Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Introduction Type 1 diabetes mellitus (T1DM), which is caused by the selective destruction of the insulin-producing β cells located in the pancreatic islets of Langerhans, is one of the most common and debilitating autoimmune diseases ( 1
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one of the most influential regulators of growth hormone (GH) secretion and action, with different mechanisms ( 2 ). Androgens and estrogens exert opposite endocrine-mediated effects on insulin-like growth factor (IGF)-I production and metabolic
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Introduction The burgeoning epidemic of gestational diabetes mellitus (GDM) threatens maternal and infant health. GDM is characterized by glucose intolerance, which causes poorly controlled diabetes during pregnancy. Insulin resistance is an
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information on the pathogenesis of T1DM. We will present genetic, environmental and immunologic factors ( Table 1 ) that eventually destroy β cells of the endocrine pancreas and lead to insulin deficiency. Table 1 Contributing factors in type 1 diabetes
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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that expression of 2% of our genome is regulated by glucocorticoids ( 5 ). Prednisolone is known to induce insulin resistance, increased hepatic glucose production, hyperglycaemia and secondary diabetes. Even lean, healthy individuals can experience
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Introduction Diabetes devices are rapidly advancing in their features and functionalities, offering a range of benefits for individuals with type 1 diabetes who opt to use this technology. Current diabetes technology includes insulin pumps
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Region Jönköping County, Jönköping, Sweden
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Introduction Blood glucose levels are tightly regulated by insulin and glucagon. In type 2 diabetes, the ability of insulin to suppress endogenous glucose production is impaired, and increased fasting and postprandial glucagon levels stimulate
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute of Medical Research, University of Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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8-h overnight fast was taken for measurement of serum lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides) and glucose metabolism (serum insulin and glucose). Insulin sensitivity was calculated using the homeostatic
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). Melatonin is considered the classical phase marker for assessing the timing of the mammalian biological clock. The SCN drives the daily rhythms in hormone concentrations such as insulin, glucagon, corticosterone ( 4 , 5 , 6 ) and enzymes involved in lipid
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dysfunction and characteristic image of the ovaries in the ultrasound ( 2 ). A lot of data indicated that insulin resistance is a key factor in the development of metabolic disturbances in PCOS, for example, obesity, type 2 diabetes (T2D), cardiovascular