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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Division of Musculoskeletal Section, Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
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School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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two units of alcohol for adult males and one unit for females, with one unit equal to 10 g of pure alcohol ( https://www.mohw.gov.tw/cp-6562-75242-1.html ). The date of the DXA examination was designated as the date of enrollment. During the follow
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, 39 , 40 ) that were conducted in females ( 39 , 40 ) and males ( 26 ) only. The included studies mostly considered the following potential confounders: sex, age, weight, BMI, cohort characteristics, Tanner stage, fat mass index, body fat mass
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measure BMD and define osteoporosis as being ≤2.5 standard deviations ( s.d. ) of the mean BMD in young healthy females ( 1 ). Osteoporosis can cause increased bone fragility and risks of osteoporotic fractures ( 2 ). It was estimated that the annual case
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Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK
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-based changes will facilitate the application of these techniques for studying the developing skeleton in more detail in health and disease. Methods The study cohort A total of 161 healthy male (n = 76) and female (n = 85) children and young people
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acute HP symptoms ( n = 42) Presentation for other diseases/HP comorbidities ( n = 107) P -value Age 61.5 ± 18.9 58.2 ± 21.8 64.9 ± 17.0 0.132 Gender 34/69.4% (female) 15/30.6% (male) 26/61.9% (female) 16/38.1% (male
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany
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Objective
Asprosin is a recently discovered hormone associated with obesity and diabetes mellitus. Little is known about asprosin’s role during pregnancy, but a contribution of asprosin to pregnancy complications resulting from maternal obesity and gestational diabetes mellitus (GDM) is conceivable. We assessed the potential effects of obesity, GDM and other clinical parameters on maternal and fetal umbilical plasma asprosin concentrations and placental asprosin expression.
Design
The Cologne-Placenta Cohort Study comprises 247 female patients, from whom blood and placentas were collected at the University Hospital Cologne.
Methods
We studied the maternal and fetal umbilical plasma and placentas of pregnant women with an elective, primary section. Sandwich ELISA measurements of maternal and fetal umbilical plasma and immunohistochemical stainings of placental tissue were performed to determine the asprosin levels. Also, the relation between asprosin levels and clinical blood parameters was studied.
Results
There was a strong correlation between the maternal and fetal plasma asprosin levels and both increased with GDM in normal-weight and obese women. Asprosin immunoreactivity was measured in cultivated placental cells and placental tissue. BMI and GDM were not but pre-pregnancy exercise and smoking were correlated with maternal and/or fetal asprosin levels. Placental asprosin levels were associated with maternal but not with fetal plasma asprosin levels and with BMI but not with GDM. Placental asprosin was related to maternal insulin levels and increased upon insulin treatment in GDM patients.
Conclusions
Asprosin could potentially act as a biomarker and contribute to the clinical manifestation of pregnancy complications associated with maternal obesity.
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Paris Saclay University, AP-HP, DMU SEA, Endocrinology and Diabetes for Children, Le Kremlin Bicêtre, France
Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, Le Kremlin Bicêtre, France
Filière OSCAR and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, INSERM-U1185, Le Kremlin Bicêtre, France
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APHP-Center for Rare Diseases of Calcium and Phosphate Metabolism, Paris, France
Hôpital Bretonneau, Service de Médecine Bucco-Dentaire, GH Nord Université de Paris, Paris, France
Université de Paris, Inserm U1163, Institute Imagine, Paris, France
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APHP-Center for Rare Diseases of Calcium and Phosphate Metabolism, Paris, France
Hôpital Bretonneau, Service de Médecine Bucco-Dentaire, GH Nord Université de Paris, Paris, France
Université de Paris, URP2496, Paris, France
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Université de Paris Laboratoire ECEVE INSERM, UMR1123, Hôpital Robert Debré, Paris, France
Centre de Reference, Maladies Orales et Dentaires Rares, Hôpital Rothschild, APHP, Paris, France
Filière de Santé Maladies Rares TETECOU, Malformations Rares de la tête, du cou et des dents, Hôpital Necker, Paris, France
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, subcategories, and categories. Themes Subthemes Quotations Expressed feelings Sadness ‘I could no longer do my passion because I used to dance a lot, I could no longer dance’. (female, 61 years old, invalid) ’It affects life
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) Calcium (mmol/L) PTH (pg/mL) MEN1 mutation 1 Wu et al. ( 8 ) 1992 Male 48 4.1 154 – 2 Sato et al. ( 9 ) 2000 Female 51 2.7 – c.734del p.(Pro245Leufs*36) 3 Dionisi et al. ( 10 ) 2002 Male
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significantly lower prevalence compared to females (4.4% vs 5.7%, respectively) in the US survey but significantly higher prevalence (11.1% vs 6.6%, respectively) in the Canadian survey ( Fig. 2 ). Figure 2 The prevalence of serum 25(OH)D < 30 nmol/L in
Fondazione Italiana Ricerca sulle Malattie dell’Osso (FIRMO Onlus), Florence, Italy
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population (mean age, 72.8 ± 15.7 years) and 55.2% were female. Although age and BMI were similar in males and females, a higher proportion of males were previous smokers and a lower proportion were never smokers. Levels of the biologically active form of