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indexes after correction for differences in age and delivery BMI between the two groups were estimated using covariance analysis. Statistical significance was set as P < 0.05. Statistical analyses were conducted using SPSS 21.0 (IBM). A power
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Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester, UK
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Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester, UK
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pilot study is the small sample size, which has insufficient power to detect a small effect size. Our findings must therefore be interpreted with caution, and a larger, adequately powered study is required. Another limitation is that there are many
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
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considering the extremely low probability that any of the ESRD patients had endogenous Cushing's syndrome. This is similar to previous studies in patients with diabetes mellitus (37) . It is important to reiterate that this study was powered to compare the
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microcarcinoma and in the normal surrounding thyroid tissue. (A and B) H&E staining (in B microcarcinoma at higher power view). (C and D) NOTCH1 staining. NOTCH1 positivity is restricted to microcarcinoma (in the center; in D at higher power view), while normal
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of the two groups are equivalent, this study needed a sample size at least 19 cases in each group to gain power of 90% at 95% confidence interval and testing margin of 1%. Statistical analysis Statistical analyses were performed by SPSS
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PTCs thus have different distributions of branching vessels and microvascularization. Previous studies found that it was difficult to differentiate the microvasculature within lesions using color Doppler flow imaging (CDFI) and power Doppler imaging
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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, 24 ). Our dataset does not have the power to examine risk factors for peroperative hemodynamic instability but while keeping this limitation in mind, it suggests that medical pretreatment with PBZ titrated to orthostatic hypotension reduces
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SDHB . High-power (A) and low-power (B) H&E staining images of metastatic pheochromocytoma deposits in the iliac and peri-vesicular lymph nodes at presentation. CT (C) and PET-CT (D) images showing metastatic deposits of pheochromocytoma in the pelvic
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Department of General Surgery, St. Elisabeth’s Hospital, Graz, Austria
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Hypercalcemia may occur, but less frequent compared with ‘older’ active analogs Very expensive What endocrinology can learn from intensive care and vice versa Sample size and power of a study So far, many single vitamin D intervention
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weeks prior to evaluation. Power calculation The primary endpoint of the study was change in adrenal activity (evaluated by 60 min area under the curve (AUC) for ACTH-stimulated cortisol levels) during treatment with escitalopram/placebo. The