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Open access

Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila, and Heikki A Koistinen

between total OC and insulin resistance which appeared to be mediated by BMI (45) . Based on these findings, the proposed link between insulin sensitivity and bone metabolism remains uncertain in humans and further studies are required. The strengths of

Open access

M Boering, P R van Dijk, S J J Logtenberg, K H Groenier, B H R Wolffenbuttel, R O B Gans, N Kleefstra, and H J G Bilo

CIPII and the subsequent increased hepatic insulinization may cause a more pronounced suppression of SHBG production. Apart from portal insulin concentrations, other factors such as glycemic control, insulin dose, insulin resistance, and the presence of

Open access

Lisa Arnetz, Neda Rajamand Ekberg, Kerstin Brismar, and Michael Alvarsson

Introduction Along with progressive β-cell failure and insulin resistance, patients with type 2 diabetes (T2D) display disturbed regulation of cortisol and insulin-like growth factor 1 (IGF1) secretion (1) . Especially regarding the hypothalamus

Open access

Alice S Ryan, John C McLenithan, and Gretchen M Zietowski

, women with prior GDM are at a heightened risk for subsequent CVD complications. Aging is also associated with increased obesity, insulin resistance, and CVD risk (11, 12, 13) . Thus, as women age with a history of GDM, they may be faced with a worsening

Open access

Wenqi Yang, Ling Liu, Yuan Wei, Chunlu Fang, Fu Zhou, Jinbao Chen, Qinghua Han, Meifang Huang, Xuan Tan, Qiuyue Liu, Qiang Pan, Lu Zhang, Xiaojuan Lei, and Liangming Li

insulin resistance and show more disorganized liver lipid metabolism compared to their WT littermate controls ( 3 , 4 , 5 ). On the other hand, replenishment of FGF21 can reduce obesity, improve insulin sensitivity and increase glucose clearance ( 5 , 6

Open access

R Solomon-Zemler, L Basel-Vanagaite, D Steier, S Yakar, E Mel, M Phillip, L Bazak, D Bercovich, H Werner, and L de Vries

particular, a rare state of IGF-1 deficiency related to a homozygous partial deletion in the IGFI gene ( IGF1 ) has been associated with severe insulin resistance, which was normalized by IGF-1 therapy ( 38 ). IGF-1 resistance due to the mutation could block

Open access

Bledar Daka, Thord Rosen, Per Anders Jansson, Lennart Råstam, Charlotte A Larsson, and Ulf Lindblad

(17) . Serum insulin was analysed using RIA. Insulin resistance was estimated using the homeostatic model assessment for insulin resistance (HOMA-IR) (18) . Total testosterone was analysed according to UniCel DxI 800 Beckman Access Immunoassay System

Open access

Mohammed S Albreiki, Benita Middleton, and Shelagh M Hampton

.7%), control 2 = 24.5 (6.7%) and control 3 = 49.6 pg/mL (6.8%)) and insulin (control 1 = 100.3 pmol/L (10%), and control 2 = 332.2 pmol/L (9.5%)). Measurement of insulin resistance An index of fasting insulin resistance (HOMA-IR) and postprandial

Open access

Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel, and André P van Beek

. Furthermore, to gain insight in the mechanisms provoking hypoglycaemia, we performed gut hormone analyses and assessed the beta-cell function and insulin resistance with several indices. Patients and methods Study population Details on the study

Open access

Peter Wolf, Yvonne Winhofer, Martin Krššák, and Michael Krebs

, increased epicardial and pericardial fat is linked with changes in heart function in men suffering from metabolic syndrome ( 28 ), as well as in obese patients suffering from insulin resistance ( 29 ). Of note, MYCL and pericardial fat are two lipid stores