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M S Elston, V B Crawford, M Swarbrick, M S Dray, M Head, and J V Conaglen

may result in an increase in 11-deoxycortisol, which may cross-react with cortisol in cortisol immunoassays ( 12 ). Mineralocorticoid blockade was performed using spironolactone, as eplerenone was not available. Spironolactone may worsen androgen

Open access

Karim Gariani and François R Jornayvaz

release of androstenedione and testosterone ( 78 ). Indeed, insulin acts as a co-gonadotropin to increase luteinizing hormone (LH), therefore, stimulating androgens production. A concomitant decrease in sex hormone binding globulin (SHBG) mediated both by

Open access

E Kohva, P J Miettinen, S Taskinen, M Hero, A Tarkkanen, and T Raivio

inquiry. 46,XY DSD  E34.5 Androgen insensitivity syndrome  Q53.2 Undescended testicle, bilateral  Q54.2 Hypospadias, penoscrotal  Q54.3 Hypospadias, perineal  Q55.00 Absence and aplasia of testis  Q55

Open access

Luca Boeri, Paolo Capogrosso, Walter Cazzaniga, Edoardo Pozzi, Luigi Candela, Federico Belladelli, Davide Oreggia, Eugenio Ventimiglia, Nicolò Schifano, Giuseppe Fallara, Marina Pontillo, Costantino Abbate, Emanuele Montanari, Francesco Montorsi, and Andrea Salonia

the patient may have altered SHBG concentrations ( 4 , 5 ), the importance of calculated fT (cFT) and SHBG over tT alone in assessing symptoms of androgen deficiency in men with sexual dysfunctions has been recently outlined ( 3 , 6 ). Similarly

Open access

Stefan Riedl, Friedrich-Wilhelm Röhl, Walter Bonfig, Jürgen Brämswig, Annette Richter-Unruh, Susanne Fricke-Otto, Markus Bettendorf, Felix Riepe, Gernot Kriegshäuser, Eckhard Schönau, Gertrud Even, Berthold Hauffa, Helmuth-Günther Dörr, Reinhard W Holl, Klaus Mohnike, and the AQUAPE CAH Study Group

cortisol and aldosterone. Consequently, the precursors of these hormones accumulate and are shunted in the androgen pathway causing androgen excess. A complete loss of 21-OH function results in salt-wasting (SW) phenotypes, while a minimal residual 21-OH

Open access

Emanuelle Nunes-Souza, Mônica Evelise Silveira, Monalisa Castilho Mendes, Seigo Nagashima, Caroline Busatta Vaz de Paula, Guilherme Guilherme Vieira Cavalcante da Silva, Giovanna Silva Barbosa, Julia Belgrowicz Martins, Lúcia de Noronha, Luana Lenzi, José Renato Sales Barbosa, Rayssa Danilow Fachin Donin, Juliana Ferreira de Moura, Gislaine Custódio, Cleber Machado-Souza, Enzo Lalli, and Bonald Cavalcante de Figueiredo

, bone and muscle loss. The adrenal ZR is the main source of low potency androgens in females, and this loss may have consequences in aging for skin, muscle and bone metabolism. Similarly, changes in the ZR were reported previously as a reduced mass in

Open access

Britt J van Keulen, Conor V Dolan, Bibian van der Voorn, Ruth Andrew, Brian R Walker, Hilleke Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, and Martijn J J Finken

, unfortunately our study lacked a more detailed assessment of body composition. It is unclear whether the sex differences in cortisol metabolism that we observed are androgen- or estrogen mediated. A study in adult men showed that testosterone reduced the CRH

Open access

Nicolás Crisosto, Bárbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren, and Teresa Sir-Petermann

next stage of puberty. Higher androstenedione may come from the testis or the adrenal gland. A possible explanation is that there is an increased secretion of androgens from the adrenal gland as has been suggested in PCOS women ( 30 , 31 ), and then as

Open access

Raymond J Rodgers, Jodie C Avery, Vivienne M Moore, Michael J Davies, Ricardo Azziz, Elisabet Stener-Victorin, Lisa J Moran, Sarah A Robertson, Nigel K Stepto, Robert J Norman, and Helena J Teede

awareness of the condition is limited, while PCOS research is inadequate and poorly funded ( 4 ). PCOS is a reproductive and metabolic condition with psychological consequences ( 5 ). Women with PCOS suffer symptoms of excess androgen (hirsutism, acne

Open access

M Jensterle, A Podbregar, K Goricar, N Gregoric, and A Janez

Montori VM & Task Force, Endocrine Society . Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline . Journal of Clinical Endocrinology and Metabolism 2010 95 2536 – 2559 . ( https