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Tiina Vesterinen, Teijo Kuopio, Maarit Ahtiainen, Aija Knuuttila, Harri Mustonen, Kaisa Salmenkivi, Johanna Arola, and Caj Haglund

confirmed by routine immunohistochemical labeling for chromogranin A, synaptophysin and pan-cytokeratin. One hundred and thirty-one patients (78%) were diagnosed with TC and 37 (22%) with AC tumors. Surgery was the first-line treatment for all patients

Open access

Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag, and Henriette Kirchner

Study design and patients To establish a tissue bank for metabolic disorders, liver wedge biopsies were obtained in a standardized fashion from segment III during bariatric surgery of obese subjects at University Hospital Eppendorf (UKE, Hamburg). All

Open access

K Amrein, A Papinutti, E Mathew, G Vila, and D Parekh

Journal of Surgery , 2012Atlanta, USA ( 74 ) Prospective observational studySurgical ICU patients 258 25(OH)D was categorized as severe deficiency in 25(OH)D (≤13 ng/mL), moderate deficiency (14–26 ng/mL) and mild deficiency (27–39 ng

Open access

T Grimmichova, M Haluzik, K Vondra, P Matucha, and M Hill

sensitivity; Smoking or history of smoking. a R , Component loadings expressed as correlation coefficients with predictive component, b P  < 0.05, c P  < 0.01. Next, the group of patients undergoing thyroid surgery was analyzed, comparing

Open access

Katherine Van Loon, Li Zhang, Jennifer Keiser, Cendy Carrasco, Katherine Glass, Maria-Teresa Ramirez, Sarah Bobiak, Eric K Nakakura, Alan P Venook, Manisha H Shah, and Emily K Bergsland

regarding baseline sociodemographic factors, tumor staging, symptoms, and cancer-directed treatments, including all treatments delivered at the NCCN and outside institutions (e.g., surgeries, radiation therapy, systemic therapy), were included in the chart

Open access

Susanna Cirera, Sophia G Moesgaard, Nora E Zois, Nathja Ravn, Jens P Goetze, Signe E Cremer, Tom Teerlink, Páll S Leifsson, Jesper L Honge, J Michael Hasenkam, and Lisbeth H Olsen

disease (MMVD), leading to adaptive remodeling, enlargement, and subsequent dysfunction of the left ventricle (1) . Severe MR may need surgery, and if left untreated, it can cause heart failure or serious arrhythmia. In the USA, about 18 000 patients

Open access

Lisette van Alewijk, Kirsten Davidse, Karlijn Pellikaan, Judith van Eck, Anita C S Hokken-Koelega, Theo C J Sas, Sabine Hannema, Aart J van der Lely, and Laura C G de Graaff

undergo surgery, I know how to change my hydrocortisone dosage 2 8 4 6 10 3 1 1 3 4 1 2 3 0 3 17 P =0.23 P =0.29 I know what can happen if I do not change the hydrocortisone dosage in these situations 4 5 4

Open access

Shruti Khare, Anurag R Lila, Hiren Patt, Chaitanya Yerawar, Manjunath Goroshi, Tushar Bandgar, and Nalini S Shah

treatment was defined as resistance. In resistant patients, maximum dose of cabergoline used was 7 mg/week and if still unresponsive, second line therapies were offered. Second line management includes trans-sphenoidal surgery (TSS) by a single experienced

Open access

Xiaoya Zheng, Shanshan Yu, Jian Long, Qiang Wei, Liping Liu, Chun Liu, and Wei Ren

Objective: Both primary thyroid lymphoma (PTL) and diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) are two rare malignant tumours with different therapies and prognoses. This study compared their clinical features.

Methods: From a retrospective review of the pathologic database at our institute between January 2015 and August 2020, 52 PTL patients and 40 DSVPTC patients were included. Demographic, clinical, laboratory and ultrasound data were extracted from electronic medical records. Statistical analyses were performed using GraphPad Prism 5.0.

Results: Both PTL and DSVPTC were more likely to occur in women (83.7% and 67.5%), but DSVPTC patients were younger (median age: 36 vs 64.5), had fewer compressive symptoms, and more frequently had neck lymph node metastasis than PTL patients. The prevalence of Hashimoto’s thyroiditis (HT) and hypothyroidism was significantly higher in PTL patients than in DSVPTC patients (31% vs 17.5%). Hyperthyroidism could only be found in DSVPTC patients, which accounted for 7.5%. Heterogeneous echogenicity and irregular edges were frequently observed in both PTL and DSVPTC. However, compared with PTL, DSVPTC exhibited smaller lesion sizes, higher frequencies of diffuse sonographic patterns and calcification, and lower frequencies of hypoechoic features and internal blood flow signal. The overall survival rate with PTL was 77.23%, which was lower than that with DSVPTC (90.91%), but this difference was not significant (p=0.096).

Conclusion: Clinical characteristics such as age, compression symptoms, and sonographic features such as a large mass with heterogeneous echogenicity, hypoechoic, irregular edges, and calcification are helpful for impression diagnosis of PTL and DSVPTC before surgery.

Open access

Qian Wang, Jiacheng Wang, Yunhui Xin, Ziyang He, Xiang Zhou, Xing Liu, Teng Zhao, Lihan He, Hong Shen, Mulan Jin, and Bojun Wei

Background: Parathyroid carcinoma (PC), often misdiagnosed as parathyroid adenoma (PA), is prone to local relapse due to the initial surgery being restricted to parathyroid lesions instead of en bloc resection of parathyroid lesions with negative incision margins. However, it is very challenging to distinguish PC from PA preoperatively; hence, this study investigated an effective biomarker for increasing accuracy in PC diagnosis.

Method: First, differentially expressed the circular RNAs between three PC tissues and three PA tissues were screened by high-throughput circular RNA sequencing, and the expression of hsa_circ_0005729 was verified by qRT-PCR in 14 patients with PC and 40 patients with PA. Second, the receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to analyze the diagnostic efficiency of hsa_circ_0005729 in PC by combining with laboratory data. Third, RNF138 mRNA, the corresponding linear transcript of hsa_circ_0005729 was measured, and the relationship between hsa_circ_0005729 and RNF138 mRNA was analyzed in patients with PA and patients with PC.

Results: Hsa_circ_0005729 expression was significantly higher in patients with PC than in patients with PA. Serum calcium (p = 0.045), alkaline phosphatase (ALP) (p = 0.048), and creatinine levels (p = 0.036) were significantly higher in patients with PC than in patients with PA. The AUC increased to 0.86 when hsa_circ_0005729 combined with serum calcium, creatinine, and ALP. In addition, hsa_circ_0005729 was positively correlated with RNF138 mRNA in patients with PA but not in patients with PC.

Conclusion: The novel circular RNA hsa_circ_0005729 was found to have a higher expression in patients with PC, and indicating its usefulness for distinguishing PC from PA.