53% were females. The overall prevalence of DKD in T2D was 20.74% (weighted proportion). The findings suggest that CKD
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were considered to be in the menopause. In total, 1045 patients were excluded for the following reasons: premenopausal female ( n = 239); male age below 50 years ( n = 156); presence of viral liver disease or autoimmune hepatitis ( n = 171
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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.1) 14.4 (10.7; 33.8) 0.006 <0.001 ns <0.001 Female (%) 46.7 46.4 64.0 61.9 ns ns ns ns Age at last visit (years) 18.4 (15.4; 39.1) 70.1 (60.0; 78.1) 21.0 (17.9; 49.5) 21.1 (15.7; 44.1) ns <0.001 ns <0
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Global Health Research Institute, School of Human Development and Health, University of Southampton, Southampton, UK
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associated with the presence of non-alcoholic fatty liver disease (NAFLD) ( 33 ), but it is not known whether the effects of leg and gluteofemoral fat on hepatic steatosis are mediated by adiponectin. A longitudinal study of 2683 lean, postmenopausal females
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. n (%) Age mean ( s.d .) Female n (%) BMI SDSmean (S.D.) BF % mean (S.D.) Hypertension n (%) Whole study population 103 (100) 11.6 (2.5) 42 (40.8) 2.6 (0.5) 35.4 (4.5) 49 (47.5) <10 years 24 (23) 8.5 (1
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Objective
Clusterin is closely correlated with insulin resistance and its associated comorbidities. This study aimed to investigate the correlation between serum clusterin levels and non-alcoholic fatty liver disease (NAFLD) and further explore the mediating role of insulin resistance in this relationship.
Methods
This study enrolled 195 inpatients (41 males and 154 females) aged 18–61 years. Twenty-four patients were followed up for 12 months after bariatric surgery. Serum clusterin levels were measured using a sandwich enzyme-linked immunosorbent assay. Fatty liver disease was diagnosed on the basis of liver ultrasonography. The fatty liver index (FLI) was calculated to quantify the degree of hepatic steatosis. The mediating role of homeostasis model assessment-insulin resistance (HOMA-IR) was assessed using mediation analysis.
Results
Participants with NAFLD had significantly higher serum clusterin levels than those without NAFLD (444.61 (325.76–611.52) mg/L vs 294.10 (255.20–373.55) mg/L, P < 0.01). With increasing tertiles of serum clusterin levels, the prevalence of NAFLD displayed an upward trend (P < 0.01). Multivariate linear regression analysis showed that serum clusterin levels were a positive determinant of FLI (standardized β = 0.271, P < 0.001) after adjusting for multiple metabolic risk factors. Serum clusterin levels significantly decreased after bariatric surgery (298.77 (262.56–358.10) mg/L vs 520.55 (354.94–750.21) mg/L, P < 0.01). In the mediation analysis, HOMA-IR played a mediating role in the correlation between serum clusterin levels and FLI; the estimated percentage of the total effect was 17.3%.
Conclusion
Serum clusterin levels were associated with NAFLD. In addition, insulin resistance partially mediated the relationship between serum clusterin levels and FLI.
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Objective
To explore the relationship between C-peptide secretion and time in range (TIR) in adult patients with type 1 diabetes.
Methods
From December 2018 to December 2020, 76 type 1 diabetes participants were enrolled from the Department of Endocrinology and Metabolism of Peking University People’s Hospital. All participants wore intermittently scanned continuous glucose monitoring (isCGM), and insulin dosage was adjusted according to standardized clinical procedures. Subjects were divided into low C-peptide group (<10 pmol/L) and preserved C-peptide group (10–200 pmol/L) based on fasting serum C-peptide levels. Differences of TIR, metrics related to glucose variability and hypoglycemic events were compared.
Results
A total of 94,846 isCGM values obtained from 39 male and 37 female participants were analyzed. Individuals with preserved C-peptide secretion had shorter diabetes duration (2.0 (0.5, 10.0) vs 10.0 (3.0, 18.3) years, P = 0.002). TIR was higher in the individuals with preserved C-peptide than those with decreased C-peptide (67.1% (54.2, 75.8) vs 45.5% (33.9, 56.1), P < 0.001), and time above range was significantly lower in those with preserved C-peptide (28.0% (15.6, 42.4) vs 49.4% (39.1, 64.2), P < 0.001). Preserved C-peptide was associated with lower glucose variability, as defined by s.d. (3.0 mmol/L (2.6, 3.4) vs 3.8 mmol/L (3.2, 4.3), P < 0.001) and interquartile range (4.3 mmol/L (3.1, 4.8) vs 5.3 mmol/L (4.5, 6.3), P < 0.001). Metrics related to hypoglycemia were not different between the two groups.
Conclusion
Preserved C-peptide secretion was associated with higher TIR and lower glucose variability in Chinese type 1 diabetes adults.
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female reproductive system that results in failure to conceive after 12 months or longer of natural fertilization ( 10 ). According to estimates by the World Health Organization, about one in six couples of reproductive age worldwide may need assisted
